sppl2b
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  • Official Full Name
  • signal peptide peptidase like 2B
  • Background
  • This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • SPPL2B; signal peptide peptidase like 2B; IMP4; PSH4; PSL1; IMP-4; signal peptide peptidase-like 2B; SPP-like 2B; intramembrane protease 4; presenilin-like protein 1; presenilin homologous protein 4;
Cat.#:SPPL2B-5721RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SPPL2B Protein
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Cat.#:SPPL2B-2622CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SPPL2B
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Cat.#:SPPL2B-1500HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human SPPL2B 293 Cell Lysate
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Protein Function

SPPL2B has several biochemical functions, for example, aspartic endopeptidase activity, intramembrane cleaving, NOT aspartic endopeptidase activity, intramembrane cleaving, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPPL2B itself. We selected most functions SPPL2B had, and list some proteins which have the same functions with SPPL2B. You can find most of the proteins on our site.
Function
Related Protein
Function aspartic endopeptidase activity, intramembrane cleaving
Related Protein HM13; SPPL3; SPPL2B
Function NOT aspartic endopeptidase activity, intramembrane cleaving
Related Protein SPPL2B
Function protein binding
Related Protein ARHGDIG; DHRS1; FAM53C; EIF4EBP2; C19orf44; P4HA2; EIF3A; TUBB4A; SCRIB; RPL37A
Function protein homodimerization activity
Related Protein PDGFC; NADK2; NTRK2; TKT; HER5; SUMF1; SRGAP2; UPK1A; BMP7A; ASNSD1

Interacting Protein

SPPL2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPPL2B here. Most of them are supplied by our site. Hope this information will be useful for your research of SPPL2B.
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