tcf12
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  • Official Full Name
  • transcription factor 12
  • Background
  • The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
  • Synonyms
  • TCF12; transcription factor 12; bHLHb20; HEB; helix loop helix transcription factor 4; HsT17266; HTF4; TCF-12; E-box-binding protein; DNA-binding protein HTF4; transcription factor HTF-4; helix-loop-helix transcription factor 4; class B basic helix-loop-h
Cat.#:TCF12-3157HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TCF12, His-tagged
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Cat.#:TCF12-582HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TCF12 Protein, His-tagged
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Cat.#:TCF12-5988RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TCF12 Protein
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Cat.#:TCF12-6927CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TCF12
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Cat.#:TCF12-12825ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TCF12
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Cat.#:TCF12-1183HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human TCF12 293 Cell Lysate
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Involved Pathway

TCF12 involved in several pathways and played different roles in them. We selected most pathways TCF12 participated on our site, such as CDO in myogenesis, Developmental Biology, Id Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCF12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
CDO in myogenesis
CDH2; TCF4; MYOG; TCF12; MYF6; TCF3B; SPAG9; CDON; CDH4; MYOD1
Developmental Biology
TRPC3; CLTC; LIN28A; RHOC; CDH4; ST8SIA2; DUSP9; DAB2IPB; AP2M1; FGF20A
Id Signaling Pathway
KDR; ACVRL1; MYF6; PAX2; MSC; TCF12; MYOG; MYOD1; ELK3; IFI16
Myogenesis
MEF2B; BNIP2; SPAG9; MYOG; CDH4; MYOD1; TCF12; MEF2AA; TCF4; TCF3A

Protein Function

TCF12 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, SMAD binding, bHLH transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TCF12 itself. We selected most functions TCF12 had, and list some proteins which have the same functions with TCF12. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein ZIC1; CEBPG; NFATC4; TCF4; MEF2A; TFE3; TBX20; ZNF217; FEZF2; MYOD1
Function SMAD binding
Related Protein PURA; FKBP1A; TGFBR3; TCF12; SMURF2; EID2; RNF111; HIPK2; TOB1; HMGA2
Function bHLH transcription factor binding
Related Protein HAND1; ASCL1; TCF3B; ISL1; TCF12; SMAD3; SIRT1; LMO2; TCF3A; PSMD9
Function enhancer binding
Related Protein FOXH1; ELL3; TCF3; MESP1; RAI1; LEF1; AHR; SP1; TIPARP; SOX9
Function protein binding
Related Protein ATP2C2; GAK; RPL11; PAK1IP1; CBX4; EXOC3L; TRMT12; APOH; KIF1B; DCUN1D1
Function protein heterodimerization activity
Related Protein HIF1A; VEGFB; POU5F3; SOX32; UGT1A7; ADD2; IKZF2; HIST1H4C; BAX; NPAS4
Function protein homodimerization activity
Related Protein PAFAH1B2; ATPIF1B; BCL2L2; ACTN3; MBL1; DMRT2B; IZUMO3; TWIST1; ANXA1; TYW5
Function transcription factor activity, sequence-specific DNA binding
Related Protein ATF6; CDX2; E2F4; UBN2; HIF1AL; DMRT1; MAFA; MTA1; TCF25; SPI1B
Function transcription factor binding
Related Protein C1QBP; CTBP1; NBN; SMAD2; HAND1; NFATC2; NKX3-1; PIAS2; TCF7L2; EPAS1
Function contributes_to transcription regulatory region DNA binding
Related Protein NFYC; ATF4; NR1H3; HDAC4; HAND1; NFYB; TCF3; RXRA; NFYA; TAF1
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein CAMTA2; HNRNPK; CTCFL; NKX2; CEBPE; PITX3; CREB3L2; TP53; SMAD4; MEF2C

Interacting Protein

TCF12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCF12 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCF12.
HEXIM2; MAPKBP1; CRCP; STK16; PSMA1; SRI; STAT5A

TCF12 Related Articles

di Rocco, F; Baujat, G; et al. Clinical spectrum and outcomes in families with coronal synostosis and TCF12 mutations. EUROPEAN JOURNAL OF HUMAN GENETICS 22:1413-1416(2014).
Wang, P; Cui, J; et al. Differential expression of microRNAs in 2-cell and 4-cell mouse embryos. ZYGOTE 22:455-461(2014).