rhoa
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  • Official Full Name
  • ras homolog family member A
  • Background
  • Ras is the name given to a family of related proteins which is ubiquitously expressed in all cells, . All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells (cellular signal transduction). Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours.
  • Synonyms
  • RHOA; ras homolog family member A; ARH12, ARHA, ras homolog gene family, member A; transforming protein RhoA; Rho12; RhoA; RHOH12; h12; oncogene RHO H12; rho cDNA clone 12; Aplysia ras-related homolog 12; small GTP binding protein RhoA; ras homolog gene
Cat.#:RHOA-1182HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human RHOA Protein, MYC/DDK-tagged
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Cat.#:RHOA-1627HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ras Homolog Gene Family, Member A, His-tagged
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Cat.#:RHOA-3372HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ras Homolog Gene Family, His-tagged
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Cat.#:RHOA-1145HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ras Homolog Gene Family, Member A
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Cat.#:RHOA-179HTag:His
Source (Host):BacteriaSpecies:Human
Product nameRecombinant Human RHOA, His-tagged
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Cat.#:RHOA-2290HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RHOA, GST-tagged
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Cat.#:RHOA-27379THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RHOA
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Cat.#:RHOA-313HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human RHOA
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Cat.#:RHOA-32HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RHOA protein, His-tagged
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Cat.#:RHOA-33HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RHOA protein, His-tagged
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Cat.#:RHOA-34HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RHOA protein, GST-tagged
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Cat.#:RHOA-3975HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RHOA, His tagged
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Cat.#:RHOA-5035RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RHOA Protein
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Cat.#:RHOA-6269CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RHOA
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Cat.#:RHOA-1146HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ras Homolog Gene Family, Member A, GST-tagged
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Cat.#:RHOA-601HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RHOA cell lysate
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Cat.#:Kit-0768Tag:
Source (Host):Species:
Product nameRhoA Activation ColorimetricAssay Kit (24 assays)
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Cat.#:Kit-0769Tag:
Source (Host):Species:
Product nameRhoA Activation Colorimetric Assay Kit (96 assays)
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Involved Pathway

