rad1
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  • Official Full Name
  • RAD1 homolog
  • Background
  • This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described.
  • Synonyms
  • RAD1; RAD1 homolog (S. pombe); RAD1 (S. pombe) homolog; cell cycle checkpoint protein RAD1; cell cycle checkpoint protein Hrad1; checkpoint control protein HRAD1; DNA repair exonuclease REC1; exonuclease homolog RAD1; HRAD1; Rad1 like DNA damage checkpoin
Cat.#:RAD1-2151HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAD1, GST-tagged
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Cat.#:RAD1-2756HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAD1 Homolog (S. pombe), His-tagged
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Cat.#:RAD1-31287THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAD1, His-tagged
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Cat.#:RAD1-13861MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RAD1 Protein
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Cat.#:RAD1-3772RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RAD1 Protein, His-tagged
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Cat.#:RAD1-11141ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RAD1
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Cat.#:RAD1-2564HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human RAD1 293 Cell Lysate
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Involved Pathway

RAD1 involved in several pathways and played different roles in them. We selected most pathways RAD1 participated on our site, such as Activation of ATR in response to replication stress, Cell Cycle, Cell Cycle Checkpoints, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of ATR in response to replication stress
CDK2; RAD9B; RAD9A; RAD1; DBF4; MCM10; MCM8; HUS1; CHEK1; RAD9
Cell Cycle
HDAC1; MIS18BP1; SMC1A; MAD1L1; RAD9A; CDC16; YWHAQ; RAD9B; STAG1; CUL1B
Cell Cycle Checkpoints
MCM8; CDK2; UBE2V2; HIST4H4; BRE; FAM175A; BABAM1; CLSPN; UIMC1; HTATIP
DNA Double-Strand Break Repair
GEN1; KDM4A; RAD1; RTEL1; EYA4; POLD3; PPP4R2; SMARCA5; TIPIN; PPP4CB
DNA Repair
UBE2V2; BARD1; DNA2; TP53BP1; PPP4R2; USP10; THRSP; TDP2; MAD2L2; GEN1
DNA damage response
RAD9A; HUS1B; GADD45A; GADD45G; RAD17; CHEK2; CDK5; TLK2; RAD1; DDB2
G2/M Checkpoints
BABAM1; BRCC3; RAD17; BARD1; RAD9B; FAM175A; HUS1; RNF168; RAD9; BRE
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
RAD51AP1; WRN; PPP4R2; PPP4R2B; UIMC1; TIPIN; HUS1; RTEL1; BABAM1; PPP4CA

Protein Function

RAD1 has several biochemical functions, for example, 3-5 exonuclease activity, damaged DNA binding, exodeoxyribonuclease III activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAD1 itself. We selected most functions RAD1 had, and list some proteins which have the same functions with RAD1. You can find most of the proteins on our site.
Function
Related Protein
Function 3-5 exonuclease activity
Related Protein RAD9B; REV3L; RAD1; APEX1; ERI1; EXOSC10; WRN; MRE11A; TREX1; POLE
Function damaged DNA binding
Related Protein RAD52; UNG; XPC; TP63; OGG1; REV1; H2AFX; RAD23AB; APTX; RPA3
Function exodeoxyribonuclease III activity
Related Protein TREX1; RAD9; RAD9A; RAD1; TREX2
Function protein binding
Related Protein MAP1B; RHBDD1; DNAJB2; UQCC1; C17orf81; ANXA4; SCNM1; DMC1; AHCYL1; FRMPD2

Interacting Protein

RAD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAD1.
HUS1; RAD9A; PARK2; MAP1LC3B

RAD1 Related Articles

Bozdarov, J; Sherry, JP; et al. The rad1 gene in Rainbow Trout (Oncorhynchus mykiss) is highly conserved and may express proteins from non-canonical spliced isoforms. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 157:16-23(2013).
Saberi, A; Nakahara, M; et al. The 9-1-1 DNA clamp is required for immunoglobulin gene conversion. MOLECULAR AND CELLULAR BIOLOGY 28:6113-6122(2008).