SOS1

Official Full Name

son of sevenless homolog 1 (Drosophila)
Overview

This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008]
Synonyms

SOS1;son of sevenless homolog 1 (Drosophila);GF1;HGF;NS4;GGF1;GINGF;son of sevenless homolog 1;SOS-1;guanine nucleotide exchange factor;gingival fibromatosis, hereditary, 1

Cat.#	Product name	Source (Host)	Species	Tag	Protein Length	Price
SOS1-5322Z	Recombinant Zebrafish SOS1	Mammalian Cells	Zebrafish	His		Inquiry
SOS1-1568HCL	Recombinant Human SOS1 293 Cell Lysate	HEK293	Human	Non		Inquiry
SOS1-13H	Recombinant Human SOS1 Protein, His-tagged	E.coli	Human	His	563-1049 a.a.	Inquiry
SOS1-38H	Active Recombinant Human SOS1 Protein (564-1049), N-His tagged	E.coli	Human	His	564-1049	Inquiry

Involved Pathway

SOS1 involved in several pathways and played different roles in them. We selected most pathways SOS1 participated on our site, such as MAPK signaling pathway,ErbB signaling pathway,Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Glioma	MAPK1,IGF1,SHC2,PIK3CA,MDM2,TGFA,PIK3R5,PLCG2,PIK3CG,CAMK2A
Regulation of Actin Cytoskeleton	MYLPFA,CFL2,FGF12,ARHGEF7,PFN4,F2R,ITGB1,ITGB5,MYL10,ARPC5LB
Endometrial cancer	MLH1,PIK3CD,AXIN1,ARAF,BRAF,MAP2K2,NRAS,GRB2,ERBB2,HRAS
Ras signaling pathway	GNB1,GRIN1,FGF20,PLA2G6,RAF1,ARF6,LAT,RELA,PRKACG,FGF5
Choline metabolism in cancer	MAPK9,TSC2,DGKE,PDGFA,DGKB,WASF2,SLC22A2,SLC22A5,DGKA,NRAS
Renal cell carcinoma	PIK3R1,PAK7,AKT1,FLCN,PIK3CB,VHL,MET,PIK3R2,SLC2A1,EGLN2
T cell receptor signaling pathway	PIK3CA,MAP3K7,PPP3CC,DLG1,FOS,GRAP2,LCK,PIK3R5,CD3E; CD3D,CD8B
Insulin signaling pathway	PYGB,INSRB,PRKAG3B,PYGMA,BRAF,PRKCI,PHKG2,EIF4E2RS1,TRIP10A,INS2
ErbB signaling pathway	BADB,CBLB,HRASA,RAF1B,SHC3,CAMK2D,PAK2,SHC4,MAP2K7,CDKN1BB

Protein Function

SOS1 has several biochemical functions, for example, DNA binding,GTPase activator activity,Ras guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SOS1 itself. We selected most functions SOS1 had, and list some proteins which have the same functions with SOS1. You can find most of the proteins on our site.

Function	Related Protein
Ras guanyl-nucleotide exchange factor activity	RASGRP4,RASGRP3,RASGRP1,RAB3A,KNDC1,RASGEF1A,RAPGEF4,RASGEF1B,RGL2,RASGEF1BA
GTPase activator activity	AGAP2,LRRK2,RGS9B,OPHN1,LLGL2,TBC1D7,RAB3GAP2,CDC42EP1,USP6NL,RGS3A
SH3 domain binding	SHANK3,FMN1,KHDRBS1,GJA1,AFAP1L2,SH3BP5LA,CIT,PAK3,LRP2,PLSCR4
protein binding	NLRC5,BAIAP2L1,CCDC28B,EIF5A,PLIN5,BRD3,SHD,SPTSSA,PKN2,ITGB7
DNA binding	ZNF786,CHD4,E2F1,ZNF266,ZFP541,POU3F3,TMPOB,PTF1A,TAF1L,NEUROD6B
protein heterodimerization activity	GUCY1A3,HIST1H2AA,UGT1A3,PVALB,JAM3,TBX18,SEPHS1,USF1,RRAGD,HIST1H2AK
Rho guanyl-nucleotide exchange factor activity	DOCK11,ARHGEF25,ARHGEF19,VAV2,AKAP13,TRIOA,ARHGEF39,PLEKHG5,FARP1,PLEKHG3

Interacting Protein

SOS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOS1.

GRB2