SULT2A1

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SULT2A1

Official Full Name sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
Background Dehydroepiandrosterone sulfate or DHEA sulfate is a metabolite of dehydroepiandrosterone (DHEA) produced by the addition of a sulfate group, catalyzed by the sulfotransferase enzymes SULT1A1 and SULT1E1, which also produce estrone sulfate from estrone. DHEA sulfate can also be back-converted to DHEA through the action of steroid sulfatase.In the zona reticularis layer of the adrenal cortex, DHEA-sulfate is generated by SULT2A1. This layer of the adrenal cortex is thought to be the primary source of serum DHEA-sulfate. DHEA sulfate levels decline as a person ages as the reticularis layer diminishes in size.
Synonyms Alcohol/hydroxysteroid sulfotransferase; Bile salt sulfotranasferase 2A1; Bile salt sulfotransferase; Dehydroepiandrosterone sulfotransferase; DHEA ST; DHEA-ST; DHEAS; EC 2.8.2.14; HST; hSTa; Hydroxysteroid Sulfotransferase; ST2; ST2A1; ST2A1_HUMAN; ST2A3; STD Sulfotransferase 2A1; Sulfotransferase family cytosolic 2A dehydroepiandrosterone (DHEA) preferring member 1; Sult2a1
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Mammalian Cell
    • Mouse
    • Tag :
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SULT2A1-3472H Recombinant Human SULT2A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human SULT2A1-92H Recombinant Human SULT2A1 Protein E. coli
    Human CAB11609MH Mouse Monoclonal Antibody to Human Sulfotransferase Family, Cytosolic, 2A, Dehydroepiandrosterone-Preferring, Member 1 Mouse N/A
    Human SULT2A1-1349HCL Recombinant Human SULT2A1 293 Cell Lysate HEK293 N/A
    Human SULT2A1-1782H Recombinant Human Sulfotransferase Family, Cytosolic, 2A, Dehydroepiandrosterone (DHEA)-Preferring, Member 1, His-tagged Human His
    Human SULT2A1-3050H Recombinant Human SULT2A1, His-tagged E.coli His
    Human SULT2A1-3088H Recombinant Human SULT2A1, His tagged E.coli His
    Human SULT2A1-3543H Recombinant Human SULT2A1 Protein, His-tagged E.coli His
    Human SULT2A1-3545H Recombinant Human SULT2A1, His-tagged E.coli His
    Mouse SULT2A1-16224M Recombinant Mouse SULT2A1 Protein Mammalian Cell His
    Rat SULT2A1-5834R Recombinant Rat SULT2A1 Protein Mammalian Cell His

    SULT2A1 involved in several pathways and played different roles in them. We selected most pathways SULT2A1 participated on our site, such as Metabolism of xenobiotics by cytochrome P, Bile secretion, Chemical carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SULT2A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism of xenobiotics by cytochrome P UGT1A2; AKR7A3; GSTM; ALDH3B2; GSTA1; MGST1.1; GSTA2; UGT1A7C; CBR1L; DHDHL
    Bile secretion SLCO1A4; ADCY3; ATP1A3; PRKACA; NR0B2; ABCB11; LDLR; OSTB; SLCO1B2; ABCB4
    Chemical carcinogenesis UGT1A2; CYP2E1; CYP3A43; UGT1A6; UGT2A1; EPHX1; GSTA2; ALDH3B2; ADH2-2; SULT1A3

    SULT2A1 has several biochemical functions, for example, bile-salt sulfotransferase activity, protein binding, sulfotransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SULT2A1 itself. We selected most functions SULT2A1 had, and list some proteins which have the same functions with SULT2A1. You can find most of the proteins on our site.

    Function Related Protein
    bile-salt sulfotransferase activity SULT2A1
    protein binding UBE2L3; PDZD3; SLC35A2; ODF1; PRDM4; GAPDH; GPRIN2; CDKN2C; FASTKD5; OSGIN1
    sulfotransferase activity SULT1A2; CHST3A; Sult2a2; SULT5A1; CHST2; SULT1C2; HS6ST1A; SULT6B1; HS3ST1L1; HS3ST3B1A

    SULT2A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SULT2A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SULT2A1.

    SULT1B1; STAT3; PRDX4; STK3; TMX1

    Fujimura, H; Murakami, N; et al. The suitability of rat hepatoma cell line H4IIE for evaluating the potentials of compounds to induce CYP3A23 expression. EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY 64:527-533(2012).
    Gong, JC; Gan, JP; et al. Identification of the Oxidative and Conjugative Enzymes Involved in the Biotransformation of Brivanib. DRUG METABOLISM AND DISPOSITION 40:219-226(2012).

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