RNF168
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Official Full Name
ring finger protein 168, E3 ubiquitin protein ligase
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Overview
This gene encodes an E3 ubiquitin ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in DNA double-strand break (DSB) repair. Mutations in this gene result in Riddle syndrome. -
Synonyms
RNF168; ring finger protein 168, E3 ubiquitin protein ligase; ring finger protein 168; E3 ubiquitin-protein ligase RNF168; FLJ35794; FLJ39749;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- Mouse
- Zebrafish
- Baculovirus-Insect cells
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- GST
- His
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- RNF168 Related Research Area
RNF168 involved in several pathways and played different roles in them. We selected most pathways RNF168 participated on our site, such as Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF168 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell Cycle | MSH4;UIMC1;FOXM1;KIF18A;DYRK1A;CEP152;MPEG1;NEK7;TGFB3 |
| Cell Cycle Checkpoints | CHEK2;RNF168;CDK2;RAD9B;HTATIP;HIST4H4;UBE2V2;CHEK1;KAT5 |
| DNA Double Strand Break Response | TP53BP1;SMARCA5;HTATIP;BRCC3;EYA2;RAD50;BARD1;EYA3;UIMC1 |
| DNA Double-Strand Break Repair | RHNO1;RAD50;WRN;THRSP;GEN1;RNF168;EYA3;PARP2;KIAA0146 |
| DNA Repair | CLSPN;RAD51AP1;KIAA0146;ASCC1;WRN;RAD9A;RHNO1;COPS4;POLD3 |
| G2/M Checkpoints | FAM175A;BABAM1;RAD1;RAD9B;UIMC1;BARD1;RAD17;RAD9A;TP53BP1 |
| G2/M DNA damage checkpoint | BABAM1;FAM175A;TP53BP1;RNF168;THRSP;UIMC1;BRCC3;BRE;BARD1 |
| HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) | TP53BP1;EME2;PPP4R2A;RAD9;UIMC1;KIAA0146;BABAM1;RBBP8;PPP4CA |
RNF168 has several biochemical functions, for example, K63-linked polyubiquitin binding, chromatin binding, histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF168 itself. We selected most functions RNF168 had, and list some proteins which have the same functions with RNF168. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| K63-linked polyubiquitin binding | SQSTM1;ZRANB1;PRPF8;TNFAIP3;UIMC1;SPRTN;TAB2;RNF168;RNF169 |
| chromatin binding | CDCA5;SIN3A;FLI1;SMC1A;ING2;SMAD6;JDP2;ANKRD17;DNMT3B |
| histone binding | HIST1H4M;SNCA;PHF21A;HIST1H4D;HINFP;HIST1H4A;NFKBIL2;USP16;ATRX |
| ligase activity | ATG10;SMURF2;RNF25;PET112L;TRIM27;UNKL;ACSL1;HECW1B;ARIH1 |
| nucleosome binding | MUM1;NOC2L;ZNHIT1;ARID1A;DNTTIP1;SMARCA5;RNF169;RNF4;RNF168 |
| protein binding | SNAI1;ZMYM4;MOB4;CEP350;DNAJA1;MRC2;CALB1;RALB;TAF6L |
| ubiquitin binding | TOP2A;FAM125A;SPRTN;FAN1;NPLOC4;USP16;OTUB1;FAF1;CRY2 |
| ubiquitin-protein transferase activity | NLRC4;LNX2B;UBR4;SKP1;UBE2D1;FBXL14B;UBR3;TRIM62;MARCH6 |
| zinc ion binding | PHRF1;SNAI1A;ZFR;LMCD1;PDLIM1;RNF2;RAG2;GATAD1;TAB2 |
RNF168 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF168 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF168.
UBB; GTF2F2; UBE2N; UBE2G2; LAPTM5; RNF11; PSMD11; UBR5; TBP; TRIP12; CCDC174; SRCAP; RNF169; FAM45A; RPRD1B; NUB1; TACC3; H2AFX
- Q&As
- Reviews
Q&As (5)
Ask a questionClinical trials investigating the potential use of RNF168 as a target for cancer therapy or as a biomarker for cancer prognosis may be underway, but specific details would need to be checked.
RNF168 plays a role in initiating a signaling cascade that leads to the recruitment of other DNA repair proteins to the site of DNA damage, promoting repair and maintaining genomic stability.
RNF168 interacts with various proteins involved in the DNA damage response, such as 53BP1 and BRCA1, to coordinate the repair of DNA lesions and maintain genomic stability.
Yes, inherited mutations in the RNF168 gene can increase the risk of developing certain cancers, particularly those associated with DNA damage and repair deficiencies.
The potential side effects and toxicities of targeting RNF168 in cancer therapy are still being explored, and would depend on the specific approach and modality used.
Customer Reviews (3)
Write a reviewNot only does it provide reliable and consistent results due to its high quality and purity, but it also holds significant value in understanding cellular processes and disease mechanisms.
This commitment to excellence ensures that researchers are provided with the most advanced and reliable tools for their investigations.
the RNF168 protein offers numerous advantages in trials and research experiments.
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