rhoa
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  • Official Full Name
  • ras homolog family member A
  • Background
  • Ras is the name given to a family of related proteins which is ubiquitously expressed in all cells, . All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells (cellular signal transduction). Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours.
  • Synonyms
  • RHOA; ras homolog family member A; ARH12, ARHA, ras homolog gene family, member A; transforming protein RhoA; Rho12; RhoA; RHOH12; h12; oncogene RHO H12; rho cDNA clone 12; Aplysia ras-related homolog 12; small GTP binding protein RhoA; ras homolog gene
Cat.#:RHOA-1182HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human RHOA Protein, MYC/DDK-tagged
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Cat.#:RHOA-1627HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ras Homolog Gene Family, Member A, His-tagged
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Cat.#:RHOA-3372HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ras Homolog Gene Family, His-tagged
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Cat.#:RHOA-1145HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ras Homolog Gene Family, Member A
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Cat.#:RHOA-179HTag:His
Source (Host):BacteriaSpecies:Human
Product nameRecombinant Human RHOA, His-tagged
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Cat.#:RHOA-2290HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RHOA, GST-tagged
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Cat.#:RHOA-27379THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RHOA
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Cat.#:RHOA-313HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human RHOA
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Cat.#:RHOA-32HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RHOA protein, His-tagged
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Cat.#:RHOA-33HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RHOA protein, His-tagged
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Cat.#:RHOA-34HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RHOA protein, GST-tagged
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Cat.#:RHOA-3975HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RHOA, His tagged
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Cat.#:RHOA-5035RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RHOA Protein
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Cat.#:RHOA-6269CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RHOA
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Cat.#:RHOA-1146HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ras Homolog Gene Family, Member A, GST-tagged
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Cat.#:RHOA-601HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RHOA cell lysate
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Cat.#:Kit-0768Tag:
Source (Host):Species:
Product nameRhoA Activation ColorimetricAssay Kit (24 assays)
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Cat.#:Kit-0769Tag:
Source (Host):Species:
Product nameRhoA Activation Colorimetric Assay Kit (96 assays)
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Involved Pathway

RHOA involved in several pathways and played different roles in them. We selected most pathways RHOA participated on our site, such as Ras signaling pathway, Rap signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RHOA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
PLCE1; PIK3R1; FGF16; BAD; INSR; PLA1A; CALML3; KIT; RASAL3; FLT1
Rap signaling pathway
FGF7; PIK3CA; INS2; FGF5; Fgf15; GNAS; HGF; LPAR5; FGF21; IGF1R
cGMP-PKG signaling pathway
NFATC3; ITPR1; PLCB2; NPPB; ATP2A3; RGS2; CALM1; PRKCE; MAP2K2; PDE5A
cAMP signaling pathway
FXYD1; ATP1A4; PRKACB; PDE3A; PLD1; ATP1A3; PLN; VIPR2; VAV2; PDE3B
Chemokine signaling pathway
VAV2; IKBKG; GRK7; BCAR1; HRAS; ROCK1; CXCL11; CXCR1; ARRB1; CCL21
Sphingolipid signaling pathway
GNA12; TRADD; SMPD1; SGPL1; PLCB2; SPTLC1; MS4A2; BDKRB2; PIK3R1; MAPK1
Phospholipase D signaling pathway
PIK3CA; CYTH4; KRAS; SHC4; GAB2; CXCR2; RALGDS; CXCR1; LPAR3; FCER1G
Endocytosis
NEDD4L; PSD4; WASL; CCDC53; CHMP2B; CXCR4A; FOLR1; IST1; CDC42L2; SNX2
Vascular smooth muscle contraction
GNAS; PRKCQ; CALM3; RHOA; MAP2K2B; AVPR1A; MAP2K1; PLCB4; CALM3B; KCNMB1
Wnt signaling pathway
SIAH2L; FZD1; CSNK1A1L; PRKACAB; FZD3A; WNT2B; BTRC; PRKACB; WNT8A; PRKACBA
TGF-beta signaling pathway
RPS6KB1; TGFBR1A; RPS6KB1B; LFT2; RHOAB; ID2B; EP300; INHBA; PPP2CB; THBS1
Axon guidance
RAC2; FRS2B; PPP3R2; SEMA4A; CXCR4; ROCK1; PAQR3A; PPP3CB; CAP1; EPHB3A
Focal adhesion
PAK6B; ITGB1B.2; PAK1; BCL2A; PDGFD; COL4A1; DIAP1; SHC3; COL5A2; SEPP1
Adherens junction
SRC; PTPN6; EGFR; WASLB; WASB; WASF3B; ACTB2; FARP2; LMO7; PTPRFB
Tight junction
MYL9B; GNAI1; NRAS; LLGL1; VAPA; ACTN3B; MYH8; RRAS; PPP2R1B; MAGI2
Platelet activation
ITGA2; PLCB4; PTGS1; PPP1CB; PLCG2; MAPK12; ARHGAP35; PLA2G4A; ITPR3; PTGIR
T cell receptor signaling pathway
Il2; LAT; IFNG; CABIN1; PAK2; GSK3B; TEC; IL4; PRKCQ; NFATC1
Leukocyte transendothelial migration
CLDN4; RAP1A; PIK3CD; CLDN22; PIK3R3; CYBA; CLDN14; PIK3CG; ITGB2; CLDN18
Neurotrophin signaling pathway
MAP3K3; NGFRAP1; ZNF274; ARHGDIA; ARHGDIB; MAP3K5; RPS6KA3; MAP2K7; BAX; PLCG1
Regulation of actin cytoskeleton
BRK1; ARPC5LA; PAK1; GNA13A; DIAP3; MYL10; ACTN3; MYL2; PAK3; PIP5K1AA
Oxytocin signaling pathway
HRAS; TRPM2; MYL6B; PPP1CC; NFATC4; CACNA2D2; PPP1R12A; MAPK3; GUCY1B3; PLCB1
Pancreatic secretion
ITPR3; PLA2G12A; CLCA2; ATP1A2; ATP2A1; SLC9A1; PLA2G1B; ATP2B1; Cel; CD38
Bacterial invasion of epithelial cells
ARPC2; SEPT9; ARPC5L; CBLB; SHC3; ARPC3; ARPC4; ACTG1; CBLC; MAD2L2
Pathogenic Escherichia coli infection
FYN; CD14; TUBB2B; WAS; TUBA4A; KRT18; TUBB2A; TUBA1B; PRKCA; TUBB7P
Pertussis
GNAI3; CALM3; NLRP3; Itgam&Itgb2; FOS; AMCF-II; C4A; GNAI1; IRF1; Casp3
Tuberculosis
SPHK1; CAMK2A; CLEC4M; Il23a; Il12b; CAP18; CASP8; MRC1; IFNA6; MAPK11; RFXANK
Pathways in cancer
APC2; PLCB3; FGFR2; ITGA3; FLT3; FOS; TCF7L2; GNB1; ARNT; IKBKG
Viral carcinogenesis
HIST2H2BB; GSN; BAK1; HIST1H2BF; HDAC4; STAT5A; PKM; CCNE2; HPN; KRAS
Proteoglycans in cancer
MAPK13; IGF1R; CDC42; TP53; SDC1; RPS6; CBL; CCND1; CTTN; PDCD4
MicroRNAs in cancer
NRAS; PRKCG; CDC25A; SOX4; STMN1; HMOX1; BRCA1; VIM; CCNE1; RHOA
Colorectal cancer
ARAF; SMAD3; PIK3R1; KRAS; RALGDS; AXIN2; CCND1; APC; MAPK10; Casp3