RHOA involved in several pathways and played different roles in them. We selected most pathways RHOA participated on our site, such as Ras signaling pathway, Rap signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RHOA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
RRAS2; PDGFRB; PRKCB; FGF17; ANGPT4; GNB3; PDGFB; FGFR1; NRAS; PLA2G2F
Rap signaling pathway
FARP2; INS; ITGAL; MAPK3; FLT1; PIK3CB; PDGFA; FGF17; LPAR3; BCAR1
cGMP-PKG signaling pathway
GNAI2; BAD; CREB3L2; ITPR3; NFATC3; CALM3; GNAQ; INS; INS2; ROCK1
cAMP signaling pathway
ATP1A4; CAMK4; CALML5; HTR1B; PDE3A; PPP1CA; FXYD1; PLD1; BDNF; CALM1
Chemokine signaling pathway
CXCL9; WASL; BRAF; CCR9; STAT2; CRK; CXCL16; GM1987; CCL6; ROCK1
Sphingolipid signaling pathway
GNAI2; MAP3K5; BDKRB2; BAX; GNAI1; DEGS1; ABCC1; PRKCA; SMPD2; SPHK2
Phospholipase D signaling pathway
SPHK1; AGPAT3; AGTR1A; PLA2G4D; PLA2G4A; KIT; AVP; CYTH2; GRM6; AGTR1B
Endocytosis
WASB; CAPZA2; MHC1UEA; ARFGAP2; ERBB3B; SMURF1; ARF3; CXCR1; SH3GL1B; RHOA
Vascular smooth muscle contraction
RHOAA; GUCY1B3; PLA2G10; MAP2K2; KCNMB4; MYL12.1; PPP1CAB; PPP1CC; PRKACAB; BRAF
Wnt signaling pathway
FZD8; CAMK2B1; FZD5; CSNK2A2A; CCND1; WNT11R; RAC1A; MYCB; RUVBL1; MAP3K7
TGF-beta signaling pathway
TGIF2; SMAD7B; SMAD5; LFT2; RHOAC; LTBP1; IFNG1-2; ID2A; MAPK1; PITX2
Axon guidance
DPYSL5B; EFNA3; IL17RD; ACTR2; AP2M1; EFNA1A; ST8SIA2; RGMA; SEMA3B; SPNA1
Focal adhesion
ITGA1; ARHGAP5; ACTN4; RAC3A; RAC1A; PIK3R3A; COL1A1; PDGFD; AKT2L; FLNC
Adherens junction
CTNND1; TCF7L1A; YES1; ACP1; WASLB; ACTB2; CSNK2A2A; PTPN1; CDC42; ACTB1
Tight junction
CDC42L; MYLPFB; PARD3; MYL2; CLDNE; GNAIA; TJAP1; LLGL1; GNAI2A; MYHZ2
Platelet activation
BTK; MYL12A; LYN; ARHGEF12; PRKCZ; ITPR3; MYL12B; AKT1; PLA2G4A; ITGB1
T cell receptor signaling pathway
NFATC3; CBLB; MAP2K1; IFNG; CBLC; NFKBIA; MAP3K7; OXSR1A; MAP3K14; PPP3CA
Leukocyte transendothelial migration
JAM2; VCAM1; CLDN8; CLDN4; NCF2; RHOA; ITGA4; MYLPF; Itgam&Itgb2; CXCR4
Neurotrophin signaling pathway
MAPK13; PDPK1; NGF; ARHGDIG; PIK3R5; NTRK1; ATF4; CALM2; AKT2; PSEN1
Regulation of actin cytoskeleton
GNG12; ACTB2; ITGB6; DIAPH3; PIP5K1BA; BRK1; ITGA6B; VCLA; PIP5K1A; PPP1CC
Oxytocin signaling pathway
CAMKK1; PIK3CD; NPR2; PRKAG2; PRKAB1; CALML5; PRKCA; ITPR3; CALML3; PRKAA2
Pancreatic secretion
AMY2A; SCTR; GNAS; CLCA4; RAP1B; PLA2G1B; PNLIPRP2; PLCB3; PLA2G3; ATP1A3
Bacterial invasion of epithelial cells
SHC1; PIK3R3; SHC3; PIK3R2; DNM1; WASF2; ARPC1B; ELMO1; PXN; ACTG1
Pathogenic Escherichia coli infection
OCLN; TUBA1C; PRKCA; ROCK2; ABL1; CD14; ROCK1; TUBB2B; CTTN; TLR5
Pertussis
SERPING1; ITGB2L; C4BP; CFL2; GNAI3; C4A; AMCF-II; RELA; C1QC; CASP1
Tuberculosis
PPP3CC; FCGR2C; ATP6V0D1; TGFB3; IFNA1; AKT2; TRADD; MAPK3; RFXAP; PPP3CB
Pathways in cancer
Adcy4; FAS; PRKCG; GNAI3; IL6; GLI3; GLI2; MET; F2R; MTOR
Viral carcinogenesis
EGR3; MAPKAPK2; PIK3CG; RBL2; GTF2H3; IL6ST; MAPK1; HIST1H2BQ; YWHAH; HIST2H4
Proteoglycans in cancer
FZD9; MSN; GRB2; NUDT16L1; FGF2; MAPK11; FZD5; Ctsl; HSPB2; Fasl
MicroRNAs in cancer
ITGB3; TNR; HDAC1; THBS1; BMPR2; CDC25A; ABCB1; CCND2; TNXB; NRAS
Colorectal cancer
TCF7; PIK3CB; RAC1; GSK3B; PIK3R1; BCL2; TGFB2; MAPK3; PIK3CG; CYCS

Protein Function

RHOA has several biochemical functions, for example, GDP binding, GTP binding, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RHOA itself. We selected most functions RHOA had, and list some proteins which have the same functions with RHOA. You can find most of the proteins on our site.
Function
Related Protein
Function GDP binding
Related Protein SRP54B; RAB4A; RAB17; RAB18; RAB11B; RAB22A; RAB3B; RAP2B; RAB31; PRPS2
Function GTP binding
Related Protein RHOV; GBP3; ARL4AA; RHOBTB1; TUBA8L4; RAB7; TUBA1B; MXA; RHOU; EEF1A1L2
Function GTPase activity
Related Protein GNG5; RAB20; RHOT1B; RRAS; RAB5AA; RND3; RAN; MXC; MXG; AGAP2
Function Rho GDP-dissociation inhibitor binding
Related Protein RAC1; RHOA
Function myosin binding
Related Protein SLC6A4; FXYD1; VEZT; MYBPC3; CALM; DMD; CALD1B; ACTA1; TRIM32; GIPC1
Function protein binding
Related Protein FRS3; WDR24; MPHOSPH6; GDAP2; FHIT; SLC25A10; RPSA; GABBR2; MYZAP; NASP
Function protein domain specific binding
Related Protein STRN4; LIN7B; STX1A; FOXH1; GABRR2; SKI; FOXA2; Akap2; CAPG; TJP2

Interacting Protein

RHOA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RHOA here. Most of them are supplied by our site. Hope this information will be useful for your research of RHOA.
RTKN; ARHGDIA; DAAM1; ARHGEF11

RHOA Related Articles

Chinestra, P; Olichon, A; et al. Generation of a Single Chain Antibody Variable Fragment (scFv) to Sense Selectively RhoB Activation. PLOS ONE 9:-(2014).
Fichter, CD; Gudernatsch, V; et al. ErbB targeting inhibitors repress cell migration of esophageal squamous cell carcinoma and adenocarcinoma cells by distinct signaling pathways. JOURNAL OF MOLECULAR MEDICINE-JMM 92:1209-1223(2014).