TRIM50

  • Official Full Name

    tripartite motif containing 50

  • Synonyms

    TRIM50;tripartite motif containing 50;TRIM50A, tripartite motif containing 50 , tripartite motif containing 50A;E3 ubiquitin-protein ligase TRIM50;FLJ32804;E3 ubiquitin ligase;tripartite motif protein 50;tripartite motif-containing 50;tripartite

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E. coli
  • His
  • DDK
  • Myc
  • Avi
  • Fc
  • GST

    Involved Pathway

    TRIM50 involved in several pathways and played different roles in them. We selected most pathways TRIM50 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Class I MHC mediated antigen processing &amp KLHL21,RNF182,MKRN1,FBXO44,PJA2,DTX3L,UBA5,TRIM9,UBE2L6,UBE2E3
    Adaptive Immune System UBR1,ASB3,LILRA3,FRS2A,LAIR1,TRIM39,PAG1,BTLA,NRG3,TRIM41
    Antigen processing: Ubiquitination &amp FBXO44,SPSB1,TRIM69,RNF111,RNF182,ASB4,DZIP3,FBXO3,ASB17,RBCK1
    Immune System POLR3G,CASP4,EIF4E3,NOD1,AF251705,CTS7,IFI6,CXADR,TRIM31,GRAP2B
    presentation UBE2F,CTSL2,ERAP2,LRR1,ASB17,SEC23A,WWP1,ARIH2,ASB18,SEC61B
    Proteasome degradation HUWE1,LTN1,SPSB1,ASB2,MKRN1,PJA1,KLHL21,TRAF7,ASB11,LRR1

    Protein Function

    TRIM50 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity,coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM50 itself. We selected most functions TRIM50 had, and list some proteins which have the same functions with TRIM50. You can find most of the proteins on our site.

    Function Related Protein
    protein binding SNRPN,FAM20A,DNM3,IMPA2,ZNF785,ACVR1B,CLEC18A,CRTC1,FRMD8,BBS4
    metal ion binding DBR1,FAM164C,TIPARP,UBA5,ZNF189,TRIM41,PRKRIR,XPNPEP2,ZNF560,ALOX8
    protein-glycine ligase activity, elongating RAG1,TRIM41,ITCHA,RNF144AA,MARCH4,LTN1,MARCH11,RNF169,NEURL1B,RFWD2
    zinc ion binding PIAS1,SQSTM1,ZDHHC23B,CSRP2,CRIP2,MMP3,PGLYRP3,AGBL4,ZNF205,ESR2A
    coenzyme F420-2 alpha-glutamyl ligase activity MGRN1A,ZNRF2B,RNF169,NEURL1B,SIAH2L,TMEM129,SHRPRBCK1R,SIAH1A,ARIH1L,MYLIPA
    tubulin-glutamic acid ligase activity UBE2IB,RNF180,ARIH1L,RNF149,DTX1,ZNRF2B,MGRN1A,HECW2,MARCH4,RAG1
    coenzyme F420-0 gamma-glutamyl ligase activity DTX1,RNF180,ZNRF2B,SIAH2L,RC3H2,NEURL3,RNF144AA,RAG1,MYLIPA,HERC2
    tubulin-glycine ligase activity TRIM71,SIAH2L,RAG1,SIAH1A,RNF180,DTX1,RNF149,MGRN1A,FLR,MARCH9
    protein-glutamic acid ligase activity MARCH9,ITCHA,TRIM71,LTN1,SIAH2L,DTX1,RNF187,UBR1,SHRPRBCK1R,ARIH1L

    Interacting Protein

    TRIM50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM50 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM50.

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