sos1
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  • Official Full Name
  • son of sevenless homolog 1 (Drosophila)
  • Background
  • This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008]
  • Synonyms
  • SOS1; son of sevenless homolog 1 (Drosophila); GF1; HGF; NS4; GGF1; GINGF; son of sevenless homolog 1; SOS-1; guanine nucleotide exchange factor; gingival fibromatosis, hereditary, 1;
Cat.#:SOS1-5322ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SOS1
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Cat.#:SOS1-1568HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human SOS1 293 Cell Lysate
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Involved Pathway

SOS1 involved in several pathways and played different roles in them. We selected most pathways SOS1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
RPS6KA4; TGFBR1A; AKT2; CACNA1SB; MAP3K5; CACNA1G; FGFR1; PPP3R1B; MAP4K3; MAP3K2
ErbB signaling pathway
MAPK8B; PLCG1; PIK3R2; CAMK2D; PAK1; PRKCBA; NRG2B; ERBB4; MAPK8A; AKT3A
Ras signaling pathway
FGF6; PAK7; FOXO4; FGF20; PLCG1; NRAS; SOS1; NGF; SHC1; PIK3CD
Chemokine signaling pathway
CCL21B; CXCR5; CCL17; Ccl9; CXCR4; WAS; PIK3CB; CXCL10; CCR9; PTK2
FoxO signaling pathway
FOXG1A; PRMT1; ATG12; NLK2; IGF1; HRASA; INS2; MAPK12B; BNIP3; RBL2
Phospholipase D signaling pathway
GAB1; AGTR1A; CYTH2; MS4A2; PIK3R3; INSR; RRAS; PPAP2C; CXCR2; PLCB4
PIK-Akt signaling pathway
YWHAB; IL4R; TSC2; PPP2R5C; FGFR3; RELA; MAPK3; KIT; ITGB8; FGF8
Dorso-ventral axis formation
PIWIL1; CPEB1; EGFRA; SPIRE2; SOS1; GRB2; ETV7; FMN2; ETS2; SPIRE1A
Focal adhesion
MAP2K1; ITGB3B; Itga10&Itgb1; ITGA9; ROCK2; CAPN2L; VCLA; CAPN2B; MYLK; PIK3CD
Gap junction
TUBA4L; ADRB3B; DRD2L; GNA15.4; HTR2C; CSNK1DA; PRKACAB; MAP2K5; GUCY1A3; PLCB3
Jak-STAT signaling pathway
PIK3CG; IL13RA1; IL-15RA; AOX4; PRL; FHL1B; IL22; CCND1; IL6; Ifna15
Natural killer cell mediated cytotoxicity
ICAM2; SYK; FCGR4; KIR2DS2; SH3BP2; HLA-E; KLRC4-KLRK1; Raet1c; PRF1; TNFRSF10C
T cell receptor signaling pathway
CD28; CD8A; PAK2; NFATC1; GRAPA; CD3E; CD3D; MAP3K14; NRAS; CD8B1; PIK3CB
B cell receptor signaling pathway
BTK; MAPK1; RAC2; BANK1; PTPN18; PILRB; IFITM1; VAV1; ARPC4; IKBKB
Fc epsilon RI signaling pathway
PLA2G4D; MAP2K4; PIK3R5; RAF1; IL3; MAPK10; MAP2K7; MAP2K6; MAPK3; IL4
Neurotrophin signaling pathway
ZFP110; MAGED1; GRB2; NTRK3; ARHGDIA; PLCG2; IRAK1; CAMK2B; RAF1; PSEN2
Regulation of actin cytoskeleton
MRAS; ACTN2B; ACTN2; INS1; Itga10&Itgb1; DIAPH1; ITGA10; MAPK6; SCINLA; MYL9B
Insulin signaling pathway
PRKACB; HK2; MAP2K2A; ACACB; IRS1; PPP1R3B; CALML5; PHKA2; CALML3; PRKAR1A
GnRH signaling pathway
ADCY1B; PRKCDA; CAMK2D; GNA11B; MAPK11; CACNA1C; ATF4B1; CALM; FSHB; CALM1B
Estrogen signaling pathway
PRKACA; GABBR2; AKT1; NOS3; KCNJ9; MAPK1; CREB3L1; HSPA6; SHC1; OPRM1
Prolactin signaling pathway
SHC2; SOCS5; PIK3R5; SOCS1; AKT2; SHC1; NEK3; SHC4; HRAS; SLC2A2
Alcoholism
GRIN3B; PDYN; HIST1H3D; HDAC11; GNAO1; ADORA2B; HDAC4; NPY; HIST1H4I; CALML5
Hepatitis C
EIF2AK1; PIK3R2; RXRA; CLDN9; OAS1B; PIK3CD; NFKBIA; OCLN; CLDN20; EIF2AK3
Pathways in cancer
BIRC5; RAC1; FGF1; BIRC8; AKT1; LAMA1; GSK3B; CCNA1; GNB1; GNB2
Proteoglycans in cancer
ITPR3; HPSE2; CAMK2G; WNT8A; PTK2; FGF2; PLAUR; PPP1R12B; PPP1R12A; FZD3
MicroRNAs in cancer
BCL2L2; PDGFRB; PDGFB; APC2; TNXB; SOS1; IKBKB; SLC7A1; HNRNPK; TP63
Renal cell carcinoma
FH1; RBX1; GAB1; SOS1; PIK3CB; FLCN; ARNT2; NRAS; PIK3R2; PAK3
Endometrial cancer
NRAS; PIK3R2; ARAF; PIK3R3; PIK3CB; AXIN2; PIK3CD; ELK1; SOS1; MAP2K2
Glioma
PIK3CD; PTEN; PIK3CG; RAF1; PIK3R2; CAMK2B; MAPK1; RB1; CALM3; SHC4
Prostate cancer
IKBKG; CCNE1; CREB3L2; CPN1; SPINK1; PIK3CB; HRAS; PIK3R1; PIK3CG; ERBB2
Chronic myeloid leukemia
HDAC1; RELA; AKT1; NFKB1; PTPN11; NFKBIA; CTBP2; TRP53; IKBKG; AKT2
Acute myeloid leukemia
IKBKB; PIK3CD; PPARD; CCNA1; MAP2K2; RAF1; PIM2; RPS6KB1; PIK3R5; GRB2
Non-small cell lung cancer
TRP53; RAF1; GRB2; BRAF; NRAS; PIK3R2; SOS1; FHIT; RXRA; STK4
Choline metabolism in cancer
AKT2; PLD1; TAE1; WASL; PIP5K1B; DGKE; SLC22A5; DGKZ; GRB2; SP1

