tesk2
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  • Official Full Name
  • testis-specific kinase 2
  • Background
  • This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis.
  • Synonyms
  • TESK2; testis-specific kinase 2; dual specificity testis-specific protein kinase 2; testicular protein kinase 2
Cat.#:TESK2-252HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TESK2, GST-tagged
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Cat.#:TESK2-3183HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TESK2, His-tagged
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Cat.#:TESK2-6017RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TESK2 Protein
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Cat.#:TESK2-4669RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TESK2 Protein, His-tagged
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Cat.#:TESK2-6196ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TESK2
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Cat.#:TESK2-1761HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human TESK2 cell lysate
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Involved Pathway

TESK2 involved in several pathways and played different roles in them. We selected most pathways TESK2 participated on our site, such as Focal Adhesion, Regulation of Microtubule Cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with TESK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Focal Adhesion
ITGA10; IGF1; AKT3A; MYL5; MAPK1; ITGA4; PPP1R12A; PPP1CB; CCND2; VEGFA
Regulation of Microtubule Cytoskeleton
TPPP; MARK2; DPYSL2; MARK1; MAP1B; CFL2; TESK2

Protein Function

TESK2 has several biochemical functions, for example, ATP binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TESK2 itself. We selected most functions TESK2 had, and list some proteins which have the same functions with TESK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein RIPK1; CDK13; CHD4; ADCY7; CAD; ABCC5; SEPHS1; ITPKB; ACTA1A; MAPK14A
Function metal ion binding
Related Protein ZBED4; RBM4.2; CHN2; TEC; WBSCR17; RIOK3; KDM6B; RNF145B; ZNF512; B4GALT3
Function protein binding
Related Protein TLDC2; CHDH; CDC37; FAM32A; CCDC93; ATF4; HADHA; NMB; C3orf52; MAFG
Function protein kinase activity
Related Protein BMPR1AB; TLK1A; PKMYT1; DCKL1B; AURKA; SRPK1B; RPS6KA3B; TNIK; IGF1RA; NEK10
Function protein serine/threonine kinase activity
Related Protein GRK7B; ERN2; ALPK2; TTK; NEK8; VRK1; ZAK; PRKCE; ATM; TRIO
Function protein serine/threonine/tyrosine kinase activity
Related Protein DYRK2; RPS6KB1; CLK2; AURKC; CLK4; PRKACA; MAP2K2; DYRK1B; TESK1; DYRK1AA
Function protein tyrosine kinase activity
Related Protein KDRL; EPHB4A; CLK3; ERBB4A; FER; TNK2; AXL; FGR; PDGFRB; MET

Interacting Protein

TESK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TESK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TESK2.
HSP90AB1; linkable pd173955 analogue; bosutinib

TESK2 Related Articles

Jha, KN; Coleman, AR; et al. Heat Shock Protein 90 Functions to Stabilize and Activate the Testis-specific Serine/Threonine Kinases, a Family of Kinases Essential for Male Fertility. JOURNAL OF BIOLOGICAL CHEMISTRY 288:16308-16320(2013).
Motiei, M; Tavalaee, M; et al. Evaluation of HSPA2 in fertile and infertile individuals. ANDROLOGIA 45:66-72(2013).