SH3RF1 Protein, SH3 domain containing ring finger 1


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Official Full Name SH3 domain containing ring finger 1
Background This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.
Synonyms SH3RF1; SH3 domain containing ring finger 1; SH3 multiple domains 2 , SH3MD2; E3 ubiquitin-protein ligase SH3RF1; KIAA1494; plenty of SH3 domains; POSH; RNF142; FLJ21602; Plenty of SH3s; Ring finger protein 142; RNF 142; SH3 domain containing RING finger protein 1; SH3 multiple domains 2; OTTHUMP00000219547; SH3 multiple domains protein 2; SH3 domain-containing RING finger protein 1; putative E3 ubiquitin-protein ligase SH3RF; SH3MD2
    • Species :
    • Human
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SH3RF1-1864HCL Recombinant Human SH3RF1 293 Cell Lysate HEK293 N/A
    Human SH3RF1-2652H Recombinant Human SH3RF1, GST-tagged E.coli GST
    Rat SH3RF1-5382R Recombinant Rat SH3RF1 Protein Mammalian Cell His
    Zebrafish SH3RF1-3932Z Recombinant Zebrafish SH3RF1 Mammalian Cell His
    Zebrafish SH3RF1-4417Z Recombinant Zebrafish SH3RF1 Mammalian Cell His

    SH3RF1 involved in several pathways and played different roles in them. We selected most pathways SH3RF1 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SH3RF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System DYNC1LI2; RAP1GAP2B; MGC174152; ASB11; TRIM63; KIF2C; RAP1GAP2; RNF41; ASB17; NRG3
    Antigen processing: Ubiquitination &amp TPP2; WSB1; ASB11; RBCK1; UBE2L6; TRIM69; ASB3; ASB7; UBR2; LTN1
    Proteasome degradation WSB1; TRIM50; WWP1; RNF14; UBE2E3; RNF123; UBR1; ATG7; UBE2L6; ASB9
    Class I MHC mediated antigen processing &amp ASB3; ARIH2; FBXO3; B2ML; TRIM63; VPRBP; RNF144B; ASB18; RNF182; GAN
    presentation TRIM63; ASB17; MKRN1; ATG7; UBE2J2; LRSAM1; FBXO44; UBE2U; CD207; RNF34
    G13 Signaling Pathway MYL1; SH3RF1; RHPN2; ARHGEF1A; MYBPH; GNA13; RTKN; TNK2; DIAPH1; CIT
    Immune System AGER; ICAM4; Siglece; CSHL1; TRIM14; CISH; SIGIRR; DEFA6; POLR3G; HBL3

    SH3RF1 has several biochemical functions, for example, ligase activity, protein binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SH3RF1 itself. We selected most functions SH3RF1 had, and list some proteins which have the same functions with SH3RF1. You can find most of the proteins on our site.

    Function Related Protein
    ligase activity MARCH8; TRIM41; TRIM6; TTLL5; BIRC2; G2E3; RLIM; UBE1Y1; MARCH9; TRIM62
    protein binding KRTAP2-3; GALT; KISS1; SNX15; KAT6B; Ar; LCE1B; CCNT1; GSTA4; ELK4
    zinc ion binding MMP13A; KDM4C; NR4A3; LHX1; ADAMTS15; DBF4B; RBM4B; ADAM23; DRL; MUL1

    SH3RF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SH3RF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SH3RF1.


    Kim, TW; Kang, YK; et al. SH3RF2 functions as an oncogene by mediating PAK4 protein stability. CARCINOGENESIS 35:624-634(2014).
    Karkkainen, S; van der Linden, M; et al. POSH2 is a RING finger E3 ligase with Rac1 binding activity through a partial CRIB domain. FEBS LETTERS 584:3867-3872(2010).

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