|Official Full Name||recombination activating gene 2|
|Background||his gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.|
|Synonyms||RAG2; recombination activating gene 2; V(D)J recombination-activating protein 2; RAG-2|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
RAG2 involved in several pathways and played different roles in them. We selected most pathways RAG2 participated on our site, such as FoxO signaling pathway, Primary i, nodeficiency, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|FoxO signaling pathway||GABARAPL2; SMAD4; PRKAG1; GADD45AA; PLK1; PIK3R3A; BNIP3; FOXO6; SGK1; FBXO32|
|Primary i||IL7R; AICDA; CD3E; Cd79a, Cd79b; UNG; IGLL1; BTK; ICOS; TAP2; CD8B1|
|nodeficiency||ICOS; TAP1; CD3D; IL2RG; CD8B1; IKBKG; RFXAP; AICDA; CD3E; BTK|
RAG2 has several biochemical functions, for example, DNA binding, chromatin binding, methylated histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAG2 itself. We selected most functions RAG2 had, and list some proteins which have the same functions with RAG2. You can find most of the proteins on our site.
|DNA binding||ZNF155; TFDP1A; UBTFL1; DERL3; ZNF764; FOXI3B; RORA; CREBZF; ZFAND5B; NR2C1|
|chromatin binding||PATZ1; POLD1; GATA2A; FOXN4; HMGB1A; KLHDC3; GATA2B; PBX2; MEIS1; EWSR1A|
|methylated histone binding||CAPNS2; CBX8; RBBP5; MTF2; ING5; KDM4A; PHF1; UHRF1; CBX7; ZMYND11|
|phosphatidylinositol binding||TUB; PLD1A; SNX32; HS1BP3; RPS6KC1; SNX25; SNX33; PASK; SNX8; SNX19A|
|phosphatidylinositol-3,4,5-trisphosphate binding||KIF16B; JPH2; AKT1; ZFYVE1; INPPL1; D6WSU116E; MAPKAP1; RAG2; FAM21C; OGT|
|phosphatidylinositol-3,4-bisphosphate binding||ARAP3; GAB2; AKT1; MAPKAP1; SESTD1; KIF16B; ZFYVE1; NCF1; RS1; TTPA|
|phosphatidylinositol-3,5-bisphosphate binding||MAPKAP1; COMMD1; D6WSU116E; SNX3; RS1; CLVS2; KIF16B; FAM21C; CLVS1; WDR45B|
|phosphatidylinositol-4,5-bisphosphate binding||MAPKAP1; RAG2; COMMD1; KCNJ2; SYTL2; FAM123B; D6WSU116E; STXBP6L; SESTD1; TULP1|
|ubiquitin protein ligase activity||HERC5; STUB1; TRIM32; RNF144AB; RNF146; TRAIP; RNF111; MSL2B; HERC3; TRIM72|
|zinc ion binding||GATA2; ZCWPW2; PARP1; COP1; RNF34B; DEF8; MATR3L; ESRRA; CBL; KDM7AB|
RAG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAG2.