rps6ka2
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  • Official Full Name
  • ribosomal protein S6 kinase, 90kDa, polypeptide 2
  • Background
  • This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
  • Synonyms
  • RPS6KA2; ribosomal protein S6 kinase, 90kDa, polypeptide 2; RSK; HU-2; RSK3; p90-RSK3; pp90RSK3; MAPKAPK1C; S6K-alpha; S6K-alpha2; ribosomal protein S6 kinase alpha-2; RSK-3; p90RSK2; p90-RSK 2; MAPKAPK-1c; S6K-alpha-2; MAPKAP kinase 1c; ribosomal S6 kinase 3; MAPK-activated protein kinase 1c; ribosomal protein S6 kinase alpha 2; 90 kDa ribosomal protein S6 kinase 2; MAP kinase-activated protein kinase 1c; ribosomal protein S6 kinase 90kDa polypeptide 2;
Cat.#:RPS6KA2-2433HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RPS6KA2, His-tagged
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Cat.#:RPS6KA2-426HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RPS6KA2, GST-tagged, Active
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Cat.#:RPS6KA2-961HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RPS6KA2, GST tagged
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Cat.#:RPS6KA2-887CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus RPS6KA2 Protein, His-tagged
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Cat.#:RPS6KA2-610HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RPS6KA2 cell lysate
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Involved Pathway

RPS6KA2 involved in several pathways and played different roles in them. We selected most pathways RPS6KA2 participated on our site, such as MAPK signaling pathway, Oocyte meiosis, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6KA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
RELB; TNFRSF1A; GRB2B; NTF3; NF1; CACNA1C; FGF13; MAP3K13; PPM1AB; ARRB2B
Oocyte meiosis
PPP3CB; PPP2CA; CTH1; FBXO43; RPS6KA2; CPEB1B; CDC23; CAMK2G; MAPK12; INSB
mTOR signaling pathway
VEGFAA; PRKCB; MAPK1; TSC1; RRAGC; MTOR; RPS6KA3A; TSC1B; CAB39L; PIK3CG
Long-term potentiation
PRKACG; PPP1R1A; CAMK2D; RAP1B; RPS6KA6; GRIA2; PRKCA; GRIN2C; ARAF; ITPR1
Neurotrophin signaling pathway
YWHAE; RPS6KA2; CALML5; RAP1B; HRAS; RIPK2; RPS6KA1; PSEN2; MAPK12; BAX
Progesterone-mediated oocyte maturation
CPEB1A; ANAPC1; PIK3CD; FZR1; MAD1L1; PRKACA; ADCY1A; MAPK14B; FZR1A; GNAI3
Insulin resistance
GYS2; INS; NOS3; SLC2A4; PRKAB1B; TBC1D4; PPP1R3A; NFKBIAB; SLC2A1A; SOCS3

Protein Function

RPS6KA2 has several biochemical functions, for example, ATP binding, magnesium ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6KA2 itself. We selected most functions RPS6KA2 had, and list some proteins which have the same functions with RPS6KA2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein UBE2E2; BMPR1AA; WRNIP1; VMHC; WEE1; MYO9B; CENPE; ALDH18A1; ERBB3B; TYK2
Function magnesium ion binding
Related Protein MTPAP; NUDT18; RPS6KA2; RPS6KA4; RPS6KA6; PRPS1L1; STK38; RPS6KAL; ADPRH; NT5C3B
Function protein binding
Related Protein ALK; FAM207A; FAM124A; ALKBH8; ADAM15; PFKM; RARRES3; TAF10; METTL21C; COMMD1
Function protein serine/threonine kinase activity
Related Protein NEK1; STK16; CDC42BPA; CSNK1A1L; DYRK3; RPS6KA5; GRK1A; BCKDK; SLC14A2; AURKA
Function protein serine/threonine/tyrosine kinase activity
Related Protein CLK1; DYRK4; TESK1; PRKCG; AURKA; PRKACA; RPS6KA1; DYRK1AA; AKT1; MAP2K2
Function ribosomal protein S6 kinase activity
Related Protein RPS6KA2; RPS6KA4; RPS6KB2; RPS6KA3; RPS6KA1; RPS6KA3A; ALPK2; RPS6KA6; RPS6KA3B; RPS6KB1

Interacting Protein

RPS6KA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6KA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6KA2.
MAPK3; MAPK1; saicar; PKM; RPS6; HSP90AB1; BRAF; PRKCA; PRKCE; CSNK2B; FLNC; 15-deoxy-delta(12,14; bosutinib; imatinib; GRSF1; FAT1