|Official Full Name||ribosomal protein L7|
|Background||Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.|
|Synonyms||RPL7; ribosomal protein L7; 60S ribosomal protein L7; humL7 1; L7; RL7_HUMAN; RPL 7; Rpl7a; Surf 3; OTTHUMP00000166002; OTTHUMP00000166003; OTTHUMP00000166004; OTTHUMP00000166005; humL7-1|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
RPL7 involved in several pathways and played different roles in them. We selected most pathways RPL7 participated on our site, such as Ribosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPL7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Ribosome||RPL22L1; RPL15; MRPL3; RPL27; RPL18A; MRPL13; RPL6; RPS4X; RPL35A; RPL3L|
RPL7 has several biochemical functions, for example, DNA binding, RNA binding, mRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPL7 itself. We selected most functions RPL7 had, and list some proteins which have the same functions with RPL7. You can find most of the proteins on our site.
|DNA binding||ZKSCAN14; POU3F2B; HIST1H4E; IRX2A; POU6F2; NR4A2B; TOP1; ING2; ZEB1B; HOXD9A|
|RNA binding||RBM15B; RPL7; KHDRBS1B; PUSL1; RTCD1; RBM14; ARHGEF28; RPL13; EIF4E2RS1; RBM4B|
|mRNA binding||RBM8A; THOC2; TDRD7; RPS13; PAIP2; PIWIL1; RPS3; CPSF5; ELAVL1; EIF4A1|
|poly(A) RNA binding||ETF1; OASL1; CDC5L; EIF4A2; RPS16; CSTF1; EIF4H; C14orf166; OASL; U2AF2|
|protein binding||SH3BP4; CLK4; ICAM3; OLR1; TMED10; GNB5; SCARB2; SPG21; VAMP8; PRKD3|
|protein homodimerization activity||NKX2-5; GSTM1; PYGL; PPP2R4; USF2; GTF2A2; LGALS6; BMPR1A; KCNK9; KLRB1B|
|structural constituent of ribosome||MRPS15; RPS4Y1; MRPL47; MRPL52; MRPL46; RPL5; MRPS12; RPS14; MRPL13; MRPL55|
RPL7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPL7 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPL7.
IPO5; NEDD8; ESR1; ESR2; ACTB; RAN; NFKB2; RELA; MAP3K1; NFKBIB; USP38; MAP3K14; TBK1; NR4A1