rgs20
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  • Official Full Name
  • regulator of G-protein signaling 20
  • Background
  • The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • RGS20; regulator of G-protein signaling 20; regulator of G protein signalling 20; RGSZ1; ZGAP1; G(z)GAP; Gz selective GTPase activating protein; HGNC:14600; Regulator of G protein signaling 20; Regulator of Gz selective protein signaling 1; gz-GAP; OTTHUMP00000227381; OTTHUMP00000227383; OTTHUMP00000227397; regulator of G-protein signaling Z1; regulator of G-protein signalling 20; gz-selective GTPase-activating protein; regulator of Gz-selective protein s
Cat.#:RGS20-2279HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RGS20, His-tagged
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Cat.#:RGS20-6405CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RGS20
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Cat.#:RGS20-565ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RGS20
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Cat.#:RGS20-2377HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human RGS20 293 Cell Lysate
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Involved Pathway

RGS20 involved in several pathways and played different roles in them. We selected most pathways RGS20 participated on our site, such as Calcium Regulation in the Cardiac Cell, G alpha (i) signalling events, G alpha (z) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with RGS20 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Calcium Regulation in the Cardiac Cell
CHRM1; CHRM2; PKIG; RGS4; CHRM5; ADRA1D; KCNB1; GJA10; ADRa1A; PKIB
G alpha (i) signalling events
CXCR6; RGS11; POMCB; PNOC; OPN1MW2; OXGR1; SSTR2; NMUR1; ANXA1B; S1PR3
G alpha (z) signalling events
RGS19; ADRA2B; ADRA2C; RGS20; RGS4; ADRA2A; RGS17
GPCR downstream signaling
ARHGEF18; INSL3; OPN1LW1; EDNRAB; ARHGAP4; TAC1; GNA13B; ADORA2A; DCLRE1B; ECT2
Myometrial Relaxation and Contraction Pathways
RGS7; RGS10; ADM; CNN1; CRHR1; RGS18; MYLK2; RGS5; MAFF; CRCP
Signal Transduction
MDKB; NRP2B; PENKB; PDK3; WNT8-2; FAM13B1; CSNK1G2; RDH12; LEO1; TLE2
Signaling by GPCR
GPR65; TAS2R3; GPR77; SCT; OPN4.1; FGD2; ACKR4; VIP2; PROK2; HEBP1

Protein Function

RGS20 has several biochemical functions, for example, GTPase activator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RGS20 itself. We selected most functions RGS20 had, and list some proteins which have the same functions with RGS20. You can find most of the proteins on our site.
Function
Related Protein
Function GTPase activator activity
Related Protein RALBP1; ASAP1; RABGAP1L; RGS9A; ARHGAP23; CDC42EP4A; ARHGAP44; ARHGAP26; RASAL3; RGS13
Function protein binding
Related Protein SLC30A2; PRCP; COX5A; BLNK; C1orf182; ZNF2; RNF220; ADAMTSL4; FANCA; POLG2

Interacting Protein

RGS20 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RGS20 here. Most of them are supplied by our site. Hope this information will be useful for your research of RGS20.
GLRX3; OTX1; CATSPER1; MTNR1A; Hoxa1

RGS20 Related Articles

Walther, S; Strittmatter, F; et al. Expression and Alpha1-adrenoceptor Regulation of Caldesmon in Human Prostate Smooth Muscle. UROLOGY 79:-(2012).
Rivero, G; Gabilondo, AM; et al. Characterization of regulators of G-protein signaling RGS4 and RGS10 proteins in the postmortem human brain. NEUROCHEMISTRY INTERNATIONAL 57:722-729(2010).