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ST6GALNAC4

Official Full Name

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
Overview

The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein prefers glycoproteins rather than glycolipids as substrates and shows restricted substrate specificity, utilizing only the trisaccharide sequence Neu5Ac-alpha-2,3-Gal-beta-1,3-GalNAc. In addition, it is involved in the synthesis of ganglioside GD1A from GM1B. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Transcript variants encoding different isoforms have been found for this gene.
Synonyms

ST6GALNAC4; ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; sialyltransferase 7D ((alpha N acetylneuraminyl 2,3 beta galactosyl 1,3) N acetyl galactosaminide alpha 2,6 sialyltransferase) , SIA;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Cynomolgus Monkey
Human
Zebrafish

Source

HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	ST6GALNAC4-1436HCL	Recombinant Human ST6GALNAC4 293 Cell Lysate	HEK293	N/A	Inquiry
Cynomolgus Monkey	ST6GALNAC4-981C	Recombinant Cynomolgus ST6GALNAC4 Protein, His-tagged	Mammalian Cell	His	Inquiry
Cynomolgus Monkey	ST6GALNAC4-724C	Recombinant Cynomolgus Monkey ST6GALNAC4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Cynomolgus Monkey	ST6GALNAC4-724C-B	Recombinant Cynomolgus Monkey ST6GALNAC4 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	ST6GALNAC4-4344Z	Recombinant Zebrafish ST6GALNAC4	Mammalian Cell	His	Inquiry
Chicken	ST6GALNAC4-6080C	Recombinant Chicken ST6GALNAC4	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein

ST6GALNAC4 involved in several pathways and played different roles in them. We selected most pathways ST6GALNAC4 participated on our site, such as Glycosphingolipid biosynthesis - ganglio series, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ST6GALNAC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Glycosphingolipid biosynthesis - ganglio series	B4GALNT1;ST8SIA1;ST8SIA5;ST6GALNAC3;ST3GAL1;HEXA;ST3GAL2;ST3GAL5;GLB1
Metabolic pathways	PGD;PRPS1;AK1;C1GALT1B;GATM;UQCRH;B3GALT4;NT5C3A;NDUFA11

ST6GALNAC4 has several biochemical functions, for example, (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity, alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity, sialyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ST6GALNAC4 itself. We selected most functions ST6GALNAC4 had, and list some proteins which have the same functions with ST6GALNAC4. You can find most of the proteins on our site.

Function	Related Protein
(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	ST6GALNAC6;ST6GALNAC5B;ST6GALNAC3;ST6GALNAC1;ST6GALNAC4;ST6GALNAC1.2;ST6GALNAC5
sialyltransferase activity	ST6GALNAC1;ST3GAL5L;ST6GALNAC5;ST6GALNAC6;ST6GALNAC4;ST8SIA3;ST6GAL2B;ST3GAL3B;ST3GAL5

ST6GALNAC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ST6GALNAC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ST6GALNAC4.

SPATA20