ski
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  • Official Full Name
  • v-ski avian sarcoma viral oncogene homolog
  • Background
  • This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009]
  • Synonyms
  • SKI; v-ski avian sarcoma viral oncogene homolog; SGS; SKV; ski oncogene; ski oncoprotein; proto-oncogene c-Ski;
Cat.#:SKI-3376CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SKI
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Cat.#:SKI-1815HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SKI 293 Cell Lysate
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Involved Pathway

SKI involved in several pathways and played different roles in them. We selected most pathways SKI participated on our site, such as BMP receptor signaling, C-MYB transcription factor network, Downregulation of SMAD2/3:SMAD4 transcriptional activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with SKI were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
BMP receptor signaling
CTDSP1; FST; RGMA; HFE2; CTDSPL; CALML4; SOSTDC1; AHSG; SKI; NOG
C-MYB transcription factor network
ADA; MYC; PRTN3; CDK6; LECT2; GATA1; SMARCA2; CLTA; CREBBP; CDKN1B
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SKI; PARP1; RNF111; TRIM33; SKILB; SKIA; SKIB; SMAD3B; USP9; USP9X
Gene Expression
DGCR8; MANEA; SF3B2; TPRKB; ZNF621; EIF4H; ZNF786; ZNF562; GTF3C5; CCNT2B
Generic Transcription Pathway
ZNF71; ZNF718; ZNF706; ZNF19; ZNF10; NR2E1; ZNF433; ZNF302; C7orf59; MED7
Hedgehog Signaling Pathway
GSK3AA; WNT5A; SMO; SKI; WNT9A; STK36; IHH; DYRK1A; HHIP; IHHB
Regulation of nuclear SMAD2/3 signaling
SNIP1; CITED1; NKX2; FOXH1; MYOD1; SKI; CBFB; GSC
Signal Transduction
PROKR1A; AMOTL2; ARHGEF1B; EVC; AATF; PYY; FOXH1; DZIP1; APOM; CRABP1

Protein Function

SKI has several biochemical functions, for example, SMAD binding, chromatin binding, histone deacetylase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SKI itself. We selected most functions SKI had, and list some proteins which have the same functions with SKI. You can find most of the proteins on our site.
Function
Related Protein
Function SMAD binding
Related Protein FLNA; FKBP1A; PURA; COL1A2; USP15; SKOR1B; MAGI2; MEF2A; FOXH1; BMPR1B
Function chromatin binding
Related Protein LMO2; CBX1; KAT2A; TBL1Y; HDGF2; DNMT3B; HMGXB4; MED12; SSRP1A; GATA4
Function histone deacetylase inhibitor activity
Related Protein SKI; UCN
Function protein binding
Related Protein WDFY2; NR0B2; PPP3CC; TNFSF13B; CCDC13; TNFRSF6B; CORO6; C1orf216; PICK1; SMNDC1
Function protein domain specific binding
Related Protein CTBP1; ACSL3; YWHAE; HAND2; MYO7A; GSN; HMGB2; STRN4; COX4I2; ATN1
Function protein kinase binding
Related Protein CADPS; TRIB3; PGAM1; THY1; KIF11; ATP1A1; LIPE; PTPN1; SHC4; RAD9
Function repressing transcription factor binding
Related Protein KAT5; SRI; EIF4E; CTBP1; HDAC5; NFYB; SKI; HDAC7; MAGEA2; HMGB1
Function transcription corepressor activity
Related Protein IRF2BP2; NAB2; HSF4; JUB; MECP2; TMEM38A; TRIB3; TBL1XR1A; SETD8; SSX2
Function ubiquitin protein ligase binding
Related Protein ATXN3; FBXW7; LRPPRC; HSPA1L; PINK1; ABI2; TRAF5; CXCR4; PRR5L; CCDC50
Function zinc ion binding
Related Protein SETDB1B; RNF34B; ZDHHC3; MARCH4; ADAMTS8; TRAF5; CECR1; TRIM50; CA4; IDE

Interacting Protein

SKI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SKI here. Most of them are supplied by our site. Hope this information will be useful for your research of SKI.
SMAD3; SMAD4

SKI Related Articles

Verbeke, SLJ; de Jong, D; et al. Array CGH Analysis Identifies Two Distinct Subgroups of Primary Angiosarcoma of Bone. GENES CHROMOSOMES & CANCER 54:72-81(2015).
Mei, Y; Thompson, MD; et al. Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase C674 promotes ischemia- and hypoxia-induced angiogenesis via coordinated endothelial cell and macrophage function. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 76:275-282(2014).