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SHB

Official Full Name

Src homology 2 domain containing adaptor protein B
Overview

SH2 domain-containing adapter protein B is a protein that in humans is encoded by the SHB gene.
Synonyms

SHB; Src homology 2 domain containing adaptor protein B; SHB (Src homology 2 domain containing) adaptor protein B , SHB adaptor protein (a Src homology 2 protein); SH2 domain-containing adapter protein B; SHB adaptor protein (a Src homology 2 protein); S;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
His|T7
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SHB-290H	Recombinant Human SHB Protein, His-tagged	E.coli	His		Inquiry
Human	SHB-1948H	Recombinant Human SHB protein, His & T7-tagged	E.coli	His/T7	Ala252~Arg507 (Accession # Q15464)	Inquiry
Human	SHB-6281H	Recombinant Human SHB Protein (Ala252-Arg507), N-His tagged	E.coli	N-His	Ala252-Arg507	Inquiry
Mouse	SHB-15088M	Recombinant Mouse SHB Protein	Mammalian Cell	His		Inquiry
Mouse	SHB-8139M	Recombinant Mouse SHB Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	SHB-8139M-B	Recombinant Mouse SHB Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Shb-1949M	Recombinant Mouse Shb protein, His & T7-tagged	E.coli	His/T7	Ser248~Leu484 (Accession # Q6PD21)	Inquiry

SHB involved in several pathways and played different roles in them. We selected most pathways SHB participated on our site, such as Axon guidance, Developmental Biology, EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with SHB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Axon guidance	ACTR2;SDCBP;DOCK1;MET;EFNA4;DPYSL5A;EPHA6;ITSN1;EPHB3A
Developmental Biology	EFNA4;CDK8;EPHB3A;CDK19;DPYSL4;GFRA2;RASGRP1;NR6A1;HIF3A
EPH-Ephrin signaling	KALRN;EFNA2;EFNA2A;ARPC2;ACTR2;EFNA1B;CLTC;EFNB3B;ARPC5
EPHA-mediated growth cone collapse	EPHA2A;MYL9;EPHA2;SHB;MYL12B;EPHA10;EFNA4;EPHA4A;KDR
IL-2 Signaling Pathway	CISH;SHB;ITM2BA;CD53;NMI
Signal Transduction	OPN4B;FGFBP1;OXER1;TLE4;ZFPM2B;ARHGAP15;RBP3;STRA6;PLEKHG2
Signaling by VEGF	AXL;NRP2B;JUPA;DSCAMA;NRP2;SHB;NRP2A
T Cell Receptor Signaling Pathway	SLA1;RELA;EVLB;IKBKG;PIK3CA;CD8A;PAK6;MUC1;PAK2

SHB has several biochemical functions, for example, SH3/SH2 adaptor activity, glycoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHB itself. We selected most functions SHB had, and list some proteins which have the same functions with SHB. You can find most of the proteins on our site.

Function	Related Protein
SH3/SH2 adaptor activity	IRS4;ARHGAP1;NCK1;SOCS2;GRB10;SLA2;CD28;ITSN2;PAG1
glycoprotein binding	TFRC;SDC1;LCK;F7;CSNK1D;FBXO27;SERPINA1D;BBC3;VIM

SHB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHB here. Most of them are supplied by our site. Hope this information will be useful for your research of SHB.

Pdgfra; FGFR1

Sato, S; Kamada, H; et al. Identification of the Cancer Cell Proliferation and Survival Functions of proHB-EGF by Using an Anti-HB-EGF Antibody. PLOS ONE 8:-(2013).

Tsuji, I; Sato, S; et al. Characterization of a variety of neutralizing anti-heparin-binding epidermal growth factor-like growth factor monoclonal antibodies by different immunization methods. MABS 4:732-739(2012).

Intracellular Signaling Molecules in Angiogenesis

Src Kinases