SEC61B Protein, Sec61 beta subunit


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Official Full Name Sec61 beta subunit
Background The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.
Synonyms SEC61B; Sec61 beta subunit; protein transport protein Sec61 subunit beta; Protein translocation complex beta; Protein transport protein SEC61 beta subunit; SEC 61B; SEC61 B; Sec61 complex beta subunit; Sec61 complex, beta subunit
    • Species :
    • Chicken
    • Human
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SEC61B-1578HCL Recombinant Human SEC61B cell lysate N/A
    Human SEC61B-2454H Recombinant human SEC61B, His-tagged E.coli His
    Human SEC61B-2567H Recombinant Human SEC61B, His-tagged E.coli His
    Rhesus Macaque SEC61B-4128R Recombinant Rhesus monkey SEC61B Protein, His-tagged Mammalian Cell His
    Chicken SEC61B-5636C Recombinant Chicken SEC61B Mammalian Cell His
    Zebrafish SEC61B-651Z Recombinant Zebrafish SEC61B Mammalian Cell His

    SEC61B involved in several pathways and played different roles in them. We selected most pathways SEC61B participated on our site, such as Adaptive Immune System, Antigen processing-Cross presentation, Class I MHC mediated antigen processing &amp, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEC61B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System Mill2; DYNC1I2; KLC3; PDPK1A; AGO2; RNF111; DYNC1LI2; RAP1GAP2; AMICA1; KIF26A
    Antigen processing-Cross presentation FCGR1B; SEC61B; CTSL2; CD207; CYBB; CTSS; CTSL1; CYBA
    Class I MHC mediated antigen processing &amp UBE2V1; TRIM50; ASB14; CYBB; TRAF7; LRR1; UBE2L6; RNF25; FBXO3; FBXO27
    presentation FBXO3; ASB10; RNF19B; UBE2L6; ASB3; UBE2E3; UBE2J2; LRSAM1; TRIM50; CYBA
    ER-Phagosome pathway SEC61B
    Gene Expression ZNF680; EIF2C3; ZNF311; COX4I1; NR2F1; ZNF317; ZFP36L1; NR0B1; ZNF567; NFIX
    IRE1alpha activates chaperones ASNA1; YIF1A; WIPI1; FKBP14; ADD1; PREB; TPP1; SERP1; C19orf10; SEC63
    Immune System KIF5B; TRIM22; RAPGEF3; SIGLEC10; DUSP3; ASB2; UBE2U; FBXO17; CLEC4A; ATG7
    Metabolism of proteins IGFBP1A; TTR; PMPCB; PROZ; CPB2; SPON1; DHPS; MUC13; CCT7; CBX4

    SEC61B has several biochemical functions, for example, epidermal growth factor binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEC61B itself. We selected most functions SEC61B had, and list some proteins which have the same functions with SEC61B. You can find most of the proteins on our site.

    Function Related Protein
    epidermal growth factor binding SEC61B
    poly(A) RNA binding LYAR; RBM27; RPS10; NOL11; ATP5A1; NOP2; PUM2; EXOSC6; PRR3; PPRC1
    protein binding CCDC108; HIST1H3F; GPI1; EGR2; CDC23; RND2; GTF2A1L; KRTAP3-1; Abcb1b; AGGF1
    ribosome binding NARG1; NAA16; SEC61A1; PPP1R2P9; RICTOR; ABCF1; CPEB1A; ETF1A; EIF2S1B; CPEB1

    SEC61B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEC61B here. Most of them are supplied by our site. Hope this information will be useful for your research of SEC61B.


    Choi, SY; Fogelgren, B; et al. Exocyst Sec10 Is Involved in Basolateral Protein Translation and Translocation in the Endoplasmic Reticulum. NEPHRON EXPERIMENTAL NEPHROLOGY 120:E133-E139(2012).
    Boisrame, A; Chasles, M; et al. Sbh1p, a subunit of the Sec61 translocon, interacts with the chaperone calnexin in the yeast Yarrowia lipolytica. JOURNAL OF CELL SCIENCE 115:4947-4956(2002).

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