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RASSF1

Official Full Name

Ras association (RalGDS/AF-6) domain family member 1
Overview

This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Synonyms

RASSF1; Ras association (RalGDS/AF-6) domain family member 1; ras association domain-containing protein 1; 123F2; NORE2A; RDA32; REH3P21; Ras association domain containing protein 1; Ras association domain family 1; Ras association domain family protein 1; RASF1_HUMAN; RASSF 1a; RASSF1A; RASSF1A isoform; Tumor suppressor protein RDA32; WUGSC:H_LUCA12.5; OTTHUMP00000195503; OTTHUMP00000195504; OTTHUMP00000195505; OTTHUMP00000195507; cardiac-specific ras association domain family 1 protein; pancreas-specific ras associat;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	RASSF1-740H	Recombinant Human RASSF1	Mammalian Cell	His	Inquiry
Human	RASSF1-376H	Recombinant Human Ras association (RalGDS/AF-6) domain family member 1, His-tagged	E.coli	His	Inquiry
Human	RASSF1-2499HCL	Recombinant Human RASSF1 293 Cell Lysate	HEK293	N/A	Inquiry
Human	RASSF1-3967H-B	Recombinant Human RASSF1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Human	RASSF1-3967H	Recombinant Human RASSF1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Zebrafish	RASSF1-1274Z	Recombinant Zebrafish RASSF1	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
RASSF1 Related Research Area
RASSF1 Related Signal Pathway

RASSF1 involved in several pathways and played different roles in them. We selected most pathways RASSF1 participated on our site, such as Bladder cancer, Hippo signaling pathway, MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with RASSF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Bladder cancer	DAPK2;SRC;MMP2;DAPK3;BRAF;UPK3A;E2F2;KRAS;TRP53
Hippo signaling pathway	GLI2;FRMD6;LIMD1;BMPR2;WNT2;ID2;YWHAE;NKD1;WNT6
MicroRNAs in cancer	HRAS;MAPK1;ZEB1;BMPR2;VEGFA;DNMT3B;TPM1;APC2;GLS
Non-small cell lung cancer	KRAS;ARAF;SOS1;MAPK3;PRKCA;PDPK1;PIK3R3;RAF1;RXRG
Pathways in cancer	PLD1;BIRC8;ROCK1;PTGER4;MLH1;FGF9;LAMA2;NFKB1;FADD
Ras signaling pathway	FGF14;KRAS;GNG7;GNGT2;SHOC2;FGF19;PRKACA;PLA2G3;RASSF5
p53 pathway	TTC5;RASSF1;CSNK1G3;PPP1R13L;CSE1L;SMYD2;E4F1;TRIM28;FBXO11

RASSF1 has several biochemical functions, for example, identical protein binding, protein N-terminus binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RASSF1 itself. We selected most functions RASSF1 had, and list some proteins which have the same functions with RASSF1. You can find most of the proteins on our site.

Function	Related Protein
identical protein binding	PDCD6;SERPINA1E;TPD52L1;HAPLN2;GOT1L1;UBE4A;GRB2;UGP2;PSMD4
protein N-terminus binding	TSC1;SMARCE1;MAP2K1;STX5;KCNIP1;THAP7;SLC6A3;NCOR2;CSNK2A2
protein binding	RAG1;APC2;DMPK;FAM32A;CDK7;PSKH1;NGB;VARS2;MPHOSPH6
zinc ion binding	CCS;MMP14B;VDR;RNF130;USP33;PPARD;PGLYRP2;RABGGTA;ZGLP1

RASSF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RASSF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RASSF1.

STK4; STK3; DAXX; SUV39H2

Tumor Suppressors