• Official Full Name
  • solute carrier family 22, member 18
  • Background
  • This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Two alternatively spliced transcript variants encoding the same protein have been described.
  • Synonyms
  • SLC22A18; solute carrier family 22, member 18; BWSCR1A, IMPT1, ORCTL2, SLC22A1L, solute carrier family 22 (organic cation transporter), member 1 like; solute carrier family 22 member 18; BWR1A; ITM; TSSC5; IMPT1; OTTMUSP00000030800; Beckwith Wiedemann syndrome chromosomal region 1 candidate gene A protein; BWSCR1A; DKFZp667A184; Efflux transporter like protein; HET; Imprinted multi membrane spanning polyspecific transporter related protein 1; MGC94186; ORCTL 2; ORCTL2; Organic cation transporter like protein 2; OTTMUSP00000030799; p45 Beckwith Wiedemann region 1 A; p45 BWR1A; SLC22A1L; Solute carrier family 22 member 1 like; TSSC5v; Tumor suppressing STF cDNA 5 protein; Tumor suppressing subchromosomal transferable fragment candidate gene 5 protein; ORCTL-2; OTTHUMP00000011731; OTTHUMP00000011732; OTTHUMP00000011733; OTTHUMP00000012598; efflux transporter-like protein; p45 Beckwith-Wiedemann region 1A; organic cation transporter-like 2; p45-Beckwith-Wiedemann region 1 A; tumor-suppressing STF cDNA 5 protein; organic cation transporter-like protein 2; Beckwith-Wiedemann syndrome chromosome region 1, candidate A; beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein; imprinted multi-membrane spanning polyspecific transporter-related protein 1; imprinted multi-membrane-spanning polyspecific transporter-related protein 1; tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein; p45-BWR1A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SLC22A18, GST-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SLC22A18 Protein
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SLC22A18 Protein
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SLC22A18
Source (Host):Species:Human
Product nameRecombinant Human SLC22A18 cell lysate

Involved Pathway

SLC22A18 involved in several pathways and played different roles in them. We selected most pathways SLC22A18 participated on our site, such as Organic cation transport, Organic cation/anion/zwitterion transport, SLC-mediated transmembrane transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC22A18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Organic cation transport
SLC22A15; SLC22A16; SLC22A18
Organic cation/anion/zwitterion transport
SLC22A18; SLC22A7A; SLC22A15; SLC22A12; SLC22A7B.1; SLC22A6; SLC22A7; SLC22A16
SLC-mediated transmembrane transport
SLC35D2; SLC47A1; SLC24A5; SLC30A8; SLC15A3; LCN9; SLC24A6; LCN12; SLC22A7A; SLC12A7
Transmembrane transport of small molecules
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
SLC5A4; SLC2A15A; SLC6A9; SLC13A5A; SLC6A6; SLC13A4; RHCG; SLC22A7B.1; SLC2A6; SLC16A7

Protein Function

SLC22A18 has several biochemical functions, for example, drug transmembrane transporter activity, symporter activity, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC22A18 itself. We selected most functions SLC22A18 had, and list some proteins which have the same functions with SLC22A18. You can find most of the proteins on our site.
Related Protein
Function drug transmembrane transporter activity
Related Protein SLC18A3A; SLC18A3B; SLC22A5; ABCG2A; SLCO1B2; SLC18A1; SLC22A18; EBP; SLC17A3; SLC47A2
Function symporter activity
Related Protein SLC46A2; SLC20A1A; SLC38A1; PPP1R42; SLC25A22; MFSD2AB; SLC34A3; SLC1A8B; SLC16A12B; SLC24A2
Function ubiquitin protein ligase binding
Related Protein FAF2; UBE2J2; CUL3B; BRCA1; RELA; CD40; CASP8; ERBB2; CASP10; ACVR1B

SLC22A18 Related Articles

Zhang, BC; Liu, T; et al. microRNA-137 functions as a tumor suppressor in human non-small cell lung cancer by targeting SLC22A18. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 74:111-118(2015).
Chu, SH; Zhou, ZM; et al. In vitro and in vivo radiosensitization of human glioma U251 cells induced by upregulated expression of SLC22A18. CANCER GENE THERAPY 21:103-109(2014).