tgfb1i1
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  • Official Full Name
  • transforming growth factor beta 1 induced transcript 1
  • Background
  • This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
  • Synonyms
  • TGFB1I1; transforming growth factor beta 1 induced transcript 1; HIC5; ARA55; HIC-5; TSC-5; transforming growth factor beta-1-induced transcript 1 protein; androgen receptor coactivator ARA55; hydrogen peroxide-inducible clone 5 protein; androgen receptor coactivator 55 kDa protein; androgen receptor-associated protein of 55 kDa;
Cat.#:TGFB1I1-652HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TGFB1I1 Protein, His-tagged
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Cat.#:Tgfb1i1-653RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tgfb1i1 Protein, His-tagged
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Cat.#:TGFB1I1-16703MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TGFB1I1 Protein
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Cat.#:TGFB1I1-6036RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TGFB1I1 Protein
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Cat.#:TGFB1I1-4686RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TGFB1I1 Protein, His-tagged
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Cat.#:TGFB1I1-1120HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TGFB1I1 293 Cell Lysate
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Involved Pathway

TGFB1I1 involved in several pathways and played different roles in them. We selected most pathways TGFB1I1 participated on our site, such as Androgen receptor signaling pathway, Coregulation of Androgen receptor activity, Monoamine Transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFB1I1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Androgen receptor signaling pathway
AES; DSTN; POU2F1B; STUB1; RHOB; CTNNB1; CDKN1A; DAXX; KAT7B; RNF6
Coregulation of Androgen receptor activity
CARM1; PA2G4; KDM1A; TGFB1I1; CTDSP1; TMF1; NRIP1; PIAS3; SNURF; PAWR
Monoamine Transport
DBH; FBXO32; SCAMP2; UNC13B; HRH3; SYN1; TGFB1I1; TPH2
Serotonin Transporter Activity
TGFB1I1; TPH2; SCAMP2

Protein Function

TGFB1I1 has several biochemical functions, for example, I-SMAD binding, Roundabout binding, androgen receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFB1I1 itself. We selected most functions TGFB1I1 had, and list some proteins which have the same functions with TGFB1I1. You can find most of the proteins on our site.
Function
Related Protein
Function I-SMAD binding
Related Protein SMAD6; CTNNB1; SMAD7; SMAD4; AXIN2; SMAD2; AXIN1; SMURF1; TGFB1I1; TGFBR1
Function Roundabout binding
Related Protein SLIT2; SLIT1B; GM4980; SLIT1A; SLIT1; UBE4A; SLIT3; TGFB1I1
Function androgen receptor binding
Related Protein RB1; KAT5; DDX5; KDM4C; PRKCBB; TCF21; RNF14; RNF4; NRIP1; KDM1A
Function protein binding
Related Protein RSL24D1; UTF1; RAB34; LRCH4; ANKHD1; PSMC6; ZNF707; AEN; MIF4GD; TRPC4
Function transcription coactivator activity
Related Protein MAML1; NCOA2; MED17; ABT1; MAX; SMARCE1; ZSCAN1; PARK7; CITED4; APEX1
Function zinc ion binding
Related Protein PRICKLE1; KAT6A; ZCCHC4; KDM1B; UBR3; RUFY1; SUV39H2; TRIM71; FHL5; DDX58

Interacting Protein

TGFB1I1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFB1I1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFB1I1.
PTK2; ITGA4; VHL; CCNA1; CDKN2B; ilvD; kdpE; kbl; HIPK3; UBQLN4; PLA2G3; q9wmx2-pro_0000037548; SH2D1B; PLEKHH2

TGFB1I1 Related Articles

Derer, S; Till, A; et al. mTNF reverse signalling induced by TNF alpha antagonists involves a GDF-1 dependent pathway: implications for Crohn's disease. GUT 62:376-386(2013).
Lai, CF; Chen, YM; et al. Cysteine-Rich Protein 61 Plays a Proinflammatory Role in Obstructive Kidney Fibrosis. PLOS ONE 8:-(2013).

TGFB1I1 Related Gene Family

TGF