sptbn2
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  • Official Full Name
  • spectrin, beta, non-erythrocytic 2
  • Background
  • Spectrins are principle components of a cells membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.
  • Synonyms
  • SPTBN2; spectrin, beta, non-erythrocytic 2; SCA5, spinocerebellar ataxia 5; spectrin beta chain, brain 2; beta-III spectrin; spectrin, non-erythroid beta chain 2; glutamate transporter EAAT4-associated protein 41; SCA5; GTRAP41
Cat.#:SPTBN2-30886THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SPTBN2, His-tagged
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Cat.#:SPTBN2-5728RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SPTBN2 Protein
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Involved Pathway

SPTBN2 involved in several pathways and played different roles in them. We selected most pathways SPTBN2 participated on our site, such as ARMS-mediated activation, Adaptive Immune System, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPTBN2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ARMS-mediated activation
DUSP2; DUSP7; FRS3; PEBP1; AKAP9; DUSP10; FGF8B; FGF20A; DLG4; SPRED1
Adaptive Immune System
ACTR1B; CXADR; FBXO17; CD300LD; CYBA; FRS2A; TRIM41; SIGLEC9; NRG2A; RNF111
Axon guidance
COL4A4; RAC1; CREB1B; PEA15A; SEMA4A; RHOA; RHOAE; NRG3; EFNA3B; ARPC1B
Cytokine Signaling in Immune system
CSF2RB; OASL; MAP3K8; EIF4EB; PHB; NUPL2; FGF20A; IFIT8; TRIM6; EIF4G2
DAP12 interactions
FRS2B; JAK3; CLEC5A; AGO1; PAQR3A; LAMTOR2; SPTBN2; PEBP1; FRS2; AGO3
DAP12 signaling
SPTA1; WDR83; PEA15; AGO3; AGO1; KLB; FRS2B; DUSP7; FRS2; CSF2RA
Developmental Biology
MED18; COL9A1A; LGI1; KALRNB; HFE2; NTN1B; COL6A3; CEBPA; MED26; PRDM14
Downstream signal transduction
RASGEF1A; FGF8B; DAB2IPB; SPRED2; MARK3; DUSP2; SPTBN1; DUSP10; CNKSR1; WDR83

Protein Function

SPTBN2 has several biochemical functions, for example, actin binding, phospholipid binding, structural constituent of cytoskeleton. Some of the functions are cooperated with other proteins, some of the functions could acted by SPTBN2 itself. We selected most functions SPTBN2 had, and list some proteins which have the same functions with SPTBN2. You can find most of the proteins on our site.
Function
Related Protein
Function actin binding
Related Protein DMTN; MICAL2; MYPN; ACTN2B; KLHL20; PLEKHH2; SPTBN2; HOMER2; ACTR2B; MSRB2
Function phospholipid binding
Related Protein PACSIN1; SHC1; SGIP1; SPTBN2; PAFAH2; RASAL1; ANXA1; LC3; PACSIN1A; APOM
Function structural constituent of cytoskeleton
Related Protein TUBB6; TUBA1A; MSN; SPTBN1; TUBA1L; TPM1; ACTL6B; DSP; BFSP2; TUBA3E

Interacting Protein

SPTBN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPTBN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPTBN2.
Cdk1; ATAD2; APC; p29991-pro_0000037940; p29991-pro_0000037946; BKRF1; CELSR3; MYO1C; Aurkb; FLNA; MYH9; IQGAP1; CAPZA2; PPP1CB; k7_vaccw; Bod1; SYNPO; Myh9