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TRAF2

  • Official Full Name

    TNF receptor-associated factor 2

  • Overview

    TNF receptor associated factor 2 (TRAF2) is thought to be a common signal transducer that associates with the cytoplasmic domains of the tumor necrosis factor receptor (TNFR) superfamily such as TNFR2, CD40 and CD30. TRAF2 indirectly associates with TNFR1
  • Synonyms

    TRAF2; TNF receptor-associated factor 2; TRAP3; E3 ubiquitin-protein ligase TRAF2; tumor necrosis factor type 2 receptor associated protein 3; tumor necrosis factor type 2 receptor-associated protein 3; TRAP; MGC:45012;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • HEK293
  • HEK293T
  • Insect cell
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TRAF2-1500H Recombinant Human TRAF2 Protein, GST-tagged Insect cell GST
Human TRAF2-31601TH Recombinant Human TRAF2, His-tagged His
Human TRAF2-824HCL Recombinant Human TRAF2 293 Cell Lysate HEK293 N/A
Human TRAF2-2248H-B Recombinant Human TRAF2 Protein Pre-coupled Magnetic Beads HEK293
Human TRAF2-1764HFL Recombinant Full Length Human TRAF2 Protein, C-Flag-tagged Mammalian cells Flag
Human TRAF2-2248H Recombinant Human TRAF2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TRAF2-17284M Recombinant Mouse TRAF2 Protein Mammalian Cell His
Mouse TRAF2-9556M-B Recombinant Mouse TRAF2 Protein Pre-coupled Magnetic Beads HEK293
Mouse TRAF2-9556M Recombinant Mouse TRAF2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Traf2-6617M Recombinant Mouse Traf2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque TRAF2-4931R Recombinant Rhesus monkey TRAF2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TRAF2-4745R Recombinant Rhesus Macaque TRAF2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TRAF2-4745R-B Recombinant Rhesus Macaque TRAF2 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TRAF2 Related Research Area
  • TRAF2 Related Signal Pathway

TRAF2 involved in several pathways and played different roles in them. We selected most pathways TRAF2 participated on our site, such as MAPK signaling pathway, NF-kappa B signaling pathway, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRAF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayMAP3K14;RPS6KA2;CASP3B;MAP3K7;RAP1A;RPS6KA6;MAPKAPK2;MAP2K2;AKT2L
NF-kappa B signaling pathwayICAM1;CD40;ZAP70;CCL4L1;IKBKB;CFLAR;LTBR;PTGS2;CARD11
Sphingolipid signaling pathwayPLCB1;TRADD;PIK3CA;GNAI3;LASS4;S1PR5;GNAI1;MAP3K5;DEGS2
Protein processing in endoplasmic reticulumUBE2G2;TUSC3;EIF2AK2;RPN2;UBE2E2;UBE2G1B;UBE2D4;P4HB;UBQLN1
ApoptosisMYC;PRKACA;CYCSB;IRF6;PTBP3;CAPN1B;AKT2L;DSG3;PPP3CB
Osteoclast differentiationMAP2K6;SFPI1;NOX1;CYLD;FCGR2B;LILRA4;TNFRSF11A;IFNAR2;FCGR2C
RIG-I-like receptor signaling pathwayIFNA5;IFNW1;Ifna15;TRADD;MAPK9;RIPK1;IKBKB;DDX3X;IFNA2
TNF signaling pathwayCCL20;FADD;MMP14;MAP2K7;CXCL10;PIK3CD;FAS;PIK3R1;CREB3L3
Adipocytokine signaling pathwayMAPK8;RXRB;RXRG;POMC;PTPN11;PRKAB1A;LEPR;SOCS3;RXRAA
Non-alcoholic fatty liver disease (NAFLD)UQCRB;ATF4;NDUFA8;XBP1;UQCRC2;SDHC;NR1H3;UQCRH;NDUFC2
Hepatitis CMAPK10;TRP53;EIF2AK2;CLDN4;NR1H3;CLDN18;IFNB1;IRF7;IL-8
Herpes simplex infectionCUL1A;IFNA7;PPP1CAA;IFNA21;SOCS3;EP300;CCL5;SRSF7A;MAPK10
Epstein-Barr virus infectionTRAF3;MAPK11;POLR3H;EIF2AK1;YWHAB;POLR1C;VIM;HLA-DPB1;POLR2L
Pathways in cancerTRAF2;BIRC8;PRKCA;WNT8B;Shh;BID;COL4A1;ITGA3;APC
Viral carcinogenesisTBPL2;HLA-B;HIST1H2BE;RAC1;CREB5;GTF2H2C;HIST2H4A;CCNE1;HIST1H4N
Small cell lung cancerPTEN;RXRA;LAMB4;BIRC7;RB1;LAMA3;TRAF2;LAMB2;PIK3R5

TRAF2 has several biochemical functions, for example, CD40 receptor binding, enzyme binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRAF2 itself. We selected most functions TRAF2 had, and list some proteins which have the same functions with TRAF2. You can find most of the proteins on our site.

