skil
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  • Official Full Name
  • SKI-like oncogene
  • Background
  • The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene.
  • Synonyms
  • SKIL; SKI-like oncogene; ski-like protein; SNO; SnoA; SnoN; ski-related oncogene snoN; SnoI
Cat.#:SKIL-2688HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SKIL, His-tagged
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Cat.#:SKIL-27723THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human SKIL
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Cat.#:SKIL-27724THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human SKIL
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Cat.#:SKIL-6729CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SKIL
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Cat.#:SKIL-1814HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human SKIL 293 Cell Lysate
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Involved Pathway

SKIL involved in several pathways and played different roles in them. We selected most pathways SKIL participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with SKIL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Signaling pathways regulating pluripotency of stem cells
ONECUT1; PIK3CA; BMI1; WNT11; IL6ST; WNT2; AKT2; AKT1; ISL1; SMAD9

Protein Function

SKIL has several biochemical functions, for example, NOT DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SKIL itself. We selected most functions SKIL had, and list some proteins which have the same functions with SKIL. You can find most of the proteins on our site.
Function
Related Protein
Function NOT DNA binding
Related Protein MBD5; HIPK2; NFIB; XRCC4; TINF2; SKIL
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein ZNF680; SREBF1; TTC6; RFX3; SREBF2; MESP1; NR4A3; ARID3B; ZSCAN21; IRF1
Function SMAD binding
Related Protein TGFBR2; ACVRL1; MAGI2; STUB1; BMP2; USP15; PURB; TGFBR1; TGFBRAP1; COL3A1
Function chromatin binding
Related Protein PCGF2; DLX3; CAMTA2; HCFC1; CREB3L1; TDRD3; EWSR1A; CDCA5; WDHD1; NCOA2
Function protein binding
Related Protein DZIP1L; HELLS; SERPINB9; TRPM6; FAM107A; MC5R; EXOSC5; PKM; HADHB; PLAT
Function protein complex binding
Related Protein CAV3; PPP1R9B; CDKN1B; RAD18; RAP1B; ATM; PTPRF; VHLL; RELA; FADD
Function protein domain specific binding
Related Protein HIST1H4H; PHRF1; ETV6; FOXA1; STX1B; YWHABB; ARL1; CA; PLAUR; HIST1H4F
Function transcription corepressor activity
Related Protein HDAC4; HDAC5; DNMT3B; ZHX2; SNW1; CSDA; THRB; SOD3; DRAP1; HOXC6
Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein PYDC3; ZFP536; IFI16; MXD1; BCL11AA; EN1; ZBTB20; ZFP746; PROX1B; HELT

Interacting Protein

SKIL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SKIL here. Most of them are supplied by our site. Hope this information will be useful for your research of SKIL.
OIP5; STK16; AES; VPS28; NXF3; DRG1; Ncor1