traf2
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  • Official Full Name
  • TNF receptor-associated factor 2
  • Background
  • TNF receptor associated factor 2 (TRAF2) is thought to be a common signal transducer that associates with the cytoplasmic domains of the tumor necrosis factor receptor (TNFR) superfamily such as TNFR2, CD40 and CD30. TRAF2 indirectly associates with TNFR1
  • Synonyms
  • TRAF2; TNF receptor-associated factor 2; TRAP3; E3 ubiquitin-protein ligase TRAF2; tumor necrosis factor type 2 receptor associated protein 3; tumor necrosis factor type 2 receptor-associated protein 3; TRAP; MGC:45012
Cat.#:TRAF2-1500HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human TRAF2 Protein, GST-tagged
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Cat.#:TRAF2-31601THTag:His
Source (Host):Species:Human
Product nameRecombinant Human TRAF2, His-tagged
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Cat.#:TRAF2-17284MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TRAF2 Protein
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Cat.#:TRAF2-4931RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TRAF2 Protein, His-tagged
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Cat.#:TRAF2-824HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human TRAF2 293 Cell Lysate
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Involved Pathway

TRAF2 involved in several pathways and played different roles in them. We selected most pathways TRAF2 participated on our site, such as MAPK signaling pathway, NF-kappa B signaling pathway, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRAF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAPK8IP2; IL1B; MAP3K1; FGF7; CD14; FGF12; CACNA1B; TRAF6; RASGRF2B; TGFB3
NF-kappa B signaling pathway
MAP3K7IP3; SYK; TRAF5; IKBKG; TNFSF13B; CCL19; IL1R1; IL-8; ICAM1; ERC1
Sphingolipid signaling pathway
PIK3R5; MAPK12; CERS2; BID; TRP53; PPP2R3C; PRKCZ; SGPP2; SPHK1; TNF
Protein processing in endoplasmic reticulum
CAPN1A; LMAN2; MARCH6; RPN2; EDEM3; MAN1C1; FBXO6; TUSC3; BAG2; CRYAB
Apoptosis
IRAK2; PPP3CB; DBNL; BIDA; IL1B; PPP3CA; BCAP31; CAPN1B; HIST1H1A; CASP12
Osteoclast differentiation
GRB2; TGFB2; FOS; CYBB; AKT2; FCGR3; FHL2; LILRB3; FCGR1A; NFKBIA
RIG-I-like receptor signaling pathway
IRF3; TRAF3; MAP3K1; TRAF2; NLRX1; MAPK11; IFNA12; RIPK1L; Ifna11; CASP8
TNF signaling pathway
CCL20; BCL3; ATF4; MAPK13; LTA; RPS6KA5; MMP9; FADD; MAP3K5; TNFRSF1B
Adipocytokine signaling pathway
MAPK8A; PRKAA1; PRKAG1; PRKAB1; IRS1; PRKAB1B; RXRBA; ADIPOR2; IRS4; ACSL3B
Non-alcoholic fatty liver disease (NAFLD)
GSK3B; PKLR; PRKAG3; LEP; ADIPOQ; Fasl; INS; UQCRQ; CDC42; PPARA
Hepatitis C
CLDN1; IFNA4; DDX58; IRF9; PPP2CB; NFKB1; PIK3CG; SOCS3; BRAF; CLDN11
Herpes simplex infection
IFNB1; TP53; DAXX; HNRPK; SRPK1A; IFNA6; IRF9; OAS3; EIF2AK1; MAPK10
Epstein-Barr virus infection
PIK3R2; HLA-A; POLR3B; NFKBIE; TAB2; NFKBIA; PSMC1; SND1; POLR2I; POLR2H
Pathways in cancer
STAT5B; LPAR3; FGF4; WNT8A; WNT3; CKS2; GNAI3; RHOA; FN1; PLCB1
Viral carcinogenesis
NRAS; TBPL1; HRAS; RBL1; PKM2; HIST1H2BJ; YWHAZ; NFKBIA; YWHAG; PIK3CD
Small cell lung cancer
LAMA4; BIRC2; PTK2; RXRG; CYCS; NFKB1; LAMC1; MAX; PIK3CB; FN1

Protein Function

TRAF2 has several biochemical functions, for example, CD40 receptor binding, enzyme binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRAF2 itself. We selected most functions TRAF2 had, and list some proteins which have the same functions with TRAF2. You can find most of the proteins on our site.
Function
Related Protein
Function CD40 receptor binding
Related Protein CD40LG; TRAF2
Function enzyme binding
Related Protein HOXA9; THRB; HAND1; UGT1A1; YES1; HIST1H2AD; NOS1; TOP2A; RCOR1; CYP2C19
Function identical protein binding
Related Protein DACT3; PLDN; PKD2L1; HAND2; SMAD4; TTR; HAPLN2; AHI1; SRI; GRB7
Function ligase activity
Related Protein TTLL5; UBR5; FPGS; RNF40; TTLL6; PDZRN3; ZSWIM2; HECW1B; HECTD2; RNF2
Function mitogen-activated protein kinase kinase kinase binding
Related Protein MAP3K11; PPEF2; CDC42; TRAF2; TRAF6; MAPK8IP3; MAPK9; STK38; MAPK1; DUSP19
Function protein binding
Related Protein COLQ; ANKRD27; NIF3L1; RCHY1; FGF2; EDDM3B; SH3YL1; NUP153; MATN4; SLC7A11
Function protein complex binding
Related Protein ATP6V0D1; PDX1; NSF; CDK5RAP2; ERCC6; TG; CDK5RAP1; FADD; RAN; HSPD1
Function protein kinase binding
Related Protein SPRED1; PAX6; CALM; CCNB1; NGFRAP1; GATA4; RCC2; NEFH; CDC25C; KIF13B
Function protein phosphatase binding
Related Protein MAP3K5; MAPK14; ERBB2; FLT4; EGFR; PPP1R3G; PIK3R1; ROS1; GNB2L1; ANAPC7
Function signal transducer activity
Related Protein PLEKHG5; ILK; OLFCJ1; GNAV1; TAAR14I; TAS2R126; OLFR491; FZD1; TMTOPS3B; AIP
Function sphingolipid binding
Related Protein TRAF2; S1PR1
Function thioesterase binding
Related Protein TRAF6; CALM3; CALM2; ADRA2A; TRAF1; TRAF3; RAC1; HAUS7; TRAF4; CALM1
Function tumor necrosis factor receptor binding
Related Protein TNFSF13B; EDA; TNFSF9; TRAF1; TNFSF10L; BRE; CD40LG; FADD; CD70; TNFSF10
Function ubiquitin protein ligase binding
Related Protein CUL4B; GABARAPL2; UBE2J2; SCAMP3; GLMN; LYN; MAGEA2B; TXNIP; GRIK2; CKB
Function ubiquitin-protein transferase activity
Related Protein FBXL7; TRAF5; MIB1; STUB1; UBE2Q2; UHRF1; RNF213; RNF144AB; BRCA1; TRIM33
Function zinc ion binding
Related Protein NANOS2; CA15B; XIAP; ZNF257; RNF138; NR1D2B; TRIM21; MUL1A; XRN2; MICALL1

Interacting Protein

TRAF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRAF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRAF2.
BIRC2; BIRC3