TRIM50

  • Official Full Name

    tripartite motif containing 50

  • Synonyms

    TRIM50;tripartite motif containing 50;TRIM50A, tripartite motif containing 50 , tripartite motif containing 50A;E3 ubiquitin-protein ligase TRIM50;FLJ32804;E3 ubiquitin ligase;tripartite motif protein 50;tripartite motif-containing 50;tripartite

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E. coli
  • His
  • DDK
  • Myc
  • Avi
  • Fc
  • GST

    Involved Pathway

    TRIM50 involved in several pathways and played different roles in them. We selected most pathways TRIM50 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    presentation FCGR1B,ASB18,ATG7,ASB11,DTX3L,ARIH2,FBXO27,RNF25,ASB17,TRIM39
    Antigen processing: Ubiquitination &amp GAN,ASB2,DZIP3,SH3RF1,UBE2V1,RNF123,TRIM39,LTN1,SPSB1,UBR1
    Adaptive Immune System KIF18A,CLEC2B,LTN1,WSB1,CREB1,EGFR,FRS2B,CD200R1,EGF,KLRB1B
    Immune System HBL3,LRRFIP1,Mill2,ASB14,CYBA,RNF14,TRIM56,MX2,FCN3,NLRP4B
    Class I MHC mediated antigen processing &amp UFL1,UBE2U,RNF34,ASB10,ASB8,SH3RF1,ASB9,ASB13,RNF25,ERAP1
    Proteasome degradation RNF138,PJA1,UBE2J2,UBR1,RNF34,RNF14,RNF220,CMTM2A,TRIM39,ASB8

    Protein Function

    TRIM50 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity,coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM50 itself. We selected most functions TRIM50 had, and list some proteins which have the same functions with TRIM50. You can find most of the proteins on our site.

    Function Related Protein
    protein-glutamic acid ligase activity SIAH1A,G2E3,MYLIPA,ITCHA,RNF169,RNF144AA,LTN1,RAG1,RFWD2,RNF180
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity NEURL3,ITCHA,RAG1,UBE2IB,G2E3,LTN1,UBR1,SHRPRBCK1R,ZNRF2B,HECW2
    protein binding ORC3L,ZHX1,PPP4R1,ICAM4,FRG1,KLHL3,GPANK1,RAB7A,HAND1,HBA1
    protein-glycine ligase activity, initiating UBR1,RFWD2,UBE2IA,UBE2IB,MARCH11,RNF144AA,TMEM129,HECW2,ITCHA,NEURL1B
    tubulin-glutamic acid ligase activity MUL1A,G2E3,TTLL1,MYLIPB,RAG1,UBE2IA,RNF144AB,HERC2,UBE2IB,DTX1
    tubulin-glycine ligase activity ITCHA,NEURL1B,TMEM129,MARCH11,ZNRF2B,UBE2IA,RNF144AA,TRIM71,RAG1,MUL1A
    coenzyme F420-0 gamma-glutamyl ligase activity NEURL3,ZNRF3,MYLIPB,UBR1,RAG1,MARCH4,SIAH2L,TRIM71,RNF180,UBE2IA
    ribosomal S6-glutamic acid ligase activity NEURL3,MYLIPA,TRIM71,ITCHA,RNF144AA,RNF149,HECW2,ARIH1L,RNF144AB,MARCH6
    zinc ion binding RNF214,TRIM8,CNBP,TRIM56,FHL2B,USP33,RNF212,MMP8,PRKCBA,GTF2B

    Interacting Protein

    TRIM50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM50 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM50.

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