TLE1 Protein, transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)


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Official Full Name transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
Background Transducin-like enhancer protein 1 is a protein that in humans is encoded by the TLE1 gene.
Synonyms TLE1; transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); transducin like enhancer of split 1, homolog of Drosophila E(sp1); transducin-like enhancer protein 1; enhancer of split groucho 1; ESG; ESG1; GRG1; E(Sp1) homolog; Enhancer of split groucho like protein 1; Enhancer of split groucho-like protein 1; TLE 1; TLE1_HUMAN; Transducin like enhancer of split 1 (E(sp1) homolog Drosophila); Transducin like enhancer of split 1; Transducin like enhancer of split 1 homolog of Drosophila E(sp1); Transducin like enhancer protein 1; transducin-like enhancer of split 1, homolog of Drosophila E(sp1)
    • Species :
    • Human
    • Rhesus Macaque
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TLE1-22H Recombinant Human TLE1 Protein, MYC/DDK-tagged HEK293T Myc/DDK
    Human TLE1-1051HCL Recombinant Human TLE1 293 Cell Lysate HEK293 N/A
    Rhesus Macaque TLE1-4728R Recombinant Rhesus monkey TLE1 Protein, His-tagged Mammalian Cell His

    TLE1 involved in several pathways and played different roles in them. We selected most pathways TLE1 participated on our site, such as Deactivation of the beta-catenin transactivating complex, Degradation of beta-catenin by the destruction complex, Delta-Notch Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Deactivation of the beta-catenin transactivating complex BCL9L; ASH2L; SOX9B; C; CTBP1; RBBP5; TLE4; TLE1; SOX7; TLE3B
    Degradation of beta-catenin by the destruction complex TLE3B; TLE4; AES; TLE1; CTBP2; FAM123B; CTBP1; TLE2; TLE3
    Delta-Notch Signaling Pathway TUBB3; MAGEA1; YY1A; TLE1; JAG2; HES6; ASCL1; ZFPM1; JAG1; HEY2
    Formation of the beta-catenin:TCF transactivating complex RBBP5; TLE1; BCL9L; ASH2L; TLE3; TLE4; TLE2; SMARCA4; PYGO1; CDC73
    NOTCH1 Intracellular Domain Regulates Transcription TLE4; TLE1; TUBB3; TLE3; HEY1; HEYL; TLE2; HEY2
    Notch-mediated HES/HEY network BGLAP; HEY1; GATA6; MYOD1; GATA1; ASCL1; MYB; TLE1; CTBP1; HES6
    Presenilin action in Notch and Wnt signaling AES; TLE1; KREMEN2; WIF1
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription ZCCHC12; IGF2BP1; CBY1; T; TLE1; TNIK; CDX1; SALL4; TLE4; CDX4

    TLE1 has several biochemical functions, for example, RNA polymerase II transcription corepressor activity, chromatin binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TLE1 itself. We selected most functions TLE1 had, and list some proteins which have the same functions with TLE1. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription corepressor activity SIN3AA; N4BP2L2; SIN3B; SIN3A; URI1; TBX15; TBX18; OLIG3; SOX3; ELANE
    chromatin binding JUB; HDAC3; ESR1; PARP1; TLE4; SAFB; CITED1; WHSC1; GATA5; SMC1A
    identical protein binding CALCA; PKD2; SEPT7; BNIP3; PARK2; KHDC1B; CD28; MCPH1; KCNIP2; KRTAP10-5
    protein binding SLC4A1; DUT; SLC7A11; FECH; CUL9; PTEN; ZKSCAN3; ZMYM4; KIR2DL4; TLR2
    transcription factor binding TRP53; E2F5; ZBTB49; HMGB1; SOX10; TAF12; NEUROD1; MLXIPL; FOXA3; FOS

    TLE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLE1.


    Endo, M; Su, L; et al. Activating transcription factor 2 in mesenchymal tumors. HUMAN PATHOLOGY 45:276-284(2014).
    Valente, AL; Tull, J; et al. Specificity of TLE1 Expression in Unclassified High-grade Sarcomas for the Diagnosis of Synovial Sarcoma. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY 21:408-413(2013).

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