TRIM50

  • Official Full Name

    tripartite motif containing 50

  • Synonyms

    TRIM50;tripartite motif containing 50;TRIM50A, tripartite motif containing 50 , tripartite motif containing 50A;E3 ubiquitin-protein ligase TRIM50;FLJ32804;E3 ubiquitin ligase;tripartite motif protein 50;tripartite motif-containing 50;tripartite

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E. coli
  • His
  • DDK
  • Myc
  • Avi
  • Fc
  • GST

    Involved Pathway

    TRIM50 involved in several pathways and played different roles in them. We selected most pathways TRIM50 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Class I MHC mediated antigen processing &amp ASB10,RBCK1,RNF138,UBR2,SH3RF1,FBXO27,RNF34,STUB1,UBE2J2,RNF4
    Proteasome degradation SPSB2,UBE2V2,ATG7,MKRN1,ASB11,RNF6,RBCK1,ASB8,RNF4,ASB14
    presentation RNF220,DTX3L,HUWE1,TRIM9,UBE2V2,CD207,UBR1,LRR1,SEC24A,SPSB4
    Immune System UBE2E3,SPSB4,RNF216,RAPGEF4,BTLA,KIFAP3,PJA1,CRTAM,CSHL1,DEFB4B
    Adaptive Immune System FBXO17,SIGLEC9,RNF111,LILRB2,LRR1,AKT3,CD300LB,AP1S3A,ARIH2,TRAT1
    Antigen processing: Ubiquitination &amp KLHL21,ASB6,UBE2V2,UFL1,ASB13,PJA2,RNF138,RNF123,TRIM39,TPP2

    Protein Function

    TRIM50 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity,coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM50 itself. We selected most functions TRIM50 had, and list some proteins which have the same functions with TRIM50. You can find most of the proteins on our site.

    Function Related Protein
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity RNF187,DTX1,ZNRF3,MARCH4,MARCH5L,RAG1,RC3H2,TMEM129,HECW2,MYLIPA
    zinc ion binding ZFP346,CNBPA,NSMCE1,KDM7AB,TRAF2,AMFR,SEC24A,BTR09,EHMT2,SPRYD5
    protein-glutamic acid ligase activity NEURL1B,SIAH2L,RFWD2,MARCH11,RNF180,RAG1,MARCH9,RNF169,NEURL3,UBE2IA
    tubulin-glycine ligase activity ARIH1L,MARCH11,UBE2IA,FLR,G2E3,MGRN1A,RAG1,MARCH9,RNF144AB,MYLIPA
    ligase activity LNX1,KCNG4,RNF19B,E4F1,CTPS1A,RNF25,HERC4,HECW1B,PIAS1,RNF217
    protein binding PDIA2,REPS1,ACTB,AXL,ADAM9,LMO2,GPS2,PRKAG1,CDC37L1,MLF1
    coenzyme F420-0 gamma-glutamyl ligase activity TMEM129,RNF149,MUL1A,HERC2,NEURL1B,UBE2IA,UBE2IB,SIAH2L,RNF187,ZNRF3
    tubulin-glutamic acid ligase activity NEURL1B,SIAH2L,G2E3,HERC2,MARCH9,RNF144AA,RNF180,TRIM41,TTLL1,ZNRF2B
    protein-glycine ligase activity, initiating MARCH5L,HECW2,TRIM71,UBE2IA,MARCH9,ITCHA,RNF187,RNF169,NEURL3,RNF144AB

    Interacting Protein

    TRIM50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM50 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM50.

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