|Official Full Name||solute carrier family 4, sodium bicarbonate cotransporter, member 4|
|Background||This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene.|
|Synonyms||SLC4A4; solute carrier family 4, sodium bicarbonate cotransporter, member 4; electrogenic sodium bicarbonate cotransporter 1; NBC-like protein; Na+HCO3- cotransporter 4; Na(+)/HCO3(-) cotransporter; sodium bicarbonate cotransporter; solute carrier family|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
SLC4A4 involved in several pathways and played different roles in them. We selected most pathways SLC4A4 participated on our site, such as Proximal tubule bicarbonate reclamation, Pancreatic secretion, Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC4A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Proximal tubule bicarbonate reclamation||SLC25A10; ATP1B1; ATP1A3; FXYD2; Car2; Car4; ATP1A4; GLUD1; SLC38A3; CA2|
|Pancreatic secretion||PLA2G10; ATP1B3; CELA3A; PLCB4; RAP1B; PLA2G12B; CLCA2; PRSS2; ATP1A3; GNAS|
|Bile secretion||ABCB1A; SLC2A1; CYP3A4; ATP1B4; SLCO1A2; FXYD2; ABCC3; NCEH1; SLCO1A4; ABCB11|
SLC4A4 has several biochemical functions, for example, inorganic anion exchanger activity, protein binding, sodium:bicarbonate symporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC4A4 itself. We selected most functions SLC4A4 had, and list some proteins which have the same functions with SLC4A4. You can find most of the proteins on our site.
|inorganic anion exchanger activity||SLC4A4; SLC22A20; SLC22A24; SLC4A3; SLC4A4A; SLC22A6; SLC22A12; SLC22A9; SLC4A11; SLC4A1A|
|protein binding||COX8A; MT1H; MOBKL1A; TBX6; RIBC2; RUNX3; NR1H3; DERL2; GABARAPL1; CALM3|
|sodium:bicarbonate symporter activity||SLC4A4A; SLC4A8; SLC26A6L; SLC4A4; SLC26A3.1|
SLC4A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC4A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC4A4.
CA4; SREBF2; glpF