Protein Function

SOS1 has several biochemical functions, for example, DNA binding, GTPase activator activity, Ras guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SOS1 itself. We selected most functions SOS1 had, and list some proteins which have the same functions with SOS1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ERG; C19orf40; HOXB7A; ZNF225; TNP1; ZNF620; ZFP524; FOXC1; HER3; SP140
Function GTPase activator activity
Related Protein RANGAP1B; SH3BGRL3; TBC1D7; GDI2; RABGAP1; EVI5; TBC1D9; NIPAL1; ARHGDIA; GDI1
Function Ras guanyl-nucleotide exchange factor activity
Related Protein SOS1; RASGEF1A; RGL2; RAPGEF5; ADRB1; RASGEF1BA; RASGRP1; RASGEF1B; KNDC1; RASGRP3
Function Rho guanyl-nucleotide exchange factor activity
Related Protein C3A.1; ARHGEF39; ITSN2B; ARHGEF7A; QUO; FGD4A; FARP1; OBSCN; PREX1; ECT2
Function SH3 domain binding
Related Protein PTPN12; CD3E; SOS1; CBL; ARHGAP31; DENND1A; INPP5J; ELMO3; INPP5D; MAPT
Function protein binding
Related Protein PRF1; MAPK4; C6orf211; MAGEA11; CUL3; OSBP; ABHD16A; TMPO; EPOR; CAML
Function protein heterodimerization activity
Related Protein DDIT3; Itgam&Itgb2; HIST1H3A; MYO5A; PRSS28; EXT2; TCF3A; GM5506; ARNT; PPP3CA

Interacting Protein

SOS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOS1.
GRB2