psmd14
Share
  • Official Full Name
  • proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
  • Background
  • This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes;the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap;complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on;the long arm of chromosome 2.
  • Synonyms
  • PSMD14; proteasome (prosome, macropain) 26S subunit, non-ATPase, 14; 26S proteasome non-ATPase regulatory subunit 14; pad1; POH1; Rpn11; 26S proteasome regulatory subunit rpn11; 26S proteasome-associated PAD1 homolog 1
Cat.#:PSMD14-2030HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PSMD14, GST-tagged
+Inquiry
Cat.#:PSMD14-6978HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PAD1, GST-tagged
+Inquiry
Cat.#:PSMD14-824CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus PSMD14 Protein, His-tagged
+Inquiry
Cat.#:PSMD14-3670RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PSMD14 Protein, His-tagged
+Inquiry
Cat.#:PSMD14-2914CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PSMD14
+Inquiry
Cat.#:PSMD14-5426ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PSMD14
+Inquiry
Cat.#:PSMD14-2751HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PSMD14 293 Cell Lysate
+Inquiry

Involved Pathway

PSMD14 involved in several pathways and played different roles in them. We selected most pathways PSMD14 participated on our site, such as APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMD14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
APC/C-mediated degradation of cell cycle proteins
CDK2; AURKB; NEK2; PSMD10; PSMD9; PSME3; PSMD14; PSMA8; UBE2C; PSMD5
APC/C:Cdc20 mediated degradation of Securin
PSMA8; PSME3; PSMD9; PSMD5; ANAPC10; PSMD14; PSMD10; UBE2C
APC/C:Cdc20 mediated degradation of mitotic proteins
UBE2C; PSME3; PSMD9; PSMD5; PSMD10; NEK2; PSMA8; ANAPC10; PSMD14
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
PSME3; ANAPC10; PSMD5; PSMD9; PSMD14; UBE2C; PSMA8; AURKB; PSMD10
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
ANAPC10; PSME3; PSMD10; PSMD5; NEK2; PSMD9; UBE2C; PSMD14; PSMA8
ARMS-mediated activation
LAMTOR2; FGF18B; SLC14A2; NETO2; DUSP5; HBEGF; PEA15; PSME3; DAB2IPB; SPRED3
AUF1 (hnRNP D0) binds and destabilizes mRNA
PSMD14; PSMA8; EIF4G1; PSMD5; PSMD9; PSMD10; PSME3; HNRNPD
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
PSME3; ANAPC10; PSMA8; NEK2; PSMD5; UBE2C; PSMD9; PSMD10; PSMD14

Protein Function

PSMD14 has several biochemical functions, for example, endopeptidase activator activity, metal ion binding, metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMD14 itself. We selected most functions PSMD14 had, and list some proteins which have the same functions with PSMD14. You can find most of the proteins on our site.
Function
Related Protein
Function endopeptidase activator activity
Related Protein PSME2; PSMD14; PSME3; PSME1; SFRP2; ADRM1
Function metal ion binding
Related Protein ARSJ; ZNF207B; TRIM12A; PPM1K; SIVA1; ZC3H12A; FTR14; ZIC2B; DCST1; RHEB
Function metallopeptidase activity
Related Protein ADAM8; ADAM1B; ADAM10B; ADAM20; ADAM28; CHMP1A; CNDP2; ADAMTSL3; BMP1A; ANPEP
Function proteasome binding
Related Protein USP14; UCHL5; DNAJB2; ID1; USP13; BAG6; PSMD14; PSMG1; PSMF1; ADRM1
Function protein binding
Related Protein PDGFRB; BARD1; TRPM8; SLAMF1; PTPRE; PPP2CA; ABCD1; EPN1; HMGCR; TCEA1

Interacting Protein

PSMD14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMD14 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMD14.
PSMD7; PSMD6; UCHL5; MEOX2; PSMD11; PSMD12