RNF111 Protein, ring finger protein 111


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Official Full Name ring finger protein 111
Background The protein encoded by this gene contains a RING finger domain, a motif known to be involved in protein-protein and protein-DNA interactions. The mouse counterpart of this gene (Rnf111/arkadia) has been shown to genetically interact with the transforming growth factor (TGF) beta-like factor Nodal, and act as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development.
Synonyms RNF111; ring finger protein 111; E3 ubiquitin-protein ligase Arkadia; ARK; Arkadia; DKFZP761D081; FLJ38008; DKFZp313E0731; DKFZp686H1966
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RNF111-1516HCL Recombinant Human RNF111 cell lysate N/A
    Human RNF111-2333H Recombinant Human RNF111, His-tagged E.coli His
    Mouse RNF111-14285M Recombinant Mouse RNF111 Protein Mammalian Cell His
    Chicken RNF111-4474C Recombinant Chicken RNF111 Mammalian Cell His
    Zebrafish RNF111-8357Z Recombinant Zebrafish RNF111 Mammalian Cell His

    RNF111 involved in several pathways and played different roles in them. We selected most pathways RNF111 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF111 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System RNF19B; AKT3; DYNC1I2; KLHL21; NPEPPS; ASB8; AP2S1; HUWE1; AMICA1; ITK
    Antigen processing: Ubiquitination &amp PJA1; ASB11; TPP2; SPSB4; RNF6; UFL1; GAN; ASB2; WWP1; RNF111
    Proteasome degradation VPRBP; DTX3L; KLHL20; LRSAM1; SH3RF1; FBXO44; UBE2E3; UBE2J2; RNF14; UBA5
    Class I MHC mediated antigen processing &amp ASB6; HUWE1; ASB11; ASB2; UBE2L6; LRRC41; TRIM11; ASB7; CYBB; UBR1
    presentation KLHL21; SEC61B; PJA2; ASB17; TRIM39; DTX3L; RNF19B; PJA1; ERAP2; CD207
    Downregulation of SMAD2/3:SMAD4 transcriptional activity USP9; SKILB; SKIA; SKI; SMAD3B; TRIM33; PARP1; RNF111; USP9X; SKIB
    Formation of Incision Complex in GG-NER CHD1L; DDB1; USP45; DDB2; PIAS3; PARP2; RNF111; CETN2
    Gene Expression CD3EAP; ZNF596; UHRF1; COX6A1; COX8A; TSN; ZNF530; ZNF2; QTRT1; SETB
    Generic Transcription Pathway NR1I2; ZNF133; ZNF180; ZNF192; NR1H3; ZNF740; ZNF286A; Txn1; COX16; TUBB3

    RNF111 has several biochemical functions, for example, SMAD binding, SUMO polymer binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF111 itself. We selected most functions RNF111 had, and list some proteins which have the same functions with RNF111. You can find most of the proteins on our site.

    Function Related Protein
    SUMO polymer binding RNF222; SOBP; RNF111; RNF4; SIMC1
    ligase activity TRIM11; UHRF2; UBE2NA; RBBP6; RING1; IRF2BP1; SIAH1; UBE2KB; SH3RF2; CNOT4
    protein binding ZBTB33; ZG16; GIT2; TBX15; TIMM23; CD151; EYA4; CRTC2; TPRKB; HSBP1
    ubiquitin protein ligase activity MED27; MARCH1; UBE3A; RNF41; UBE2G1; TRIM32; AMFR; TRIM3; TRIM6; RNF19B
    zinc ion binding KIAA0913; GATA2B; TEX13A; DTX4; SH3RF3; AGTPBP1; XIAP; TRIM27; ADH1; DEF8

    RNF111 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF111 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF111.

    UBE2D1; UBE2D3; UBE2I; KRTAP5-9; CSNK2A1

    Jimeno, S; Fernandez-Avila, MJ; et al. Neddylation inhibits CtIP-mediated resection and regulates DNA double strand break repair pathway choice. NUCLEIC ACIDS RESEARCH 43:987-999(2015).
    Sun, HY; Liu, YJ; et al. Multiple Arkadia/RNF111 Structures Coordinate Its Polycomb Body Association and Transcriptional Control. MOLECULAR AND CELLULAR BIOLOGY 34:2981-2995(2014).

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