SOS1

  • Official Full Name

    son of sevenless homolog 1 (Drosophila)
  • Overview

    This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008]
  • Synonyms

    SOS1;son of sevenless homolog 1 (Drosophila);GF1;HGF;NS4;GGF1;GINGF;son of sevenless homolog 1;SOS-1;guanine nucleotide exchange factor;gingival fibromatosis, hereditary, 1
Cat.# Product name Source (Host) Species Tag Protein Length Price
SOS1-5322Z Recombinant Zebrafish SOS1 Mammalian Cells Zebrafish His
SOS1-1568HCL Recombinant Human SOS1 293 Cell Lysate HEK293 Human Non
SOS1-13H Recombinant Human SOS1 Protein, His-tagged E.coli Human His 563-1049 a.a.
SOS1-38H Active Recombinant Human SOS1 Protein (564-1049), N-His tagged E.coli Human His 564-1049

    Involved Pathway

    SOS1 involved in several pathways and played different roles in them. We selected most pathways SOS1 participated on our site, such as MAPK signaling pathway,ErbB signaling pathway,Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hepatitis C EIF3E,ARAF,AKT2,MAPK9,PIK3R3,PIK3R2,OSTN,IFNA13,AKT1,IKBKG
    Natural killer cell mediated cytotoxicity ULBP1,KIR2DS2,IFNG,FCGR3A,HRAS,GM-CSF,SH3BP2,Ifna11,SHC4,IFNA16
    Acute myeloid leukemia PIM2,PIK3CG,RPS6KB1,KIT,MAP2K1,PIK3R5,MTOR,JUP,LEF1,PIK3CA
    Estrogen signaling pathway SHC4,Adcy4,MMP9,KCNJ9,MAPK1,FKBP4,HSPA2,GNAO1,PIK3CA,NOS3
    Regulation of Actin Cytoskeleton FGF20,MYL5,MAP2K2B,PAK2A,PIK3R3B,ACTN2,VCLA,FGFR1,PDGFAB,ITGB6
    MAPK signaling pathway RAF1B,MKNK1,PPP3R1B,CACNG6,GADD45BB,MINK1,PPP3CCB,CACNA2D1A,MEF2C,PRKACAB
    Choline metabolism in cancer PRKCG,PIP5K1A,PLD2,PCYT1A,MAPK8,DGKG,PIK3CD,DGKB,EIF4EBP1,RHEB
    FoxO signaling pathway PIK3CA,Fasl,HRASB,S1PR4,INSRB,CCNB2,SIRT1,KLF2,IGF1R,PLK2B
    MicroRNAs in cancer PTGS2,NOTCH2,NOTCH3,EP300,BAK1,HDAC1,ZEB1,MDM4,KIF23,PLCG2

    Protein Function

    SOS1 has several biochemical functions, for example, DNA binding,GTPase activator activity,Ras guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SOS1 itself. We selected most functions SOS1 had, and list some proteins which have the same functions with SOS1. You can find most of the proteins on our site.

    Function Related Protein
    protein heterodimerization activity UGT1A6,NR4A2,HIST1H4J,GM5506,TLR6,IKBKB,HIST1H2BD,MYOD1,BMP2,DDX1
    DNA binding ZNF624,ZNF404,ZEB1B,POLE2,SMARCC1,POLD2,ZBP1,GTF2F1,XRCC5,SETBP1
    GTPase activator activity GDI1,TBC1D3B,ALDH1A2,GAPVD1,ARAP2,EVI5L,ELMOD2,RANGAP1A,WNT11,PGAM5
    Rho guanyl-nucleotide exchange factor activity ARHGEF1A,ARHGEF10L,ITSN1,ALS2CL,PLEKHG2,KALRNB,RASGRF2,ARHGEF7B,ARHGEF3,DOCK10
    protein binding ARHGEF15,EYA1,CYHR1,HLA-DRB3,ANKFY1,SRM,AMMECR1,BCAM,MINK1,TRAM2
    SH3 domain binding ARHGAP27,UVRAG,DRD4,QK,EPS15,ADAM15,SH2D2A,ABL1,FMNL3,ITGB1BP2
    Ras guanyl-nucleotide exchange factor activity RAPGEF5,RASGEF1BA,RAPGEF4,RASGRP4,RAB3A,RASGRP1,ADRB1,RASGRP3,RGL2,RASGEF1BB

    Interacting Protein

    SOS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOS1.

    GRB2

    SOS1 Related Signal Pathway

    Resources

    References

    Ask a Question for All SOS1 Products

    Required fields are marked with *

    My Review for All SOS1 Products

    Required fields are marked with *