rhoa
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  • Official Full Name
  • ras homolog family member A
  • Background
  • Ras is the name given to a family of related proteins which is ubiquitously expressed in all cells, . All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells (cellular signal transduction). Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours.
  • Synonyms
  • RHOA; ras homolog family member A; ARH12, ARHA, ras homolog gene family, member A; transforming protein RhoA; Rho12; RhoA; RHOH12; h12; oncogene RHO H12; rho cDNA clone 12; Aplysia ras-related homolog 12; small GTP binding protein RhoA; ras homolog gene
Cat.#:RHOA-1182HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human RHOA Protein, MYC/DDK-tagged
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Cat.#:RHOA-1627HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ras Homolog Gene Family, Member A, His-tagged
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Cat.#:RHOA-3372HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ras Homolog Gene Family, His-tagged
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Cat.#:RHOA-1145HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ras Homolog Gene Family, Member A
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Cat.#:RHOA-179HTag:His
Source (Host):BacteriaSpecies:Human
Product nameRecombinant Human RHOA, His-tagged
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Cat.#:RHOA-2290HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RHOA, GST-tagged
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Cat.#:RHOA-27379THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RHOA
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Cat.#:RHOA-313HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human RHOA
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Cat.#:RHOA-32HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RHOA protein, His-tagged
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Cat.#:RHOA-33HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RHOA protein, His-tagged
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Cat.#:RHOA-34HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RHOA protein, GST-tagged
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Cat.#:RHOA-3975HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RHOA, His tagged
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Cat.#:RHOA-5035RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RHOA Protein
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Cat.#:RHOA-6269CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RHOA
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Cat.#:RHOA-1146HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ras Homolog Gene Family, Member A, GST-tagged
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Cat.#:RHOA-601HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RHOA cell lysate
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Cat.#:Kit-0768Tag:
Source (Host):Species:
Product nameRhoA Activation ColorimetricAssay Kit (24 assays)
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Cat.#:Kit-0769Tag:
Source (Host):Species:
Product nameRhoA Activation Colorimetric Assay Kit (96 assays)
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Involved Pathway

RHOA involved in several pathways and played different roles in them. We selected most pathways RHOA participated on our site, such as Ras signaling pathway, Rap signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RHOA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
RASGRF2; SHC3; KIT; NGF; FLT4; ANGPT2; SHC2; FGF22; PIK3R3; PLA2G4C
Rap signaling pathway
RASGRP3; CALM1; GRIN2A; RAPGEF5; PRKCG; MAP2K2; PLCB2; APBB1IP; IGF1R; IGF1
cGMP-PKG signaling pathway
ATP2B1; ATP2B4; CALM1; RGS2; NFATC2; BAD; MEF2C; OPRD1; NFATC4; KCNJ8
cAMP signaling pathway
ATP1A4; BAD; MAPK9; PPARA; GRIA1; ATP1B2; GABBR1; PPP1CA; PIK3R5; CNGA4
Chemokine signaling pathway
PIK3CD; NFKB1; IKBKB; GNG4; ROCK2; CCL28; AKT1; CCR1; ADRBK1; GNAI1
Sphingolipid signaling pathway
GNAI2; NOS3; SPTLC3; MAPK13; HRAS; BID; PIK3R2; PPP2R2C; SPTLC1; MAPK9
Phospholipase D signaling pathway
PDGFRB; PIK3R2; PIP5K1B; GRM2; AVPR1B; INS2; AGPAT4; FCER1A; CXCR2; DGKZ
Endocytosis
RAB31; ADRB2B; ARPC1B; STAMBP; HSPA1B; ARPC4; LDLRAP1; CLINT1A; ADRB1; TGFBR2
Vascular smooth muscle contraction
ARHGEF12; GUCY1B3; GNA13A; PRKACBA; GUCY1A3; ACTA2; PRKG1; CACNA1DA; CALM4; GNA15.4
Wnt signaling pathway
TBL1X; GSK3AA; VANGL2; PRKACB; PPP3R1B; GPC4; LEF1; WNT3A; SERPINF1; BAMBI
TGF-beta signaling pathway
SMAD2; INHBB; SMAD7B; RPS6KB1; NBL1; CHD; SMAD1; LFT1; INHBE; FSTA
Axon guidance
SRGAP2; CNTN6; MYL12B; NTN1A; COL9A1; UNC5A; KIF4A; NRP2; NTN1; EFNA3
Focal adhesion
CAPN2B; ITGA2B; PTK6; MYLK4; GRB2A; VASP; DIAP1; PRKCA; ARHGAP35; PAK2
Adherens junction
NLK1; WASF3B; RHOAD; TCF7L1A; ACTB; IGF1R; PVRL4; YES1; TGFBR1A; LEF1
Tight junction
VAPA; ACTB2; MPP5A; HRASB; HRAS; HCLS1; PRKCBB; PRKCHA; CLDN19; PPP2CA
Platelet activation
FGB; PLA2G4D; PLCG2; GUCY1A3; GNAS; MAPK3; PRKACG; GNAQ; ITGA2B; STIM1
T cell receptor signaling pathway
IL4; PIK3CG; FYN; MAPK9; PPP3R1; PIK3R3; CD4; CBLB; CBLC; PAK3
Leukocyte transendothelial migration
PIK3R3; ITGB2; ACTB; MMP2; MYL7; PIK3CA; PLCG2; RASSF5; PTK2B; ACTN2
Neurotrophin signaling pathway
GSK3B; ATF4; PDPK1; MAP3K5; CDC42; PIK3R1; RHOA; MAPK8; MAPK10; IRAK1
Regulation of actin cytoskeleton
ARAF; LIMK1A; ABI2B; VAV1; PIK3R3; FGF5; SSH2; FN1; ITGB2; PIK3R3A
Oxytocin signaling pathway
MYLK3; CACNB1; PIK3R5; OXT; MYLK4; CCND1; MAPK3; PRKAG1; ELK1; PPP1R12C
Pancreatic secretion
ATP1A4; GNAQ; Cel; ATP1B1; PLA2G2E; PLA2G12B; PRSS3; PLA2G2D; CELA2A; ATP1A1
Bacterial invasion of epithelial cells
CDC42; BCAR1; SEPT11; CBL; RHOA; MAD2L2; RAC1; HCLS1; CBLC; ARPC2
Pathogenic Escherichia coli infection
TUBA1C; TUBB2B; WASL; ACTB; TUBA3C; CTTN; ARHGEF2; KRT18; TUBAL3; NCK1
Pertussis
IRAK4; GNAI2; Hc; C1QA; ITGB2; C2; CD14; IL1B; C1RA; C5
Tuberculosis
CALML3; PPP3R1; IRAK1; Itgam&Itgb2; RAB7A; IFNA2; CAMK2G; RFXAP; MRC2; ARHGEF12
Pathways in cancer
SOS1; RUNX1T1; ARNT; PIK3CG; PRKCA; MSH3; RAD51; RAC3; IGF1; WNT11
Viral carcinogenesis
IL6ST; HIST1H4B; MDM2; MAPKAPK2; GTF2E2; TBPL1; TRP53; UBR4; YWHAZ; C3
Proteoglycans in cancer
FZD1; FASLG; RRAS2; PTPN6; MSN; IGF1; ITGB5; PTK2; TGFB2; PDCD4
MicroRNAs in cancer
MDM2; FOXP1; TIMP3; NOTCH2; MAPK1; RHOA; SERPINB5; DNMT3B; BMPR2; GRB2
Colorectal cancer
RAC2; PIK3CD; ARAF; TCF7; RAF1; TP53; RHOA; BAX; MSH6; MSH2

