|Official Full Name||ring finger protein 20, E3 ubiquitin protein ligase|
|Background||The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012]|
|Synonyms||RNF20; ring finger protein 20, E3 ubiquitin protein ligase; BRE1; BRE1A; hBRE1; E3 ubiquitin-protein ligase BRE1A; BRE1-A; homolog of S. cerevisiae BRE1; BRE1 E3 ubiquitin ligase homolog;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
RNF20 involved in several pathways and played different roles in them. We selected most pathways RNF20 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF20 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
RNF20 has several biochemical functions, for example, chromatin binding, histone binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF20 itself. We selected most functions RNF20 had, and list some proteins which have the same functions with RNF20. You can find most of the proteins on our site.
|chromatin binding||PHF13; KLHDC3; TGIF1; SIRT6; ATOH1A; ARX; HMG20A; KLF14; PPARGC1A; ATAD2|
|histone binding||HIST1H4M; JAK2; PIH1D1; UIMC1; NCAPD3; HIST1H4D; USP16; HIST1H4B; HIST2H3C; PRMT7|
|ligase activity||MARCH1; TTLL11; TTC3; TRIM39; TRIM71; PARK2; RAG1; NSMCE2; TTLL6; UBE3C|
|mRNA 3-UTR binding||SERBP1; RBM24; CPEB1A; HNRNPC; CSDA; TUT1; CPEB2; RNPS1; PPP1R2P9; ELAVL1|
|p53 binding||BCL2L12; SETD8; TRP63; BLM; BANP; USP10; ZFP346; BRD4; TP63; EP300|
|protein binding||HNRNPU; TRIM31; MTMR6; DPH1; POLD4; GLIS2; TAF9; ARHGEF10; GPR3; TBC1D1|
|transcription coactivator activity||NFKB2; TAF7; MAGED1; EDF1; USP22; CITED1; CCAR1; TDRD3; KAT2A; PER2|
|ubiquitin protein ligase binding||PCBP2; ACTG1; TCP1; VCP; BCL10; ERBB2; USP25; YWHAZ; MDM2; MAGEC2|
|ubiquitin-protein transferase activity||ITCHA; RFWD3; MARCH5; RNF41; RNF168; RNF135; WWP1; MARCH6; HACE1; MIB2|
|contributes_to ubiquitin-protein transferase activity||KLHL13; TCEB3; KBTBD13; FBXL3; KLHL12; KLHL24; KLHL17; KLHL1; BARD1; KLHL10|
|zinc ion binding||MORC4; RNF144AA; SH3RF2; PHC2A; CXXC4; ADAMTS20; HLTF; PDLIM3A; RERE; SIAH2|
RNF20 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF20 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF20.
RNF40; USHBP1; AMOTL2; HTT; UBE2A