rpl7
Share
  • Official Full Name
  • ribosomal protein L7
  • Background
  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
  • Synonyms
  • RPL7; ribosomal protein L7; 60S ribosomal protein L7; humL7 1; L7; RL7_HUMAN; RPL 7; Rpl7a; Surf 3; OTTHUMP00000166002; OTTHUMP00000166003; OTTHUMP00000166004; OTTHUMP00000166005; humL7-1
Cat.#:RPL7-31336THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RPL7, His-tagged
+Inquiry
Cat.#:RPL7-14447MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RPL7 Protein
+Inquiry
Cat.#:RPL7-882CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus RPL7 Protein, His-tagged
+Inquiry
Cat.#:RPL7-1489CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RPL7
+Inquiry
Cat.#:RPL7-12709ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RPL7
+Inquiry

Involved Pathway

RPL7 involved in several pathways and played different roles in them. We selected most pathways RPL7 participated on our site, such as Ribosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPL7 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ribosome
RPS28; MRPL14; MRPL23; RPL34; RPLP2; RPS10; MRPS10; MRPL33; RPS12; RPS4Y2

Protein Function

RPL7 has several biochemical functions, for example, DNA binding, RNA binding, mRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPL7 itself. We selected most functions RPL7 had, and list some proteins which have the same functions with RPL7. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein VDRA; FANCI; ZNF2; ZNF692; JUNBA; SIM1; ZNF563; ZNF789; CHRAC1; PRM3
Function RNA binding
Related Protein SAMHD1; RPL27A; PAPOLA; DIS3L; SUPV3L1; RBM18; TARDBP; TERT; SMN2; GTF3A
Function mRNA binding
Related Protein LIN28A; RBM38; ITM2B; NXF2; CELF1; ZFP36L1; SRRM4; MRPL13; MRPS7; DHFR
Function poly(A) RNA binding
Related Protein WDR6; ZFP36; FTSJ3; GTL3; RTCD1; BCCIP; OTUD4; RPL32; MRPL39; DHX15
Function protein binding
Related Protein SEC13; RAB35; CREB5; OGG1; HER5; AGO3; USH1G; EDNRA; RNH1; ATP6V1C1
Function protein homodimerization activity
Related Protein RRAGA; Flt3l; Trl; ZBTB1; SLC22A1; NFKB1; TARS; APOA4; DSCAML1; PVRL1
Function structural constituent of ribosome
Related Protein RPL34; RPL10; MRPL4; RPL36; RPS13; RPL13A; RPL6; MRPL34; MRPS5; RPS15

Interacting Protein

RPL7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPL7 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPL7.
IPO5; NEDD8; ESR1; ESR2; ACTB; RAN; NFKB2; RELA; MAP3K1; NFKBIB; USP38; MAP3K14; TBK1; NR4A1