TRIM50

  • Official Full Name

    tripartite motif containing 50

  • Synonyms

    TRIM50;tripartite motif containing 50;TRIM50A, tripartite motif containing 50 , tripartite motif containing 50A;E3 ubiquitin-protein ligase TRIM50;FLJ32804;E3 ubiquitin ligase;tripartite motif protein 50;tripartite motif-containing 50;tripartite

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E. coli
  • His
  • DDK
  • Myc
  • Avi
  • Fc
  • GST

    Involved Pathway

    TRIM50 involved in several pathways and played different roles in them. We selected most pathways TRIM50 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Immune System UBE2J2,TNFSF13B,KLRB1A,SIGLEC12,KIF2C,Mill2,HAVCR2,GBP2,MX2,IFIT14
    Antigen processing: Ubiquitination &amp ASB7,UBE2U,RNF19B,RNF4,CMTM2A,TRIM9,RNF138,LRRC41,UBE2L6,HECTD3
    presentation UBR2,UBR1,WWP1,VPRBP,ASB9,UBE2U,GAN,FBXO44,RNF6,UBE2J2
    Class I MHC mediated antigen processing &amp RNF14,RNF220,RNF111,LRSAM1,RNF6,RNF138,HECTD3,MKRN1,ERAP1,ASB18
    Adaptive Immune System CDKN1B,HBEGF,OSCAR,IGKV1-5,ASB2,IGKC,HCST,RNF4,KIF22,TRIM63
    Proteasome degradation LRR1,FBXO3,ASB3,LRRC41,UBE2L6,RNF14,ASB8,UCHL3,FBXO44,TRIM41

    Protein Function

    TRIM50 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity,coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM50 itself. We selected most functions TRIM50 had, and list some proteins which have the same functions with TRIM50. You can find most of the proteins on our site.

    Function Related Protein
    protein-glycine ligase activity, initiating MGRN1A,MARCH4,TRIM71,MARCH6,ZNRF3,UBE2IB,RFWD2,RNF187,MARCH9,UBR1
    protein-glycine ligase activity, elongating SIAH2L,MGRN1A,SHRPRBCK1R,RNF144AB,SIAH1A,RC3H2,TRIM41,MARCH6,ARIH1L,RNF169
    coenzyme F420-0 gamma-glutamyl ligase activity RAG1,RNF169,MARCH6,UBE2IB,RC3H2,MARCH11,RNF180,MUL1A,HECW2,RNF144AB
    ligase activity HERC4,TRIM56,MARCH8,TRIM63,MIB1,PELI3,MARCH6,UBE2I,TRIML1,ZNRF2B
    tubulin-glycine ligase activity RNF169,MARCH5L,ZNRF2B,RNF180,NEURL3,RNF144AA,UBR1,UBE2IA,ARIH1L,UBE2IB
    ribosomal S6-glutamic acid ligase activity MARCH6,SIAH2L,ZNRF3,ARIH1L,RC3H2,RAG1,RNF144AB,TMEM129,MYLIPB,MARCH11
    protein binding RUNX1T1,SPRR3,CANX,SEPT1,Car8,WASF2,ATL1,RSPO2,RAB11FIP2,FKBP2
    coenzyme F420-2 alpha-glutamyl ligase activity MGRN1A,MARCH6,UBE2IA,RNF149,NEURL3,ZNRF3,RNF187,ZNRF2B,ARIH1L,UBR1
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity MARCH11,MUL1A,RNF144AA,DTX1,UBR1,ITCHA,RNF149,TMEM129,MYLIPA,NEURL1B

    Interacting Protein

    TRIM50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM50 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM50.

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