RNF168 Protein, ring finger protein 168, E3 ubiquitin protein ligase


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Official Full Name ring finger protein 168, E3 ubiquitin protein ligase
Background This gene encodes an E3 ubiquitin ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in DNA double-strand break (DSB) repair. Mutations in this gene result in Riddle syndrome.
Synonyms RNF168; ring finger protein 168, E3 ubiquitin protein ligase; ring finger protein 168; E3 ubiquitin-protein ligase RNF168; FLJ35794; FLJ39749
    • Species :
    • Human
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RNF168-30H Recombinant Human RNF168, GST-tagged Wheat Germ GST
    Human RNF168-1520HCL Recombinant Human RNF168 cell lysate N/A
    Human RNF168-2338H Recombinant Human RNF168, GST-tagged E.coli GST
    Human RNF168-679H Recombinant Human RNF168 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Zebrafish RNF168-10228Z Recombinant Zebrafish RNF168 Mammalian Cell His

    RNF168 involved in several pathways and played different roles in them. We selected most pathways RNF168 participated on our site, such as Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF168 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell Cycle CDK1; VRK1; FGFR1OP; ENSA; TRP53; NEK7; KIF20A; NEK2; TEX15; HIST4H4
    Cell Cycle Checkpoints KAT5; BRCC3; DBF4; CDK5RAP2; BABAM1; TP53BP1; THRSP; CHEK1; UBE2V2; BRE
    DNA Double Strand Break Response TP53BP1; BABAM1; SMARCA5; BRCC3; HTATIP; KDM4B; BRE; UIMC1; RAD50; CHEK2
    DNA Double-Strand Break Repair RAD9B; PPP4R2; DNA2; GEN1; EYA3; TDP1; CLSPN; RAD9A; RAD51AP1; TP53BP1
    DNA Repair MCRS1; RAD9A; MAD2L2; KIAA1530; CHD1L; ALKBH3; BARD1; YY1; COPS3; USP45
    G2/M Checkpoints RAD17; THRSP; RAD9B; RNF168; FAM175A; TP53BP1; BRE; BARD1; RAD9A; UIMC1
    G2/M DNA damage checkpoint FAM175A; BARD1; BRE; RNF168; THRSP; TP53BP1; UIMC1; BRCC3; BABAM1
    HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) GEN1; HUS1; EME1; EME2; BRE; RNF4; BABAM1; RBBP8; TP53BP1; RAD9B

    RNF168 has several biochemical functions, for example, K63-linked polyubiquitin binding, chromatin binding, histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF168 itself. We selected most functions RNF168 had, and list some proteins which have the same functions with RNF168. You can find most of the proteins on our site.

    Function Related Protein
    K63-linked polyubiquitin binding ZRANB1; PRPF8; ZRANB1B; SQSTM1; TNFAIP3; IKBKG; RNF168; ATRIP; ZRANB3; TAB2
    chromatin binding PKN1; SOX9A; NCOA3; FOXO1; PRDM11; CAMTA2; FABP1; BRD3; WHSC1; TICRR
    histone binding USP3; PYGO2; HIST1H4M; ASF1A; HJURP; HIST1H4F; ELP2; SET; HIST1H4N; RCC1
    ligase activity KCMF1; HLTF; BIRC7; RNF181; UBE2NB; RNF185; RNF152; PIAS1; RNF4; NEDD4L
    nucleosome binding RNF4; L3MBTL1; ARID1A; HP1BP3; MUM1; NOC2L; DNTTIP1; SMARCA5; ZNHIT1; RNF169
    protein binding LACTB2; CCND3; SNRPB; ZFP423; NSMCE1; CHMP5; TAB1; PELI1; C19orf80; RTN1
    ubiquitin binding FAF1; IDE; DYRK2; OTUB2; USP25; RNF168; RBCK1; DNAJC2; TNFAIP3; IWS1
    ubiquitin-protein transferase activity TRIM33; MARCH8; HECW1B; RNF220; BTR22; PDZRN3B; TRAF2; TRIM24; TRAF4; ITCH
    zinc ion binding BTR12; RYBPB; RLIM; VPS41; NR5A1; MMP13A; TRIM35-27; SQSTM1; RNF149; CA7

    RNF168 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF168 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF168.


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