snx4
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  • Official Full Name
  • sorting nexin 4
  • Background
  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members.
  • Synonyms
  • SNX4; sorting nexin 4; sorting nexin-4; ATG24B; SNX 4; SNX4_HUMAN; OTTHUMP00000215866
Cat.#:SNX4-2323HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SNX4 Protein, MYC/DDK-tagged
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Cat.#:SNX4-2864HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SNX4, GST-tagged
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Cat.#:SNX4-31429THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SNX4, His-tagged
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Cat.#:SNX4-15735MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SNX4 Protein
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Cat.#:SNX4-2267ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SNX4
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Cat.#:SNX4-1663HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SNX4 cell lysate
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Involved Pathway

SNX4 involved in several pathways and played different roles in them. We selected most pathways SNX4 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Endocytosis
IL2RGB; HSPA6; SH3GL1A; SNX6; PSD4; ARAP3; CHMP3; VPS26B; TGFBR2; ZFYVE16

Protein Function

SNX4 has several biochemical functions, for example, epidermal growth factor receptor binding, insulin receptor binding, leptin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNX4 itself. We selected most functions SNX4 had, and list some proteins which have the same functions with SNX4. You can find most of the proteins on our site.
Function
Related Protein
Function epidermal growth factor receptor binding
Related Protein CBLC; PLSCR1; ARF4; SNX1; EFEMP1; SHC1; AGR2; MS4A1; Fert2; ERBB4
Function insulin receptor binding
Related Protein INSL3; PTPN1; PTPN11; DOK1B; SLC2A2; SHC1; FRS2; PHIP; DOK6; SNX2
Function leptin receptor binding
Related Protein SNX2; SNX4; SNX1
Function phosphatidylinositol binding
Related Protein HIP1; SNX9B; SNX32; SNX27A; SNX10A; SNX27; NISCH; SNX8; RAG2; SNX29
Function protein binding
Related Protein PIK3C3; GPR85; ZBTB7A; RAB3C; ZSCAN1; SCO1; JMJD7; EZH2; ANXA10; SORCS1
Function transferrin receptor binding
Related Protein Trf; TF; CD81; SNX2; SNX4; SNX1; RGMA; HFE; HFE2

Interacting Protein

SNX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SNX4.
MAGEA6; ARL6IP1; BIN1; Bin1; SNX30; SNX7; SUPT5H; brrf1_ebvg; HIVEP1

SNX4 Related Articles

Ghai, R; Tello-Lafoz, M; et al. Phosphoinositide binding by the SNX27 FERM domain regulates its localization at the immune synapse of activated T-cells. JOURNAL OF CELL SCIENCE 128:553-565(2015).
Tseng, HY; Thorausch, N; et al. Sorting Nexin 31 Binds Multiple beta Integrin Cytoplasmic Domains and Regulates beta 1 Integrin Surface Levels and Stability. JOURNAL OF MOLECULAR BIOLOGY 426:3180-3194(2014).