Function Related Protein
CD40 receptor bindingTRAF2;CD40LG
enzyme bindingZFHX3;NOS1;DYM;PCBP2;ABCD1;HSPA2;YES1;ZNF346;CTNNBL1
identical protein bindingPRC1;DPY30;THG1L;ALS2CL;VPS41;BAX;CTSC;AHCY;TNF
ligase activityDZIP3;TTLL11;TRIM68;RNF216;RLIM;RNF43;MYLIPB;TRIM63;TMEM129
mitogen-activated protein kinase kinase kinase bindingMAPK8IP3;TCF3;MAP3K11;TRAF2;PPEF2;MAP2K1;CDC37;MAPK9;MAP4K2
protein bindingC2orf65;S1PR3;IFT43;OSBPL7;ZC3H14;DAZAP2;TTC39B;GEMIN8;DR1
protein complex bindingCCND1;WRN;CDKN1A;ATM;LEPRE1;TUB;UGT1A6B;ATG101;CALCA
protein kinase bindingDVL1;PAK2;BAD;PFKFB2;STAT3;DPYSL2;E2F1;RAB11FIP2;SHC3
protein phosphatase bindingCSF1R;TRP53;CTNNB1;ITGA1;PPP6R1;LCK;EIF2AK3;KAT2A;DRD1
signal transducer activityTAAR11;TAS2R109;V2RX1;GPR152;GNAO1B;GPR132B;PTGER2A;NFKBIB;PTGER4C
sphingolipid bindingS1PR1;TRAF2
thioesterase bindingRAC1;TRAF6;HAUS7;CALM2;CALM1;TRAF3;TRAF4;TRAF1;ARF6
tumor necrosis factor receptor bindingCASP8;FADD;TNFSF10L3;TRAF3;ERAP1;TNFSF8;TRAF2;TNFSF12;TRAF6
ubiquitin protein ligase bindingYWHAZ;HSPA9;ERLIN2;UBE2T;NPLOC4;PRKAR2B;RAD18;GSK3B;EGFR
ubiquitin-protein transferase activityRNF152;RNF144B;RNF168;BIRC5;NEDD4L;RC3H2;IRAK1;TRIM2;NHLRC1
zinc ion bindingDBF4;MT2A;SHANK3;SIAH1A;PGLYRP3;RUFY1;RNF40;NPLOC4;SIVA1

TRAF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRAF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRAF2.

BIRC2; BIRC3

  • Q&As
  • Reviews

Q&As (7)

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What are the mechanisms by which TRAF2 modulates stress response pathways in cells? 11/18/2022

TRAF2 modulates cellular stress response pathways, helping cells adapt to environmental and internal stressors.

What role does TRAF2 play in regulating apoptosis and cell survival signals? 10/03/2022

TRAF2 plays a crucial role in cell survival and apoptosis, balancing signals to determine cell fate.

How does TRAF2 mediate signal transduction in the TNF receptor pathway, particularly in inflammatory responses? 06/21/2020

TRAF2 is a key mediator in the TNF receptor signaling pathway, regulating inflammatory responses and cytokine production.

How does TRAF2 influence the development and progression of cancer, especially in terms of tumor cell survival and proliferation? 05/06/2019

TRAF2 affects cancer progression, influencing tumor cell survival, proliferation, and resistance to apoptosis.

How does TRAF2 contribute to immune system regulation, particularly in adaptive immune responses? 11/20/2018

TRAF2 is involved in immune system regulation, affecting both innate and adaptive immune responses.

How do alterations in TRAF2 expression or function affect the body's response to infections and pathogens? 09/19/2018

Changes in TRAF2 function impact the body's ability to respond to infections, affecting immune defense mechanisms.

What is the impact of TRAF2 dysregulation on the pathogenesis of autoimmune diseases? 07/11/2018

Dysregulation of TRAF2 can contribute to the development of autoimmune diseases by altering immune responses.

Customer Reviews (3)

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Reviews
11/11/2022

    Efficient peptide synthesis, accelerates our peptide-focused projects.

    10/07/2021

      Reliable antibody validation, vital for our experimental success.

      02/21/2021

        Accurate mass spectrometry analysis, critical for our proteomics studies.

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