TRIM11

  • Official Full Name

    tripartite motif containing 11

  • Overview

    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. [provided by RefSeq, Jul 2008]

  • Synonyms

    TRIM11;tripartite motif containing 11;BIA1;RNF92;E3 ubiquitin-protein ligase TRIM11;RING finger protein 92;tripartite motif-containing 11;tripartite motif-containing protein 11

Recombinant Proteins

  • Human
  • Mouse
  • Rhesus macaque
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • SUMO
  • Avi
  • Fc
  • DDK
  • Myc
  • Flag

    Involved Pathway

    TRIM11 involved in several pathways and played different roles in them. We selected most pathways TRIM11 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System RNF6,KLRG1,KIF5B,CTSH,LILRA3,FBXO3,CTLA4,UBE2V1,DYNC1I1,SIGLEC11
    Proteasome degradation RNF4,RNF123,RNF34,RNF182,PJA2,DZIP3,SPSB1,HUWE1,FBXO44,ASB13
    presentation FBXO27,SPSB4,RNF34,NPEPPS,ATG7,LRRC41,RNF111,KLHL21,RNF25,STUB1
    Class I MHC mediated antigen processing &amp ARIH2,UBR2,MKRN1,UBR1,UBE2E3,TPP2,PJA2,UBE2V2,FBXO27,B2ML
    Immune System TRIM10,AMICA1,TANK,TRIM68,FCN3,NCKAP1,CD200R3,CD200R2,CASPB,DCTN6
    Antigen processing: Ubiquitination &amp ARIH2,BLMH,RNF4,ASB7,SPSB2,FBXO27,TRAF7,ASB4,RNF220,RNF14

    Protein Function

    TRIM11 has several biochemical functions, for example, ligase activity,protein binding,protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM11 itself. We selected most functions TRIM11 had, and list some proteins which have the same functions with TRIM11. You can find most of the proteins on our site.

    Function Related Protein
    transcription factor binding SP1,CDK9,CDKN2A,SORBS3,POU5F1,ATOH8,CCND1,NAAA,HAND1,DNAJA3
    ubiquitin protein ligase activity RNF111,TRAIP,UBE2KA,ARIH2,UBE2W,PDZD4,UBE2N,UHRF2,NHLRC1,UBE2J2
    zinc ion binding ZNF84,ZMAT5,SP140L,PDLIM2,RXRGA,HLTF,ADAM25,MORC3,TRIM22,WHSC1L1
    protein domain specific binding MECP2,HIST1H4H,DDX6,FOXH1,HIST1H4B,ATN1,AKAP5,STX1B,LIN7B,YWHAH
    protein binding OAZ2,FERMT2,CPNE3,OSTC,MEN1,RPL28,LCP2,TMED9,PRNP,RAD18
    ligase activity RNF19A,MUL1A,MEX3C,RNF135,TTLL4,NSMCE2,XIAP,MYLIPB,DTX3,SH3RF2

    Interacting Protein

    TRIM11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM11 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM11.

    MED15;UBA1;UBE2N;UBE2V1;PAX6;yngF;gpsA;RNF126;TRIM35;Smad6

    Resources

    References

    • Di, K; Linskey, ME; et al. TRIM11 is overexpressed in high-grade gliomas and promotes proliferation, invasion, migration and glial tumor growth. ONCOGENE 32:5038-5047(2013).
    • Lee, Y; Song, B; et al. TRIM11 Negatively Regulates IFN beta Production and Antiviral Activity by Targeting TBK1. PLOS ONE 8:-(2013).

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