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Official Full Name solute carrier family 4, sodium bicarbonate cotransporter, member 4
Background This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms SLC4A4; solute carrier family 4, sodium bicarbonate cotransporter, member 4; electrogenic sodium bicarbonate cotransporter 1; NBC-like protein; Na+HCO3- cotransporter 4; Na(+)/HCO3(-) cotransporter; sodium bicarbonate cotransporter; solute carrier family
    • Species :
    • Human
    • Rat
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SLC4A4-2775H Recombinant Human SLC4A4, GST-tagged E.coli GST
    Human SLC4A4-31418TH Recombinant Human SLC4A4, His-tagged E.coli His
    Human SLC4A4-31419TH Recombinant Human SLC4A4, His-tagged E.coli His
    Human SLC4A4-505H Recombinant Human SLC4A4 , His-tagged E.coli His
    Rat SLC4A4-5551R Recombinant Rat SLC4A4 Protein Mammalian Cell His

    SLC4A4 involved in several pathways and played different roles in them. We selected most pathways SLC4A4 participated on our site, such as Proximal tubule bicarbonate reclamation, Pancreatic secretion, Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC4A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Proximal tubule bicarbonate reclamation SLC25A10; ATP1B1; ATP1A3; FXYD2; Car2; Car4; ATP1A4; GLUD1; SLC38A3; CA2
    Pancreatic secretion PLA2G10; ATP1B3; CELA3A; PLCB4; RAP1B; PLA2G12B; CLCA2; PRSS2; ATP1A3; GNAS
    Bile secretion ABCB1A; SLC2A1; CYP3A4; ATP1B4; SLCO1A2; FXYD2; ABCC3; NCEH1; SLCO1A4; ABCB11

    SLC4A4 has several biochemical functions, for example, inorganic anion exchanger activity, protein binding, sodium:bicarbonate symporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC4A4 itself. We selected most functions SLC4A4 had, and list some proteins which have the same functions with SLC4A4. You can find most of the proteins on our site.

    Function Related Protein
    inorganic anion exchanger activity SLC4A4; SLC22A20; SLC22A24; SLC4A3; SLC4A4A; SLC22A6; SLC22A12; SLC22A9; SLC4A11; SLC4A1A
    protein binding COX8A; MT1H; MOBKL1A; TBX6; RIBC2; RUNX3; NR1H3; DERL2; GABARAPL1; CALM3
    sodium:bicarbonate symporter activity SLC4A4A; SLC4A8; SLC26A6L; SLC4A4; SLC26A3.1

    SLC4A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC4A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC4A4.

    CA4; SREBF2; glpF

    Jalali, R; Guo, J; et al. NBCe1 (SLC4A4) a potential pH regulator in enamel organ cells during enamel development in the mouse. CELL AND TISSUE RESEARCH 358:433-442(2014).
    Gregorio, SF; Carvalho, ESM; et al. Endocrine regulation of carbonate precipitate formation in marine fish intestine by stanniocalcin and PTHrP. JOURNAL OF EXPERIMENTAL BIOLOGY 217:1555-1562(2014).

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