ski
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  • Official Full Name
  • v-ski avian sarcoma viral oncogene homolog
  • Background
  • This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009]
  • Synonyms
  • SKI; v-ski avian sarcoma viral oncogene homolog; SGS; SKV; ski oncogene; ski oncoprotein; proto-oncogene c-Ski;
Cat.#:SKI-3376CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SKI
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Cat.#:SKI-1815HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SKI 293 Cell Lysate
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Involved Pathway

SKI involved in several pathways and played different roles in them. We selected most pathways SKI participated on our site, such as BMP receptor signaling, C-MYB transcription factor network, Downregulation of SMAD2/3:SMAD4 transcriptional activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with SKI were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
BMP receptor signaling
RGMA; SKI; CTDSPL; HFE2; RGMB; FST; CALML4; CTDSP2; SOSTDC1; NOG
C-MYB transcription factor network
MYF6; CREBBP; CBX4; YEATS4; MYC; COL1A2; MYOD1; PIAS3; TOM1; PTCRA
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SKIA; SMAD3B; USP9; SKI; RNF111; USP9X; SKILB; PARP1; SKIB; TRIM33
Gene Expression
SAP30L; HNRNPL2; NR2F6; ZNF223; NT5C3B; TDRD1; HENMT1; PAIP1; ZFP473; ZNF786
Generic Transcription Pathway
COX18; JUNB; ZNF222; ZNF227; ZNF45; GPR19; ZNF791; ZNF354A; ZNF620; NR5A1
Hedgehog Signaling Pathway
IHH; CSNK1G3; PRKACAA; PRKACB; BMP2B; GSK3B; WNT3A; WNT9B; PTCH1; SKIA
Regulation of nuclear SMAD2/3 signaling
NKX2; FOXH1; CBFB; MYOD1; GSC; SKI; SNIP1; CITED1
Signal Transduction
ARHGEF25; TMED5; IFT172; SDR16C5; FAM123B; LGR4; WDR19; INSL3; DSCAMA; NMB

Protein Function

SKI has several biochemical functions, for example, SMAD binding, chromatin binding, histone deacetylase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SKI itself. We selected most functions SKI had, and list some proteins which have the same functions with SKI. You can find most of the proteins on our site.
Function
Related Protein
Function SMAD binding
Related Protein SKIA; CTNNB1; SMAD2; FOXH1; USP15; SKOR1; RNF111; SKI; COL5A2; DAB2
Function chromatin binding
Related Protein ING5; TADA2B; NFATC2; OST4; PHF21B; MAZ; CREBBP; NKAP; GM606; CEBPB
Function histone deacetylase inhibitor activity
Related Protein SKI; UCN
Function protein binding
Related Protein OTUB2; LAX1; TPSAB1; PDHB; MESDC1; SOCS3; RTP3; SVIL; RFESD; IGF2BP1
Function protein domain specific binding
Related Protein NF2; BHLHE40; VPS4A; GABRR2; SP100; RAP2B; STX1B; IPCEF1; HIST1H4C; TFDP1
Function protein kinase binding
Related Protein DAXX; SPAG16; FGR; CAMK2N1A; HCLS1; GRB2; KIF14; PTK2; CDK5RAP3; ADAM10
Function repressing transcription factor binding
Related Protein CTNNB1; HDAC1; HHEX; TCF3; NFYB; GMNN; RUNX2; MYC; HDAC9; DDX20
Function transcription corepressor activity
Related Protein NR2F2; FEV; ZFPM2; ZFPM1; BATF3; SUFU; CCAR1; YAF2; WTIP; PSMC3
Function ubiquitin protein ligase binding
Related Protein CUL5A; POLR2A; UBE2T; HDAC6; CASP10; H2-AB1; PA2G4; CDC34; TMEM173; UBE2R2
Function zinc ion binding
Related Protein RNF151; PPARD; BFAR; QPCT; PIAS1; TRAF1; RNF152; NR3C1; SHANK3; ZMAT2

Interacting Protein

SKI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SKI here. Most of them are supplied by our site. Hope this information will be useful for your research of SKI.
SMAD3; SMAD4

SKI Related Articles

Verbeke, SLJ; de Jong, D; et al. Array CGH Analysis Identifies Two Distinct Subgroups of Primary Angiosarcoma of Bone. GENES CHROMOSOMES & CANCER 54:72-81(2015).
Mei, Y; Thompson, MD; et al. Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase C674 promotes ischemia- and hypoxia-induced angiogenesis via coordinated endothelial cell and macrophage function. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 76:275-282(2014).