slc4a4
Share
  • Official Full Name
  • solute carrier family 4, sodium bicarbonate cotransporter, member 4
  • Background
  • This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • SLC4A4; solute carrier family 4, sodium bicarbonate cotransporter, member 4; electrogenic sodium bicarbonate cotransporter 1; NBC-like protein; Na+HCO3- cotransporter 4; Na(+)/HCO3(-) cotransporter; sodium bicarbonate cotransporter; solute carrier family
Cat.#:SLC4A4-2775HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SLC4A4, GST-tagged
+Inquiry
Cat.#:SLC4A4-31418THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SLC4A4, His-tagged
+Inquiry
Cat.#:SLC4A4-31419THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SLC4A4, His-tagged
+Inquiry
Cat.#:SLC4A4-505HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SLC4A4 , His-tagged
+Inquiry
Cat.#:SLC4A4-5551RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SLC4A4 Protein
+Inquiry

Involved Pathway

SLC4A4 involved in several pathways and played different roles in them. We selected most pathways SLC4A4 participated on our site, such as Proximal tubule bicarbonate reclamation, Pancreatic secretion, Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC4A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Proximal tubule bicarbonate reclamation
CA4; ATP1B1; ATP1B3; SLC38A3; Car2; SLC4A4; ATP1B2; GLS2; Car4; SLC9A3
Pancreatic secretion
PLCB2; SLC9A1; GNAQ; CELA3B; CELA2B; PLA2G12A; CELA2A; ATP1A2; TPCN2; RAB3D
Bile secretion
ATP1B2; SLC2A1; ADCY7; ABCC3; ATP1B1; NCEH1; ADCY3; SLC51B; SLC10A1; OSTA

Protein Function

SLC4A4 has several biochemical functions, for example, inorganic anion exchanger activity, protein binding, sodium:bicarbonate symporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC4A4 itself. We selected most functions SLC4A4 had, and list some proteins which have the same functions with SLC4A4. You can find most of the proteins on our site.
Function
Related Protein
Function inorganic anion exchanger activity
Related Protein SLC22A9; SLC4A4; SLC22A24; SLC4A4A; SLC22A20; Slc4a2; SLC22A6; SLC4A1A; SLC4A1; SLC22A8
Function protein binding
Related Protein EGLN2; LOC729991; SMC3; ZBED3; UBQLN4; C8orf74; CIR1; SSRP1; RASSF3; MLLT1
Function sodium:bicarbonate symporter activity
Related Protein SLC4A4; SLC4A8; SLC26A3.1; SLC4A4A; SLC26A6L

Interacting Protein

SLC4A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC4A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC4A4.
CA4; SREBF2; glpF

SLC4A4 Related Articles

Jalali, R; Guo, J; et al. NBCe1 (SLC4A4) a potential pH regulator in enamel organ cells during enamel development in the mouse. CELL AND TISSUE RESEARCH 358:433-442(2014).
Gregorio, SF; Carvalho, ESM; et al. Endocrine regulation of carbonate precipitate formation in marine fish intestine by stanniocalcin and PTHrP. JOURNAL OF EXPERIMENTAL BIOLOGY 217:1555-1562(2014).