slc26a3
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  • Official Full Name
  • solute carrier family 26, member 3
  • Background
  • The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea.
  • Synonyms
  • SLC26A3; solute carrier family 26, member 3; CLD, congenital chloride diarrhea , DRA; chloride anion exchanger; down-regulated in adenoma protein; CLD; DRA
Cat.#:SLC26A3-2733HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SLC26A3, GST-tagged
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Cat.#:SLC26A3-31415THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human SLC26A3
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Cat.#:SLC26A3-15341MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SLC26A3 Protein
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Cat.#:SLC26A3-5484RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SLC26A3 Protein
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Cat.#:SLC26A3-4310CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SLC26A3
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Cat.#:SLC26A3-1753HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human SLC26A3 293 Cell Lysate
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Involved Pathway

SLC26A3 involved in several pathways and played different roles in them. We selected most pathways SLC26A3 participated on our site, such as Mineral absorption, Multifunctional anion exchangers, Pancreatic secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC26A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Mineral absorption
MT2; SLC26A9; SLC11A1; VDR; FTH1; SLC8A1; FTL; S100G; MT1; ATP7A
Multifunctional anion exchangers
SLC26A6L; SLC26A3.1; SLC26A3; SLC26A2; SLC26A3.2; SLC26A1; SLC26A7
Pancreatic secretion
ATP1B2; ATP1A3; CPA3; RAP1B; ITPR1; SCTR; PLA2G3; RAB8A; CELA2A; CELA2B
SLC-mediated transmembrane transport
SLC16A7; SLC6A6A; SLC5A8; SLC13A5A; SLC30A2; SLC7A3; SLC22A7B.1; SLC6A9; SLC30A8; SLC4A4A
Transmembrane transport of small molecules
GSDMA2; SLC13A5; SLC38A5B; SLC39A6; SLC2A15A; TSC22D3; AQP11; ANO10; TRPM4C; SLC20A2
Transport of inorganic cations/anions and amino acids/oligopeptides
SLC9A5; SLC12A1; SLC38A3A; SLC4A1A; SLC4A2A; SLC9A8; SLC7A6; SLC26A3.2; SLC4A1B; SLC9A9

Protein Function

SLC26A3 has several biochemical functions, for example, anion:anion antiporter activity, bicarbonate transmembrane transporter activity, chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC26A3 itself. We selected most functions SLC26A3 had, and list some proteins which have the same functions with SLC26A3. You can find most of the proteins on our site.
Function
Related Protein
Function anion:anion antiporter activity
Related Protein SLC26A6L; SLC26A3.1; SLC26A3.2; SLC26A1; SLC26A2; SLC4A1B; SLC4A2A; SLC26A9; SLC26A4; SLC26A11
Function bicarbonate transmembrane transporter activity
Related Protein SLC26A1; SLC26A6; SLC26A9; SLC4A1B; SLC4A1; SLC26A2; SLC26A3; SLC26A5; SLC26A11; SLC26A7
Function chloride channel activity
Related Protein FXYD1; CLCNKB; TTYH3B; SLC26A9; CLCA3; SLC26A7; APOL1; GABRR1; GRAP2; CLCA2
Function chloride transmembrane transporter activity
Related Protein SLC26A6; Slc4a2; SLC26A3; SLC4A1; CFTR; SLC26A4; SLC26A1
Function oxalate transmembrane transporter activity
Related Protein SLC26A6; SLC26A11; SLC26A6L; SLC26A4; SLC26A3.2; SLC26A9; SLC26A7; SLC26A1; SLC26A3; SLC26A2
Function protein binding
Related Protein LAMA1; PHF10; RNF13; CMKLR1; TMEM174; AF251705; DIS3L; UBASH3A; COPE; EIF4E
Function secondary active sulfate transmembrane transporter activity
Related Protein SLC26A4; SLC26A3; SLC26A5; SLC26A3.1; SLC26A2; SLC26A9; SLC26A6; SLC13A1; SLC26A11; SLC26A3.2
Function sulfate transmembrane transporter activity
Related Protein SLC26A2; SLC26A7; SLC26A3; SLC26A4; SLC26A1; SLC26A6L; SLC26A6; SLC26A5; SLC26A3.1; SLC26A11
Function transcription cofactor activity
Related Protein ZNF212; PHF21B; LPXN; MED17; ELK4; MED30; MSX2; PRKCBP1L; THRAP3; BTG1
Function transcription factor activity, sequence-specific DNA binding
Related Protein SMAD6A; NEUROD2; BACH2; ZSCAN4F; FLI1; KLF11; BACH1A; EOMES; RORCA; ZNF668
Function transporter activity
Related Protein ABCA9; SEC14L3; MIPB; ATP5G3; TIMM10; HIAT1B; SLC6A18; SLC17A9B; AQP12B; ABCC1

Interacting Protein

SLC26A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC26A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC26A3.
SLC9A3R2