scmh1
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  • Official Full Name
  • sex comb on midleg homolog 1
  • Background
  • Polycomb protein SCMH1 is a protein that in humans is encoded by the SCMH1 gene.
  • Synonyms
  • SCMH1; sex comb on midleg homolog 1 (Drosophila); polycomb protein SCMH1; Scml3
Cat.#:SCMH1-2534HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SCMH1, GST-tagged
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Cat.#:SCMH1-28619THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SCMH1, His-tagged
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Cat.#:SCMH1-14750MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SCMH1 Protein
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Cat.#:SCMH1-5587ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SCMH1
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Cat.#:SCMH1-2033HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human SCMH1 293 Cell Lysate
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Involved Pathway

SCMH1 involved in several pathways and played different roles in them. We selected most pathways SCMH1 participated on our site, such as Cellular Senescence, Cellular responses to stress, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCMH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cellular Senescence
ACD; E2F2; RBBP4; CBX6; CDKN2B; UBN1; PHC1; BMI1A; MOV10; HIST1H1D
Cellular responses to stress
HIF1AL; BMI1B; WDR45; EED; CBX8A; AGO1; RAD50; IGFBP7; CABIN1; RBBP7
Metabolism of proteins
ARL2; CTDSP2; ARSF; C19orf10; PPP6R3; B3GALTL; TRAPPC6B; GALNT5; SLC30A8; CMA1
Oxidative Stress Induced Senescence
CBX4; PHC3; PHC2; BMI1B; RNF2; BMI1A; KDM6B; SUZ12A; SUZ12; CBX8
Post-translational protein modification
TRAPPC1; B3GNT8; SPON1; MGAT4A; MUC5AC; ST6GAL2B; GNE; SEC22A; ST6GALNAC2; MCFD2
SUMO E3 ligases SUMOylate target proteins
RING1; NSMCE4A; CBX4; NSMCE2; SMC5; RNF2; SCMH1; PHC1; SMC6; NSMCE1
SUMOylation
SCMH1; UBA2; PHC2; SENP1; SMC5; SENP5; EID3; NSMCE1; NSMCE4A; CBX8
SUMOylation of DNA damage response and repair proteins
PHC3; RNF2; NSMCE4A; SCMH1; PHC2; NSMCE2; PHC1; SMC5; SMC6; NSMCE1

Protein Function

SCMH1 has several biochemical functions, for example, DNA binding, protein binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SCMH1 itself. We selected most functions SCMH1 had, and list some proteins which have the same functions with SCMH1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein POLRMT; NR1D4A; ORC6L; INSM1A; FOXJ1B; NABP2; SIX6; HNRNPU; ATM; DHX58
Function protein binding
Related Protein PELI3; VPS8; MAVS; PRKRIR; TBK1; KRTAP10-7; FOXO3; GTF2H2C_2; GPR37L1; RELL2
Function transcription factor activity, sequence-specific DNA binding
Related Protein DEAF1; ZNF155; ATF5; RUNX1; MYRFL; SLC26A3; PRRX2; ZFP629; ZFP28; CNBP

Interacting Protein

SCMH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCMH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SCMH1.
MAGEA12; UBQLN1; UBQLN1; LYPLA2; TMEM11; HK1; TOB1; GRINL1A; PHC2; UBQLN4; MOB4; Bmi1; Cbx2

SCMH1 Related Articles

Takada, Y; Isono, KI; et al. Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes. DEVELOPMENT 134:579-590(2007).
Sathyamurthy, A; Allen, MD; et al. Crystal structure of the malignant brain tumor (MBT) repeats in Sex Comb on Midleg-like 2 (SCML2). JOURNAL OF BIOLOGICAL CHEMISTRY 278:46968-46973(2003).