ski
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  • Official Full Name
  • v-ski avian sarcoma viral oncogene homolog
  • Background
  • This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009]
  • Synonyms
  • SKI; v-ski avian sarcoma viral oncogene homolog; SGS; SKV; ski oncogene; ski oncoprotein; proto-oncogene c-Ski;
Cat.#:SKI-3376CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SKI
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Cat.#:SKI-1815HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SKI 293 Cell Lysate
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Involved Pathway

SKI involved in several pathways and played different roles in them. We selected most pathways SKI participated on our site, such as BMP receptor signaling, C-MYB transcription factor network, Downregulation of SMAD2/3:SMAD4 transcriptional activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with SKI were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
BMP receptor signaling
CTDSPL; NOG; CTDSP1; RGMA; CALML4; RGMB; FST; CTDSP2; AHSG; SOSTDC1
C-MYB transcription factor network
CBX4; CDKN1B; PIAS3; MYOD1; CEBPB; MYC; LECT2; SMARCA2; YEATS4; CREBBP
Downregulation of SMAD2/3:SMAD4 transcriptional activity
RNF111; PARP1; USP9X; TRIM33; SKILB; SKIB; SKIA; USP9; SMAD3B; SKI
Gene Expression
MED23; ZNF100; ZNF71; ZMAT5; ZNF224; LAMTOR1; MED13A; ESRRGA; ARHGEF38; LRPPRC
Generic Transcription Pathway
ZNF184; ZNF550; ZNF691; ZNF234; NR2F1; ZNF200; ZNF285A; RORAA; NR2F1B; SESN3
Hedgehog Signaling Pathway
WNT7A; ZIC2B; WNT11R; CSNK1G1; STK36; PRKACAA; WNT3A; SKI; BMP2B; BMP2
Regulation of nuclear SMAD2/3 signaling
GSC; NKX2; CITED1; MYOD1; SKI; SNIP1; CBFB; FOXH1
Signal Transduction
NOXO1A; BBS13; PTH2; LINGO1B; PROK1; MKL1B; TAS2R16; CRABP2; USP9; ARHGEF16

Protein Function

SKI has several biochemical functions, for example, SMAD binding, chromatin binding, histone deacetylase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SKI itself. We selected most functions SKI had, and list some proteins which have the same functions with SKI. You can find most of the proteins on our site.
Function
Related Protein
Function SMAD binding
Related Protein COL1A2; SKOR1A; SKOR2; BMPR1B; SKILB; SKIB; YY1; SKI; EID2; TGFBRAP1
Function chromatin binding
Related Protein TFAM; ATOH1A; ASH1L; MED1; TCF3; SP3; PRKCB; KAT2A; HMGB3A; FOXC1A
Function histone deacetylase inhibitor activity
Related Protein UCN; SKI
Function protein binding
Related Protein DSN1; FBXL15; NUSAP1; METTL21C; RYR1; TSHR; TPT1; MYH7B; KCNIP3; CEP350
Function protein domain specific binding
Related Protein PRKCZ; CASP2; PHRF1; IPCEF1; HIST1H4A; AIDA; ARFIP2; TJP2; YWHAQA; ZFP521
Function protein kinase binding
Related Protein SKAP1; NBEA; KIF11; GYS1; CACNB4; AXIN1; PRKAG3; MAP3K12; CDC25A; FAM83E
Function repressing transcription factor binding
Related Protein CTBP1; MAGEA2B; HDAC7A; TBP; GMNN; HDAC7; RELA; SRI; PARK7; MAGEA2
Function transcription corepressor activity
Related Protein NR0B1; ID4; TOB1; ASXL1; PSMC3; BHLHE40; ALX1; SKIL; RELB; CBFA2T2
Function ubiquitin protein ligase binding
Related Protein PML; MAP1LC3B; PRDX6; TCP1; BLZF1; TOLLIP; UBE2V1; UBE2NA; UBXN1; USP2
Function zinc ion binding
Related Protein LDB3; TRIM35-20; ZFP326; MORC2A; BRD1B; TRIM41; TRIM109; PCGF5A; DZIP3; ESR2

Interacting Protein

SKI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SKI here. Most of them are supplied by our site. Hope this information will be useful for your research of SKI.
SMAD3; SMAD4

SKI Related Articles

Verbeke, SLJ; de Jong, D; et al. Array CGH Analysis Identifies Two Distinct Subgroups of Primary Angiosarcoma of Bone. GENES CHROMOSOMES & CANCER 54:72-81(2015).
Mei, Y; Thompson, MD; et al. Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase C674 promotes ischemia- and hypoxia-induced angiogenesis via coordinated endothelial cell and macrophage function. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 76:275-282(2014).