TRAF2
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Official Full Name
TNF receptor-associated factor 2
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Overview
TNF receptor associated factor 2 (TRAF2) is thought to be a common signal transducer that associates with the cytoplasmic domains of the tumor necrosis factor receptor (TNFR) superfamily such as TNFR2, CD40 and CD30. TRAF2 indirectly associates with TNFR1 -
Synonyms
TRAF2; TNF receptor-associated factor 2; TRAP3; E3 ubiquitin-protein ligase TRAF2; tumor necrosis factor type 2 receptor associated protein 3; tumor necrosis factor type 2 receptor-associated protein 3; TRAP; MGC:45012;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- HEK293
- HEK293T
- Insect cell
- Mammalian Cell
- Mammalian cells
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- TRAF2 Related Research Area
- TRAF2 Related Signal Pathway
TRAF2 involved in several pathways and played different roles in them. We selected most pathways TRAF2 participated on our site, such as MAPK signaling pathway, NF-kappa B signaling pathway, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRAF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | GNG12A;MKNK2;FOS;FASLG;FGF20B;CACNG6A;LRRK2;MAP2K3;FGFR3 |
| NF-kappa B signaling pathway | CCL4L2;TLR4;LAT;SYK;GM10591;CCL19;IL1B;IKBKB;NFKB2 |
| Sphingolipid signaling pathway | MAP3K5;PLCB4;MAPK11;RAC2;PIK3R2;SMPD2;PPP2R5B;PPP2R2A;SPHK2 |
| Protein processing in endoplasmic reticulum | P4HB;MAPK9;UBQLN1;GSBP9;CCDC102A;LMAN1L;ATXN3L;AMFR;MAP3K5 |
| Apoptosis | GAS2;PPP3R2;IKBKB;BOKA;PRKACBB;CAPN1B;CASP6L1;CAPN1A;DFFA |
| Osteoclast differentiation | LILRB1;SQSTM1;GAB2;STAT2;SPI1;PPP3CA;FCGR1;CSF1R;SIRP-BETA |
| RIG-I-like receptor signaling pathway | CXCL10;IFNB1;TRAF2;RNF125;IL-8;Ifna15;TRAF6;TNF;MAP3K7 |
| TNF signaling pathway | MAP3K14;TNFRSF1A;MAPK11;RPS6KA5;LIF;CFLAR;PIK3R5;MAP2K1;TRADD |
| Adipocytokine signaling pathway | G6PC;SLC2A1A;SOCS3B;STK11;PCK1;ACSL4A;RXRB;ACSL5;NFKBIAB |
| Non-alcoholic fatty liver disease (NAFLD) | NDUFAB1;NDUFA4;COX7A2L;NDUFS6;NDUFS7;UQCRC2;BID;UQCRQ;NR1H3 |
| Hepatitis C | EIF3E;OAS2;KRAS;PIK3CD;RIPK1;CLDN3;IFNA5;TP53;OAS1A |
| Herpes simplex infection | IFNA13;EIF2AK1;NFKBIB;EEF1DA;NFKBIA;ARNTL;IRF3;TRAF1;MHC1UEA |
| Epstein-Barr virus infection | PSMD11;POLR2L;HLA-C;PSMD13;PIK3CG;POLR3GL;MAP2K6;STAT3;IRF3 |
| Pathways in cancer | CCNE1;BCL2;FGF3;LAMC1;GNAS;RXRB;MAPK3;TPM3;ITGB1 |
| Viral carcinogenesis | YWHAG;GTF2H2C;TRAF2;H2-Q10;HIST1H2BL;HLA-G;EGR3;HIST1H2BC;GTF2H4 |
| Small cell lung cancer | ITGB1;RXRB;MAX;PIK3R2;IKBKB;BIRC2;IKBKG;TRAF6;TRAF5 |
TRAF2 has several biochemical functions, for example, CD40 receptor binding, enzyme binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRAF2 itself. We selected most functions TRAF2 had, and list some proteins which have the same functions with TRAF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| CD40 receptor binding | TRAF2;CD40LG |
| enzyme binding | SLC18A1;UGT1A1;KDM4C;UBE4B;AXIN2;ARRB2;PAWR;HSPA6;PUS7 |
| identical protein binding | COL7A1;BCL2;ZNF3;ATG101;LDHB;DIAP1;SMAD1;MPST;MVK |
| ligase activity | UNKL;TTLL6;HLTF;ITCHA;UBE2IB;TRIM17;MID1;ZNRF2B;MKRN2 |
| mitogen-activated protein kinase kinase kinase binding | MAP2K1;CDC42;DUSP19;MAPK1;MAPK8IP3;MAP3K11;STK38;TCF3;TRAF6 |
| protein binding | ZNF239;KLKB1;WNT11;CCDC121;APOBEC3F;COPS7B;TPRKB;PARP4;HOXA10 |
| protein complex binding | GIT2;LZTFL1;HADHA;ATP6V1B1;FGFR1;AP2A2;ABI2;PRKACA;HSPD1 |
| protein kinase binding | CAV2;CAV1;CRY1;MAPT;TBC1D14;BORA;KIF11;KIF14;CACNB2 |
| protein phosphatase binding | TRAF2;CDKN1B;SNX3;CSF1R;JAK1;ERBB2;ITGA1;SKAP1;SHOC2 |
| signal transducer activity | CCR1L1;TICAM1;GPR177;OLFR151;GPR30;PTGER2A;FPR-RS4;OLFR150;V2RH14 |
| sphingolipid binding | S1PR1;TRAF2 |
| thioesterase binding | CALM1;CALM3;TRAF1;TRAF2;HAUS7;ARF6;CALM2;RAC1;TRAF6 |
| tumor necrosis factor receptor binding | EDA;TNFSF15;TNFSF10L4;BRE;TNFSF12;TNFSF10L3;TNFB;TNFSF13;TRAF1 |
| ubiquitin protein ligase binding | BAG4;PRKACA;HSPA1B;UBE2G2;PRKACB;GPR19;CASP10;UBE2NA;PML |
| ubiquitin-protein transferase activity | DZIP3;RNF146;MUL1A;ITCHA;FBXO7;HECTD3;FBXO40.1;TRIM69;MARCH1 |
| zinc ion binding | FBXO30;ADAMTS10;NANOS3;DHH;ING2;APOBEC3D;ZEB1;PGGT1B;APOBEC3B |
TRAF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRAF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRAF2.
BIRC2; BIRC3
- Q&As
- Reviews
Q&As (7)
Ask a questionTRAF2 modulates cellular stress response pathways, helping cells adapt to environmental and internal stressors.
TRAF2 plays a crucial role in cell survival and apoptosis, balancing signals to determine cell fate.
TRAF2 is a key mediator in the TNF receptor signaling pathway, regulating inflammatory responses and cytokine production.
TRAF2 affects cancer progression, influencing tumor cell survival, proliferation, and resistance to apoptosis.
TRAF2 is involved in immune system regulation, affecting both innate and adaptive immune responses.
Changes in TRAF2 function impact the body's ability to respond to infections, affecting immune defense mechanisms.
Dysregulation of TRAF2 can contribute to the development of autoimmune diseases by altering immune responses.
Customer Reviews (3)
Write a reviewEfficient peptide synthesis, accelerates our peptide-focused projects.
Reliable antibody validation, vital for our experimental success.
Accurate mass spectrometry analysis, critical for our proteomics studies.
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