TRIM50

  • Official Full Name

    tripartite motif containing 50

  • Synonyms

    TRIM50;tripartite motif containing 50;TRIM50A, tripartite motif containing 50 , tripartite motif containing 50A;E3 ubiquitin-protein ligase TRIM50;FLJ32804;E3 ubiquitin ligase;tripartite motif protein 50;tripartite motif-containing 50;tripartite

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E. coli
  • His
  • DDK
  • Myc
  • Avi
  • Fc
  • GST

    Involved Pathway

    TRIM50 involved in several pathways and played different roles in them. We selected most pathways TRIM50 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Class I MHC mediated antigen processing &amp HECTD3,ATG7,FCGR1B,CTSL2,UBE2V2,RNF19B,MKRN1,CD207,PJA1,DZIP3
    Proteasome degradation ASB17,DTX3L,DZIP3,RNF6,IWS1,UBE2U,TRIM63,SPSB4,UBR1,TRIM69
    Antigen processing: Ubiquitination &amp RNF4,TRIM63,WWP1,ASB18,UBE2F,ATG7,STUB1,UBE2E3,TPP2,FBXO17
    Immune System TRIM38,ISG20,TRIM41,LTN1,CD200R1,UBE2E3,CLEC2D,NCR3LG1,AP1S1,EIF4G2A
    Adaptive Immune System CD300LH,UBE2E3,ITK,LILRA1,DCTN1,UBR1,RNF144B,LRR1,FBXO3,KLC3
    presentation TRIM39,SEC23A,UBA5,SEC24A,SEC61B,TRIM69,ASB4,SH3RF1,CYBA,ASB6

    Protein Function

    TRIM50 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity,coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM50 itself. We selected most functions TRIM50 had, and list some proteins which have the same functions with TRIM50. You can find most of the proteins on our site.

    Function Related Protein
    zinc ion binding NR1D4A,ZCCHC7,CNBP,MUL1,ZCCHC16,RBM10,TCEA3,PHF20L1,ZDHHC15B,JUB
    protein-glycine ligase activity, initiating HERC2,RNF144AA,ITCHA,ZNRF2B,MGRN1A,NEURL3,MYLIPA,RNF180,MARCH6,MARCH11
    coenzyme F420-0 gamma-glutamyl ligase activity TMEM129,SHRPRBCK1R,ITCHA,HECW2,RNF180,MARCH9,LTN1,SIAH2L,RFWD2,TRIM41
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ARIH1L,MARCH6,RNF169,RNF144AA,SHRPRBCK1R,DTX1,UBE2IB,ZNRF2B,HERC2,NEURL3
    ligase activity MDM2,RTCD1,RNF216,TTLL9,PIAS4,CBLL1,XIAP,RNF125,TRAF2,TRIM11
    tubulin-glutamic acid ligase activity RNF180,G2E3,MYLIPB,UBR1,LTN1,ARIH1L,RNF149,RNF144AA,MGRN1A,HECW2
    protein binding HS3ST5,UGP2,ATP6V0A2,DAPK1,HMBOX1,ITGB3BP,KRTAP10-5,DBNL,KLRC1,LRRIQ3
    tubulin-glycine ligase activity RNF187,TRIM71,ZNRF2B,SIAH1A,LTN1,FLR,RNF144AA,MARCH5L,NEURL3,ITCHA
    protein-glycine ligase activity RNF144AB,MYLIPB,RNF180,ZNRF2B,SHRPRBCK1R,RC3H2,RAG1,SIAH2L,TTLL3,UBR1

    Interacting Protein

    TRIM50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM50 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM50.

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