traf2
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  • Official Full Name
  • TNF receptor-associated factor 2
  • Background
  • TNF receptor associated factor 2 (TRAF2) is thought to be a common signal transducer that associates with the cytoplasmic domains of the tumor necrosis factor receptor (TNFR) superfamily such as TNFR2, CD40 and CD30. TRAF2 indirectly associates with TNFR1
  • Synonyms
  • TRAF2; TNF receptor-associated factor 2; TRAP3; E3 ubiquitin-protein ligase TRAF2; tumor necrosis factor type 2 receptor associated protein 3; tumor necrosis factor type 2 receptor-associated protein 3; TRAP; MGC:45012
Cat.#:TRAF2-1500HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human TRAF2 Protein, GST-tagged
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Cat.#:TRAF2-31601THTag:His
Source (Host):Species:Human
Product nameRecombinant Human TRAF2, His-tagged
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Cat.#:TRAF2-17284MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TRAF2 Protein
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Cat.#:TRAF2-4931RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TRAF2 Protein, His-tagged
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Cat.#:TRAF2-824HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TRAF2 293 Cell Lysate
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Involved Pathway

TRAF2 involved in several pathways and played different roles in them. We selected most pathways TRAF2 participated on our site, such as MAPK signaling pathway, NF-kappa B signaling pathway, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRAF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAPK12B; FGF19; CACNA1SA; CACNA1D; PPM1AB; NLK1; CACNA2D2; MAPK7; GADD45G; RPS6KA6
NF-kappa B signaling pathway
Bcl2a1b; BCL10; GADD45B; IKBKB; PIAS4; LBP; BCL2A1; LRDD; IL-8; BTK
Sphingolipid signaling pathway
MAPK1; LASS4; GNAI1; PPP2R3C; BID; SPHK2; PDPK1; GAB2; ROCK1; PPP2R5D
Protein processing in endoplasmic reticulum
UBE4B; SYVN1; UGGT1; HSPA4L; NGLY1; BAG1; UBE2D1B; SELS; DNAJB1; MAN1A1
Apoptosis
CASP10; CRADD; DFFA; HMGB2A; LMNB1; BNIP3L; TRP53; PRKACA; DIABLOB; RNF8
Osteoclast differentiation
PPP3R2; BTK; CYLD; MAPK9; IL1A; AKT1; TGFB2; LILRB5; TGFBR2; ITGB3
RIG-I-like receptor signaling pathway
CXCL10; MAPK10; TRAF2; MAPK8; DDX3X; NFKBIB; IFNA4; Ifna15; TNF; MAPK12B
TNF signaling pathway
MMP14; IL15; ICAM1; TRADD; AKT2; BIRC3; MAP3K14; PIK3CG; MAP3K7; IL6
Adipocytokine signaling pathway
RELA; AKT1; ADIPOR1B; AKT2L; PTPN11A; RXRGB; MAPK8B; NFKBIA; PRKAA1; CAMKK2
Non-alcoholic fatty liver disease (NAFLD)
NFKB1; DDIT3; EIF2AK3; Casp3; NDUFS8; GSK3B; NDUFV1; NDUFAB1; NDUFA1; UQCRC1
Hepatitis C
ARAF; PPP2R2A; MAPK1; PPARA; IKBKB; CLDN3; TP53; IFNB1; PPP2R2C; IRF7
Herpes simplex infection
IKBKE; SRSF5; MAP3K7; ARNTL; BLB2; TBPL2; PPP1CAB; IFNA8; CD74A; MYD88
Epstein-Barr virus infection
PRKACG; PSMC3; HLA-A; POLR2E; SHFM1; POLR3E; POLR3K; POLR3GL; MAP3K7; IKBKB
Pathways in cancer
Ar; GNB2; CBL; CDH1; RELA; PRKCB; Shh; PIK3R3; VEGFB; PIK3CD
Viral carcinogenesis
IRF3; TRADD; TP53; HDAC11; CCND2; SND1; HDAC1; SP100; PIK3CG; MRPS18B
Small cell lung cancer
TRP53; CCNE1; IKBKB; LAMA4; BIRC7; COL4A1; RARB; PIK3R1; TRAF2; CYCS

Protein Function

TRAF2 has several biochemical functions, for example, CD40 receptor binding, enzyme binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRAF2 itself. We selected most functions TRAF2 had, and list some proteins which have the same functions with TRAF2. You can find most of the proteins on our site.
Function
Related Protein
Function CD40 receptor binding
Related Protein CD40LG; TRAF2
Function enzyme binding
Related Protein PEX7; HOXA9; APP; LUC7L2; RCOR2; CBX3; KAT8; RCOR3; TOP2B; PARK7
Function identical protein binding
Related Protein GCG; KHDRBS1; LCK; WRNIP1; HCN4; SMN1; PNMA5; SHANK3; CBS; GLUL
Function ligase activity
Related Protein UBE2KB; RNF185; MYLIPA; MYLIPB; CTPS1A; TRAF3; MID1; PRPF19; SHPRH; SHRPRBCK1R
Function mitogen-activated protein kinase kinase kinase binding
Related Protein MAP2K1; MAPK8IP3; TRAF6; PPEF2; TCF3; STK38; MAPK9; MAP3K11; DUSP19; MAPK1
Function protein binding
Related Protein CASKIN1; TFPT; PNPT1; TAX1BP3; TTR; STXBP1; VPS18; C9orf116; FGB; CDIPT
Function protein complex binding
Related Protein PPFIA2; EPHB1; GIT1; UGT1A6B; SHARPIN; RNF40; PTPRF; ADM2; C8A; C8G
Function protein kinase binding
Related Protein PIWIL1; ITGB1BP1; SPDYE2; MAP3K1; IKBKB; RB1CC1; CACNB4; CADPS; EPHA1; CDKN2D
Function protein phosphatase binding
Related Protein RPA3; MAP2K7; STAT6; VCAN; DRD1; SNX3; CDC27; PPARG; Itga10&Itgb1; PPP6R3
Function signal transducer activity
Related Protein GPR126; PLCL2; OR115-6; ADRB3B; GNB1A; GNG12A; O3far1; TAS2R140; GPR186; LPAR2B
Function sphingolipid binding
Related Protein TRAF2; S1PR1
Function thioesterase binding
Related Protein RAC1; TRAF2; ARF6; ADRA2A; CDC42; TRAF1; TRAF6; CALM2; CALM3; TRAF3
Function tumor necrosis factor receptor binding
Related Protein TNF; CD40LG; TNFSF13; TRAF4; CASP8; CD70; TNFSF9; TRIM37; TNFSF13B; TNFSF8
Function ubiquitin protein ligase binding
Related Protein PML; GPI; PINK1; ATP6V0C; TXNIP; BCL2; DBT; TANK; XRCC5; FZD5
Function ubiquitin-protein transferase activity
Related Protein UBR5; UBE2D2A; PRP19; RNF130; MYLIP; CBLL1; TRIM5; TRIM24; RNF168; ZFP91
Function zinc ion binding
Related Protein KDM4A; RNF13; RARAB; FBXL19; GLI2; AJUBA; RBM14B; MATR3L; LONRF3; S100A5

Interacting Protein

TRAF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRAF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRAF2.
BIRC2; BIRC3