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SCMH1

Official Full Name

sex comb on midleg homolog 1
Overview

Polycomb protein SCMH1 is a protein that in humans is encoded by the SCMH1 gene.
Synonyms

SCMH1; sex comb on midleg homolog 1 (Drosophila); polycomb protein SCMH1; Scml3;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SCMH1-28619TH	Recombinant Human SCMH1, His-tagged	E.coli	His		Inquiry
Human	SCMH1-2534H	Recombinant Human SCMH1, GST-tagged	E.coli	GST	C-term-300aa	$319 / 25ug
Human	SCMH1-2033HCL	Recombinant Human SCMH1 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	SCMH1-14750M	Recombinant Mouse SCMH1 Protein	Mammalian Cell	His		Inquiry
Mouse	SCMH1-7935M-B	Recombinant Mouse SCMH1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	SCMH1-7935M	Recombinant Mouse SCMH1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	SCMH1-5587Z	Recombinant Zebrafish SCMH1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SCMH1 Related Articles

SCMH1 involved in several pathways and played different roles in them. We selected most pathways SCMH1 participated on our site, such as Cellular Senescence, Cellular responses to stress, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCMH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cellular Senescence	TINF2;E2F2;CDKN2A;MINK1;CABIN1;CDK4;H3F3B.1;HIST4H4;CEBPB
Cellular responses to stress	WDR45L;ATG101;GABARAP;PRDX2;PHC3;HIST1H1B;DPF1;EED;KIAA1967
Metabolism of proteins	CCDC59;LMAN2;ARL2;VBP1;IGFBP4;ADAMTS1;MUC21;CPB1;DMBT1
Oxidative Stress Induced Senescence	SUZ12A;MINK1;EED;CBX8;TNIK;CBX8A;SCMH1;BMI1A;PHC3
Post-translational protein modification	MLEC;TMED10;ADAMTS5;MGAT4B;NAPB;ST8SIA3;RING1;ADAMTSL5;ST6GAL2B
SUMO E3 ligases SUMOylate target proteins	NSMCE1;RNF2;EID3;SMC5;RING1;CBX4;PHC3;PHC1;SCMH1
SUMOylation	SMC6;RNF2;SENP1;NSMCE4A;PHC2;SAE1;CBX8;SMC5;NSMCE1
SUMOylation of DNA damage response and repair proteins	PHC1;PHC3;SMC6;NSMCE2;SMC5;SCMH1;EID3;RNF2;CBX8

SCMH1 has several biochemical functions, for example, DNA binding, protein binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SCMH1 itself. We selected most functions SCMH1 had, and list some proteins which have the same functions with SCMH1. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	NKX2-3;TBX10;SP6;HMX4;DLX2B;ESRRA;HIST1H2BD;HIST1H4K;NR1D4B
protein binding	FZD2;Acr;NDUFS2;ARHGAP17;ACTB;YIPF4;FAM40A;PIP5K1B;PTCH1
transcription factor activity, sequence-specific DNA binding	SRF;ZFP583;HOXC8A;FOXF2A;DMBX1;RFXANK;PURBB;NFKB1;PITX2

SCMH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCMH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SCMH1.

MAGEA12; UBQLN1; UBQLN1; LYPLA2; TMEM11; HK1; TOB1; GRINL1A; PHC2; UBQLN4; MOB4; Bmi1; Cbx2

Takada, Y; Isono, KI; et al. Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes. DEVELOPMENT 134:579-590(2007).

Sathyamurthy, A; Allen, MD; et al. Crystal structure of the malignant brain tumor (MBT) repeats in Sex Comb on Midleg-like 2 (SCML2). JOURNAL OF BIOLOGICAL CHEMISTRY 278:46968-46973(2003).