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SEC61B

Official Full Name

Sec61 beta subunit
Overview

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.
Synonyms

SEC61B; Sec61 beta subunit; protein transport protein Sec61 subunit beta; Protein translocation complex beta; Protein transport protein SEC61 beta subunit; SEC 61B; SEC61 B; Sec61 complex beta subunit; Sec61 complex, beta subunit;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Canis lupus familiaris (Dog) (Canis familiaris)
Chicken
Homo sapiens (Human)
Human
Rhesus Macaque
Zebrafish

Source

E.coli
E.coli expression system
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SEC61B-2567H	Recombinant Human SEC61B, His-tagged	E.coli	His	1-96aa	$319 / 25ug
Human	SEC61B-2454H	Recombinant human SEC61B, His-tagged	E.coli	His		Inquiry
Human	SEC61B-1578HCL	Recombinant Human SEC61B cell lysate		N/A		Inquiry
Canis lupus familiaris (Dog) (Canis familiaris)	RFL28014CF	Recombinant Full Length Dog Protein Transport Protein Sec61 Subunit Beta(Sec61B) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (2-96)	Inquiry
Homo sapiens (Human)	RFL15566HF	Recombinant Full Length Human Protein Transport Protein Sec61 Subunit Beta(Sec61B) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (2-96)	Inquiry
Rhesus Macaque	SEC61B-4128R	Recombinant Rhesus monkey SEC61B Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	SEC61B-3945R	Recombinant Rhesus Macaque SEC61B Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	SEC61B-3945R-B	Recombinant Rhesus Macaque SEC61B Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	SEC61B-651Z	Recombinant Zebrafish SEC61B	Mammalian Cell	His		Inquiry
Chicken	SEC61B-5636C	Recombinant Chicken SEC61B	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SEC61B Related Articles

SEC61B involved in several pathways and played different roles in them. We selected most pathways SEC61B participated on our site, such as Adaptive Immune System, Antigen processing-Cross presentation, Class I MHC mediated antigen processing &amp, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEC61B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Adaptive Immune System	KIF5B;RNF111;AP2A2;FCGR1B;STIM1B;RAP1GAP2B;ASB13;KIF26A;CD160
Antigen processing-Cross presentation	CYBA;CD207;FCGR1B;CTSL1;CYBB;SEC61B;CTSL2;CTSS
Class I MHC mediated antigen processing &amp	BLMH;CD207;DZIP3;UBE2F;UBE2J2;FBXO3;ATG7;LRSAM1;SPSB4
presentation	RNF4;WSB1;CYBB;TRIM9;ASB2;RNF6;ASB10;UBE2E3;ASB17
ER-Phagosome pathway
Gene Expression	ZNF157;PCBP2;ZNF560;CBX3;SNAPC5;Txn1;GATAD2B;TAF1L;MTF2
IRE1alpha activates chaperones	CXXC1;ADD1;DDX11;HDGF;WIPI1;SERP1;C19orf10;SEC63;HYOU1
Immune System	OSCAR;BTR12;RNF220;ADAR;TAX1BP1;CASP2;TRIM68;RNF135;IRF2
Metabolism of proteins	GZMH;FURINB;B3GNT2A;CNIH;ARSI;NAT8B;NEU3;NOP56;SPCS3

SEC61B has several biochemical functions, for example, epidermal growth factor binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEC61B itself. We selected most functions SEC61B had, and list some proteins which have the same functions with SEC61B. You can find most of the proteins on our site.

Function	Related Protein
epidermal growth factor binding
poly(A) RNA binding	GTL3;AGO3;ZC3H7A;RPL26L1;KHDRBS3;TCOF1;YARS;PLEC;RTN4
protein binding	PTPN14;RELA;RMND1;AVPR1A;OGFR;FBL;SOST;PPP6R2;EPS15
ribosome binding	MTOR;EIF2S1;RPN2;CPEB1;SEC61B;ETF1B;ICT1;IGHMBP2;RPSA

SEC61B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEC61B here. Most of them are supplied by our site. Hope this information will be useful for your research of SEC61B.

BCAP31; SSR1; AURKA; BUB1; MCC; BMPR1A; acpA; CDKN2A; FBXW7; ATP13A2; MLH3; MUTYH; ATG2A; Max

Choi, SY; Fogelgren, B; et al. Exocyst Sec10 Is Involved in Basolateral Protein Translation and Translocation in the Endoplasmic Reticulum. NEPHRON EXPERIMENTAL NEPHROLOGY 120:E133-E139(2012).

Boisrame, A; Chasles, M; et al. Sbh1p, a subunit of the Sec61 translocon, interacts with the chaperone calnexin in the yeast Yarrowia lipolytica. JOURNAL OF CELL SCIENCE 115:4947-4956(2002).