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GNB2L1

Official Full Name

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
Overview

Seems to bind protein kinase C acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and ITGB1, serves as a platform for SRC activation or inactivation. May play an important role in the developing brain and neuronal differentiation.
Synonyms

GNB2L1; guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1; guanine nucleotide-binding protein subunit beta-2-like 1; Gnb2 rs1; H12.3; RACK1; Receptor for Activated C Kinase 1; lung cancer oncogene 7; proliferation-inducing gene 21; human lung cancer oncogene 7 protein; receptor of activated protein kinase C 1; cell proliferation-inducing gene 21 protein; guanine nucleotide-binding protein subunit beta-like protein 12.3; protein homologous to chicken B complex protein, guanine nucleotide binding; HLC-7; PIG21; Gnb2-rs1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
MBP
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GNB2L1-1375H	Recombinant Human Guanine Nucleotide-Binding Protein Subunit Beta-2-Like 1, His-tagged	E.coli	His		Inquiry
Human	GNB2L1-30327TH	Recombinant Human GNB2L1, His-tagged	E.coli	His		Inquiry
Human	GNB2L1-465H	Recombinant Human GNB2L1 protein, His&MBP-tagged	E.coli	His/MBP	Met1-Arg317	Inquiry
Human	GNB2L1-5862HCL	Recombinant Human GNB2L1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	GNB2L1-2655H	Recombinant Human GNB2L1 protein, His-tagged	E.coli	His	131-317 aa	$319 / 25ug
Mouse	GNB2L1-7028M	Recombinant Mouse GNB2L1 Protein	Mammalian Cell	His		Inquiry
Mouse	GNB2L1-3767M	Recombinant Mouse GNB2L1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	GNB2L1-3767M-B	Recombinant Mouse GNB2L1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	GNB2L1-9012Z	Recombinant Zebrafish GNB2L1	Mammalian Cell	His		Inquiry
Chicken	GNB2L1-1197C	Recombinant Chicken GNB2L1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

GNB2L1 involved in several pathways and played different roles in them. We selected most pathways GNB2L1 participated on our site, such as Androgen receptor signaling pathway, BDNF signaling pathway, CXCR4-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNB2L1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Androgen receptor signaling pathway	PARK7;RNF6;CREBBP;DAXX;RANBP9;JUN;POU2F1B;ZMIZ1;STUB1
BDNF signaling pathway	CDK5;LINGO1;EIF4E;KCNN2;SIRPA;IGF2BP1;MAP3K2;YBX1;FRS3
CXCR4-mediated signaling events	MAPKAP1;CFL1;BLK;PAG1;JAK2;ADRBK1;CSK;GNA13;ARR3
Death Receptor Signalling	FAM105B;SHRPRBCK1R;RNF31;TAB1;RBCK1;GNB2L1;USP2;OTUD7B;USP4
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	NAA10;HIF3A;GNB2L1;HIF1AN;COPS5
IGF1 pathway	GNB2L1;GRB10
IL-3 Signaling Pathway	BIRC5A;CISH;GNB2L1;GATA2A;GATA1A;PILRB;GSK3AB;GATA1;KCNIP3
Interferon type I	PIAS3;GNB2L1

GNB2L1 has several biochemical functions, for example, SH2 domain binding, cysteine-type endopeptidase activator activity involved in apoptotic process, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNB2L1 itself. We selected most functions GNB2L1 had, and list some proteins which have the same functions with GNB2L1. You can find most of the proteins on our site.

Function	Related Protein
SH2 domain binding	NUP62;TRPV4;LCK;GNB2L1;ARHGAP5;SQSTM1;LILRB1;SHCBP1;PTK2
cysteine-type endopeptidase activator activity involved in apoptotic process	BCL2L13;BAD;MAPK9;CTSC;RPS27L;CTSH;CARD8;CASP1;PYCARD
enzyme binding	STUB1;CBX3;MSH2;SCN5A;SCNM1;HIST1H2AI;HIST1H2AD;RPS19BP1;MLL5
ion channel inhibitor activity	GNB2L1;RSC1A1;STOML1;ENSA;PDZD3;KCNV1;KCNMB2
poly(A) RNA binding	IFI203;HIST1H1C;AKAP8;DYNC1H1;NOC4L;ANKHD1;DARS;PUM2;FYTTD1
protein binding	CALML3;PRAME;ITGB3BP;ADH1A;PSEN1;SCG2;TPD52L2;TBCEL;NFE2L1
protein complex scaffold	SEPT2;DISC1;MPP7;CAPN3;CHCHD3;HOMER1;SLC9A1;CAV2;MAGI1
protein homodimerization activity	NOD1;ZBTB16;NR0B1;NR0B2;THRA;SYNDIG1;GJC3;C6orf108;PVRL2
protein kinase C binding	HDAC9;SDC4;LDB3;MARCKS;PRKCSH;GRK5;UGT1A7;TOP2A;GLRX3
protein phosphatase binding	KAT2A;MAP2K7;TP53;DLG3;FLT4;ANAPC7;EGFR;IRS2;MET
protein tyrosine kinase inhibitor activity	FGFR1OP;GNB2L1;IBTK
receptor binding	LHB;JAK2;ICOSLG;FZD1;PVRL1;UCN2;ACOX1;ANGPTL1;CLCF1
receptor tyrosine kinase binding	PLCG1;LRP4;ANGPT4;PTPN2;PCNA;ELMO2;SHC4;NRG3;ANGPT2
signaling adaptor activity	GNB2L1;HOMER1;SH2B2;SH2B1;SH2B3;AFAP1L2;MPP7;LDLRAP1

GNB2L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNB2L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNB2L1.

DYNLL1; VHL; PPID; bzlf1_ebvb9

Research Area

Phospholipases, Small GTPases, and Other Molecules in the Akt Pathway

Sun, Y; Tao, Y; et al. The schizophrenia/bipolar disorder candidate gene GNB1L is regulated in human temporal cortex by a cis-acting element located within the 3'-region. NEUROSCIENCE BULLETIN 31:43-52(2015).

Guiry, A; Flynn, D; et al. Testes and brain gene expression in precocious male and adult maturing Atlantic salmon (Salmo salar). BMC GENOMICS 11:-(2010).