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Official Full Name v-ski avian sarcoma viral oncogene homolog
Background This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009]
Synonyms SKI; v-ski avian sarcoma viral oncogene homolog; SGS; SKV; ski oncogene; ski oncoprotein; proto-oncogene c-Ski;
    • Species :
    • Chicken
    • Human
    • Source :
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SKI-1815HCL Recombinant Human SKI 293 Cell Lysate HEK293 N/A
    Chicken SKI-3376C Recombinant Chicken SKI Mammalian Cell His

    SKI involved in several pathways and played different roles in them. We selected most pathways SKI participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with SKI were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    BMP receptor signaling NOG; FST; SKI; CHRDL1; CTDSPL; CALML4; SOSTDC1; CTDSP1; HFE2; GREM1
    C-MYB transcription factor network GATA1; MYC; CBX4; PRTN3; LECT2; CLTA; PPID; CREBBP; TOM1; ADA
    Downregulation of SMAD2/3:SMAD4 transcriptional activity SKIA; SKI; RNF111; TRIM33; USP9; SKIB; PARP1; SKILB; SMAD3B; USP9X
    Gene Expression HNRNPA2B1; ARHGEF38; PEAK1; DCP1B; AIMP2; ZNF643; PDCD7; RRAGB; USP9X; HELZ2
    Generic Transcription Pathway VDRB; ZNF287; ZNF434; COX8A; ZNF19; ZNF333; ZFP30; ZNF773; ZNF398; COX6B1
    Hedgehog Signaling Pathway LRP2A; ZIC2A; GLI3; PRKACG; CSNK1G2B; SMO; GSK3AA; WNT7A; CSNK1DB; GLI2A
    Regulation of nuclear SMAD2/3 signaling SNIP1; SKI; NKX2; FOXH1; GSC; CITED1; CBFB; MYOD1
    Signal Transduction ADM2A; OPN4.1; RPE65A; OPN5; RTN4A; LGR5; BCL9L; CRABP2; NTS; RHOUA

    SKI has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by SKI itself. We selected most functions SKI had, and list some proteins which have the same functions with SKI. You can find most of the proteins on our site.

    Function Related Protein
    SMAD binding MEF2A; TCF12; YY1; FKBP1A; FOXH1; STUB1; EP300; SMAD2; COL3A1; PML
    chromatin binding CRX; NAP1L2; UBTF; CHD7; MBD5; ANKRD2; GPR30; RERE; LDB2A; AIRE
    histone deacetylase inhibitor activity UCN; SKI
    protein binding NISCH; FGF12; BOC; P4HB; MGP; ATP1B2; SH2D1A; TBKBP1; CST2; ATP6V1B2
    protein domain specific binding CA; ARRB2; PKD1; TRIM11; EHD2; CALM1; NR0B2; GABRR2; PHRF1; KCTD13
    protein kinase binding IRS2; GPRC5B; PPP1R12B; RPS19; CD3E; HDAC4; FGFR1OP; CADPS; MAG; ACTA2
    repressing transcription factor binding RELA; SRI; HDAC9; HHEX; HDAC7A; SKI; EIF4E; HDAC1; MAGEA2B; ARNTL
    transcription corepressor activity WTIP; SKI; YAF2; E2F8; SRSF2; TSG101; SMARCA4; HDAC9; RYBP; JUNB
    ubiquitin protein ligase binding USP2; UBE2J2; SMAD7; NPLOC4; LC3; CUL3B; ERLIN2; UBE2Z; SPOP; CUL1
    zinc ion binding KLF7; RBM4.2; ADAMTS16; TLL2; DHX58; SETDB1; PPARA; LIG3; RNF141; RNF31

    SKI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SKI here. Most of them are supplied by our site. Hope this information will be useful for your research of SKI.

    SMAD3; SMAD4

    Verbeke, SLJ; de Jong, D; et al. Array CGH Analysis Identifies Two Distinct Subgroups of Primary Angiosarcoma of Bone. GENES CHROMOSOMES & CANCER 54:72-81(2015).
    Mei, Y; Thompson, MD; et al. Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase C674 promotes ischemia- and hypoxia-induced angiogenesis via coordinated endothelial cell and macrophage function. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 76:275-282(2014).

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