|Official Full Name||transmembrane protease, serine 9|
|Background||Polyserase-1 is also known as TMPRSS9 (transmembrane serine proteinase-9), and polyserase protease 1. Polyserase1 was originally discovered in human liver as a mosaic serine proteinase with a type II transmembrane domain and three tandem repeats of serine proteinase domains. The domain structure of polyserase1 consists of a cytoplasmic domain, followed by a transmembrane domain, a "stem" region, an LDL receptor-like domain, and three serine proteinase domains. The third serine proteinase domain does not contain the canonical Gly-Asp-Ser-Gly-Gly residues found in the first two serase domains, and is not thought to be proteolytically active. Polyserase1 is found in greatest abundance in human liver, muscle, heart, placenta, and in fetal kidney and liver. Several human tumor cell lines also express significant amounts of polyserase1. Polyserase1 is a membrane associated protein, and the cleaved serase domains are thought to be retained on the cell surface by association with the propeptide domain, although the protein may also be found shed into conditioned culture media.|
|Synonyms||TMPRSS9; transmembrane protease, serine 9; transmembrane protease serine 9; polyserase 1; polyserase-1; polyserase-I; polyserine protease 1; transmembrane serine protease 9;|
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TMPRSS9 involved in several pathways and played different roles in them. We selected most pathways TMPRSS9 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TMPRSS9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
TMPRSS9 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by TMPRSS9 itself. We selected most functions TMPRSS9 had, and list some proteins which have the same functions with TMPRSS9. You can find most of the proteins on our site.
TMPRSS9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TMPRSS9 here. Most of them are supplied by our site. Hope this information will be useful for your research of TMPRSS9.