Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

MED7

  • Official Full Name

    mediator complex subunit 7

  • Overview

    The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene.
  • Synonyms

    MED7; mediator complex subunit 7; cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa , CRSP9; mediator of RNA polymerase II transcription subunit 7; CRSP33; Activator recruited cofactor 34 kDa component; ARC34; Cofactor required for Sp1 transcriptional activation subunit 9; MGC12284; RNA polymerase transcriptional regulation mediator subunit 7 homolog; Transcriptional coactivator CRSP33; hMED7; OTTHUMP00000160735; CRSP complex subunit 9; activator-recruited cofactor 34 kDa component; RNA; CRSP9;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MED7-1910H Recombinant Human MED7 Protein, GST-tagged Wheat Germ GST
Human MED7-26939TH Recombinant Human MED7 N/A
Human MED7-4379HCL Recombinant Human MED7 293 Cell Lysate HEK293 N/A
Human MED7-1121H Recombinant Human MED7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MED7-2110HF Recombinant Full Length Human MED7 Protein, GST-tagged In Vitro Cell Free System GST 233 amino acids
Mouse MED7-9706M Recombinant Mouse MED7 Protein Mammalian Cell His
Mouse MED7-5462M Recombinant Mouse MED7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MED7-5462M-B Recombinant Mouse MED7 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MED7-10132Z Recombinant Zebrafish MED7 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MED7 Related Articles

MED7 involved in several pathways and played different roles in them. We selected most pathways MED7 participated on our site, such as Developmental Biology, Fatty acid, triacylglycerol, and ketone body metabolism, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Developmental BiologyGPC1B;EFNA3;FGF8B;MYL12B;EFNB3B;LGI2A;COL9A1B;LIN28A;SCN3B
Fatty acid, triacylglycerol, and ketone body metabolismMED19;ACOT7;PLIN2;AGPAT6;ACOT10;MED15;Agmo;ACOT9;AGPAT2
Gene ExpressionGTF3AB;FARSB;ZNF557;HNRNPR;ZNF671;SUZ12A;KARS;ZNF354A;ZNF446
Generic Transcription PathwayZNF658;ARHGEF38;MED16;NR1I2;COX14;ZNF530;ZKSCAN3;KRBOX4;ZNF839
MetabolismDGAT1B;CYP2AD3;NUDT15;CYP46A1;D2HGDH;PITPNB;SLC5A9;TYMP;DPEP2
Metabolism of lipids and lipoproteinsPHOSPHO1;PNPLA8;ACOT11B;CYP2V1;SGMS2;ACOT12;CEPT1A;CYP2AD6;PPM1LA
PPARA activates gene expressionMED16;MED26;MED29;MED20;MED22;MED9;MED25;MED21;ANKRD1
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)MED15;GLIPR1;MED16;MED18;MED6;CTGF;MED10;MTF1;MED19

MED7 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity, protein binding, transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED7 itself. We selected most functions MED7 had, and list some proteins which have the same functions with MED7. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II transcription cofactor activityNKX2-5;CNOT2;MED20;FOXH1;MED11;MED21;MED19B;MED18;PPARGC1B
protein bindingMAPKBP1;SPTSSB;WBP2NL;GRIP1;PRICKLE1A;NPC2;CD2BP2;TTC32;FGF1
transcription coactivator activityTAF5L;JUND;SCAND1;CREBBP;NACA;MAK;PRMT2;NPM1;WNT3A
ubiquitin protein ligase activityHECW1;RBX1;UBE2U;UBE2V1;ARIH1L;CCNC;RNF175;RNF144AB;UBE2T

MED7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED7 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED7.

MED10; MED26; MED19; env; CDK19; MED9

Kurita, H; Schnekenburger, M; et al. The Ah Receptor Recruits IKK alpha to Its Target Binding Motifs to Phosphorylate Serine-10 in Histone H3 Required for Transcriptional Activation. TOXICOLOGICAL SCIENCES 139:121-132(2014).
Sendler, M; Dummer, A; et al. Tumour necrosis factor alpha secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice. GUT 62:430-439(2013).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All MED7 Products

Required fields are marked with *

My Review for All MED7 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends