|Official Full Name||transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)|
|Background||Transducin-like enhancer protein 1 is a protein that in humans is encoded by the TLE1 gene.|
|Synonyms||TLE1; transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); transducin like enhancer of split 1, homolog of Drosophila E(sp1); transducin-like enhancer protein 1; enhancer of split groucho 1; ESG; ESG1; GRG1; E(Sp1) homolog; Enhancer of split groucho like protein 1; Enhancer of split groucho-like protein 1; TLE 1; TLE1_HUMAN; Transducin like enhancer of split 1 (E(sp1) homolog Drosophila); Transducin like enhancer of split 1; Transducin like enhancer of split 1 homolog of Drosophila E(sp1); Transducin like enhancer protein 1; transducin-like enhancer of split 1, homolog of Drosophila E(sp1)|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
TLE1 involved in several pathways and played different roles in them. We selected most pathways TLE1 participated on our site, such as Deactivation of the beta-catenin transactivating complex, Degradation of beta-catenin by the destruction complex, Delta-Notch Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Deactivation of the beta-catenin transactivating complex||BCL9L; ASH2L; SOX9B; C; CTBP1; RBBP5; TLE4; TLE1; SOX7; TLE3B|
|Degradation of beta-catenin by the destruction complex||TLE3B; TLE4; AES; TLE1; CTBP2; FAM123B; CTBP1; TLE2; TLE3|
|Delta-Notch Signaling Pathway||TUBB3; MAGEA1; YY1A; TLE1; JAG2; HES6; ASCL1; ZFPM1; JAG1; HEY2|
|Formation of the beta-catenin:TCF transactivating complex||RBBP5; TLE1; BCL9L; ASH2L; TLE3; TLE4; TLE2; SMARCA4; PYGO1; CDC73|
|NOTCH1 Intracellular Domain Regulates Transcription||TLE4; TLE1; TUBB3; TLE3; HEY1; HEYL; TLE2; HEY2|
|Notch-mediated HES/HEY network||BGLAP; HEY1; GATA6; MYOD1; GATA1; ASCL1; MYB; TLE1; CTBP1; HES6|
|Presenilin action in Notch and Wnt signaling||AES; TLE1; KREMEN2; WIF1|
|Regulation of Wnt-mediated beta catenin signaling and target gene transcription||ZCCHC12; IGF2BP1; CBY1; T; TLE1; TNIK; CDX1; SALL4; TLE4; CDX4|
TLE1 has several biochemical functions, for example, RNA polymerase II transcription corepressor activity, chromatin binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TLE1 itself. We selected most functions TLE1 had, and list some proteins which have the same functions with TLE1. You can find most of the proteins on our site.
|RNA polymerase II transcription corepressor activity||SIN3AA; N4BP2L2; SIN3B; SIN3A; URI1; TBX15; TBX18; OLIG3; SOX3; ELANE|
|chromatin binding||JUB; HDAC3; ESR1; PARP1; TLE4; SAFB; CITED1; WHSC1; GATA5; SMC1A|
|identical protein binding||CALCA; PKD2; SEPT7; BNIP3; PARK2; KHDC1B; CD28; MCPH1; KCNIP2; KRTAP10-5|
|protein binding||SLC4A1; DUT; SLC7A11; FECH; CUL9; PTEN; ZKSCAN3; ZMYM4; KIR2DL4; TLR2|
|transcription factor binding||TRP53; E2F5; ZBTB49; HMGB1; SOX10; TAF12; NEUROD1; MLXIPL; FOXA3; FOS|
TLE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLE1.
RUNX1; RUNX3; TK1; DAZAP2; HIPK2; SYT-SSX2