Protein Function

RHOA has several biochemical functions, for example, GDP binding, GTP binding, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RHOA itself. We selected most functions RHOA had, and list some proteins which have the same functions with RHOA. You can find most of the proteins on our site.
Function
Related Protein
Function GDP binding
Related Protein SEPT12; RAB7L1; SRP54A; RAB2A; RAP2C; SRP54B; RRAGC; RAB40C; RAB17; RAB11B
Function GTP binding
Related Protein ACSM1; ARF4A; GIMAP8; SEPT1; TUBB1; RAP1B; TUBA1L2; SEPHS1; RAB12; RHEBL1
Function GTPase activity
Related Protein TUBA8L2; RAB32A; RAB39B; RABL2A; RAB11BB; GNA12; RAB25A; TUBB6; GNB5; RAB6B
Function Rho GDP-dissociation inhibitor binding
Related Protein RHOA; RAC1
Function myosin binding
Related Protein VAMP2; STX4A; ARFGEF1; SLC6A4; ARFGEF2; CALM; DMD; CALD1B; GIPC1; ACTA1
Function protein binding
Related Protein TBC1D23; MAPK15; PLK1S1; CAMK1; CHST13; EPHB2; SUV39H2; SLC22A5; ARF5; MALL
Function protein domain specific binding
Related Protein ZFP521; HIST1H4F; PRKCZ; ACSL3; ZNF521; VAPA; FOXH1; ARL1; ICA1L; LIN7B

Interacting Protein

RHOA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RHOA here. Most of them are supplied by our site. Hope this information will be useful for your research of RHOA.
RTKN; ARHGDIA; DAAM1; ARHGEF11

RHOA Related Articles

Chinestra, P; Olichon, A; et al. Generation of a Single Chain Antibody Variable Fragment (scFv) to Sense Selectively RhoB Activation. PLOS ONE 9:-(2014).
Fichter, CD; Gudernatsch, V; et al. ErbB targeting inhibitors repress cell migration of esophageal squamous cell carcinoma and adenocarcinoma cells by distinct signaling pathways. JOURNAL OF MOLECULAR MEDICINE-JMM 92:1209-1223(2014).