SOS1

Official Full Name

son of sevenless homolog 1 (Drosophila)
Overview

This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008]
Synonyms

SOS1;son of sevenless homolog 1 (Drosophila);GF1;HGF;NS4;GGF1;GINGF;son of sevenless homolog 1;SOS-1;guanine nucleotide exchange factor;gingival fibromatosis, hereditary, 1

Cat.#	Product name	Source (Host)	Species	Tag	Protein Length	Price
SOS1-5322Z	Recombinant Zebrafish SOS1	Mammalian Cells	Zebrafish	His		Inquiry
SOS1-1568HCL	Recombinant Human SOS1 293 Cell Lysate	HEK293	Human	Non		Inquiry
SOS1-13H	Recombinant Human SOS1 Protein, His-tagged	E.coli	Human	His	563-1049 a.a.	Inquiry
SOS1-38H	Active Recombinant Human SOS1 Protein (564-1049), N-His tagged	E.coli	Human	His	564-1049	Inquiry

Involved Pathway

SOS1 involved in several pathways and played different roles in them. We selected most pathways SOS1 participated on our site, such as MAPK signaling pathway,ErbB signaling pathway,Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
FoxO signaling pathway	BCL6,RAF1,GRB2A,BRAF,PRMT1,CAT,BCL6A,MAP2K1,IKBKB,SGK2
Prolactin signaling pathway	PRL,SHC4,PIK3R3,NEK3,PRLR,SOCS4,STAT1,FOS,PIK3CB,MAPK9
Endometrial cancer	AXIN2,CCND1,CTNNA3,PIK3CA,CTNNA2,MAP2K1,CASP9,FOXO3,PIK3R3,GSK3B
Chemokine signaling pathway	CCR1,GM1987,CRK,PIK3CA,GRK4,CCL4L2,ITK,WAS,CXCL13,SHC4
Jak-STAT signaling pathway	IFNAR1,IL21R,IFNK,PIK3R5,SOCS5B,CRFB16,PIM1,CNTF,GH1,IL6
Choline metabolism in cancer	PLD1,PIK3CA,WASF3,PPAP2A,PIK3R3,PPAP2B,PLA2G4A,MAPK1,RALGDS,CHKB
Acute myeloid leukemia	TCF7L2,PML,EIF4EBP1,AKT1,PIK3R2,STAT5A,MAP2K2,CCNA1,RAF1,MAPK3
T cell receptor signaling pathway	ZAP70,PPP3CA,PAK7,DLG1,PTPRC,MAPK13,MUC1,MAPK11,PIK3R1,RAF1
Natural killer cell mediated cytotoxicity	MAPK1,IFNGR1,HLA-C,PTPN11,IFNA5,KLRD1,HLA-E,PIK3R5,PTPN6,PIK3CB

Protein Function

SOS1 has several biochemical functions, for example, DNA binding,GTPase activator activity,Ras guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SOS1 itself. We selected most functions SOS1 had, and list some proteins which have the same functions with SOS1. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	POT1A,POLR1C,NR1D4A,LEMD3,ZBED1,EF1,THAP5,JUNB,DUX3,TCEB3C
Rho guanyl-nucleotide exchange factor activity	FGD6,ARHGEF33,ARHGEF11,PLEKHG4,PLEKHG3,KALRNB,ABR,ARHGEF39,FGD4A,ARHGEF17
SH3 domain binding	ARHGAP31,HCLS1,MYPN,GPX1,ADAM17,CIT,PARK2,VASP,CBLC,REPS1
protein heterodimerization activity	INHBA,UGT1A6,IL12A,MICU1,BOK,CUL3,TERF1,PEF1,PDGFB,SOX32
protein binding	RAD23A,THAP8,PLEKHF1,SELS,RRP7A,ACVR1B,BCL2L13,S100A14,SDC1,FGFR1OP2
Ras guanyl-nucleotide exchange factor activity	RAB3A,RASGEF1B,RASGRP1,RASGEF1A,RGL2,ADRB1,RASGEF1BB,RAPGEF5,RASGRP4,RASGEF1BA
GTPase activator activity	RGS9A,ACAP3B,AXIN2,GDI2,GDI1,DLC1,RIC8A,TBC1D10B,SH3BGRL3,STXBP5L

Interacting Protein

SOS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOS1.

GRB2