Protein Function

RHOA has several biochemical functions, for example, GDP binding, GTP binding, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RHOA itself. We selected most functions RHOA had, and list some proteins which have the same functions with RHOA. You can find most of the proteins on our site.
Function
Related Protein
Function GDP binding
Related Protein RAB5B; RAB5C; RAB8A; RAB40C; RAB12; RAB27A; RAB14; ARF1; RHOB; RAN
Function GTP binding
Related Protein RHOBTB2A; NOLC1; RHOAA; DNM1; RAB34A; IRGE4; SEPT7A; RAB1B; TUBB6; RAB40C
Function GTPase activity
Related Protein GNAIA; TUBB4B; RASL10A; RHOF; SEPT9; RIT2; TUBA8L3; OPA1; GNA13; RAB25
Function Rho GDP-dissociation inhibitor binding
Related Protein RHOA; RAC1
Function myosin binding
Related Protein ARFGEF2; SLC6A4; TRIM32; CALM; DMD; USH2A; FXYD1; VETZ; STX4A; NPHS1
Function protein binding
Related Protein MRAS; ARNTL; RPL37A; SP100; ZNF83; SERPINA3; ZBTB16; GBF1; CHCHD3; RHOT1
Function protein domain specific binding
Related Protein CALM3; YWHAQA; PKD1; CEP68; YWHAE; CSNK2B; CHMP2B; E2F4; GSN; ABCC2

Interacting Protein

RHOA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RHOA here. Most of them are supplied by our site. Hope this information will be useful for your research of RHOA.
RTKN; ARHGDIA; DAAM1; ARHGEF11

RHOA Related Articles

Chinestra, P; Olichon, A; et al. Generation of a Single Chain Antibody Variable Fragment (scFv) to Sense Selectively RhoB Activation. PLOS ONE 9:-(2014).
Fichter, CD; Gudernatsch, V; et al. ErbB targeting inhibitors repress cell migration of esophageal squamous cell carcinoma and adenocarcinoma cells by distinct signaling pathways. JOURNAL OF MOLECULAR MEDICINE-JMM 92:1209-1223(2014).