TRIM50

  • Official Full Name

    tripartite motif containing 50

  • Synonyms

    TRIM50;tripartite motif containing 50;TRIM50A, tripartite motif containing 50 , tripartite motif containing 50A;E3 ubiquitin-protein ligase TRIM50;FLJ32804;E3 ubiquitin ligase;tripartite motif protein 50;tripartite motif-containing 50;tripartite

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E. coli
  • His
  • DDK
  • Myc
  • Avi
  • Fc
  • GST

    Involved Pathway

    TRIM50 involved in several pathways and played different roles in them. We selected most pathways TRIM50 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Proteasome degradation PJA2,ARIH2,TRAF7,SPSB2,FBXO27,TRIM63,UBA5,DZIP3,RNF25,VPRBP
    Class I MHC mediated antigen processing &amp KLHL21,SPSB2,RNF138,UBE2J2,ERAP2,SH3RF1,DTX3L,RNF34,RNF14,CTSL1
    Adaptive Immune System ARIH2,CLEC2B,CD300A,LTN1,UBR1,SRMS,CYBB,ERAP2,DYNC1LI2,HBEGF
    presentation SPSB4,PJA1,ATG7,KLHL20,ERAP2,ASB4,FBXO17,UBE2L6,ASB6,RNF123
    Immune System DEFA5,WIPF2,DEFA6,SIGLEC9,RACGAP1,MKRN1,EIF4G2,TRIM11,PPAPDC1A,KLHL21
    Antigen processing: Ubiquitination &amp RNF34,LRSAM1,UBE2F,SPSB2,HECTD3,RNF14,TPP2,ASB4,ASB10,TRIM69

    Protein Function

    TRIM50 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity,coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM50 itself. We selected most functions TRIM50 had, and list some proteins which have the same functions with TRIM50. You can find most of the proteins on our site.

    Function Related Protein
    ribosomal S6-glutamic acid ligase activity TRIM71,RNF187,RFWD2,ARIH1L,RNF169,RNF144AA,ITCHA,TRIM41,TMEM129,RNF149
    ligase activity HERC2,RNF25,SIAH1,SMURF2,TRIM58,UBE1Y1,RNF139,RFWD2,HERC4,MARCH1
    coenzyme F420-0 gamma-glutamyl ligase activity MGRN1A,UBE2IB,RC3H2,ARIH1L,NEURL3,MARCH6,HERC2,MARCH11,ZNRF2B,RNF169
    protein-glycine ligase activity G2E3,NEURL1B,MYLIPA,ARIH1L,MARCH4,MARCH6,NEURL3,RNF144AA,LTN1,SIAH1A
    coenzyme F420-2 alpha-glutamyl ligase activity RFWD2,ITCHA,ARIH1L,HERC2,MUL1A,RNF187,ZNRF2B,TMEM129,HECW2,MARCH5L
    tubulin-glutamic acid ligase activity RC3H2,SIAH1A,RNF187,ZNRF2B,TMEM129,UBE2IB,MYLIPB,MARCH5L,UBE2IA,MARCH4
    tubulin-glycine ligase activity UBE2IA,MARCH5L,RNF169,ZNRF2B,RNF180,RFWD2,ITCHA,MARCH11,RNF144AB,SHRPRBCK1R
    protein binding SNF8,TBC1D10A,UBE2W,KCNMA1,CBFB,SEMA4C,GGN,STAP1,IL1R2,FKBP8
    protein-glutamic acid ligase activity MARCH6,MUL1A,RC3H2,RNF144AA,SIAH1A,DTX1,TMEM129,RNF169,TRIM41,MARCH11

    Interacting Protein

    TRIM50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM50 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM50.

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