TRIM50

  • Official Full Name

    tripartite motif containing 50
  • Synonyms

    TRIM50;tripartite motif containing 50;TRIM50A, tripartite motif containing 50 , tripartite motif containing 50A;E3 ubiquitin-protein ligase TRIM50;FLJ32804;E3 ubiquitin ligase;tripartite motif protein 50;tripartite motif-containing 50;tripartite

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E. coli
  • His
  • DDK
  • Myc
  • Avi
  • Fc
  • GST

    Involved Pathway

    TRIM50 involved in several pathways and played different roles in them. We selected most pathways TRIM50 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Proteasome degradation RNF6,SPSB2,UBE2L6,ARIH2,TRIM69,UBE2V1,PJA1,TRIM11,TRIM9,CMTM2A
    presentation FBXO3,SPSB4,TRIM63,RNF6,STUB1,UBE2U,WWP1,RNF182,SH3RF1,TRIM11
    Adaptive Immune System SIGLEC9,TREML1,CLTA,STUB1,KIF15,KIF2A,Siglece,AP1G1,FRS2A,ASB17
    Class I MHC mediated antigen processing &amp KLHL20,CTSS,RNF144B,RNF123,RNF14,SPSB1,STUB1,ATG7,UFL1,B2ML
    Immune System ASB13,KPNA5,CTLA4,CD300LG,DDOST,DEFB103A,TRIM26,SEC61B,ABI1B,CD300LB
    Antigen processing: Ubiquitination &amp RBCK1,BLMH,UBE2F,LTN1,TPP2,RNF34,UBA5,KLHL21,ASB18,ARIH2

    Protein Function

    TRIM50 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity,coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM50 itself. We selected most functions TRIM50 had, and list some proteins which have the same functions with TRIM50. You can find most of the proteins on our site.

    Function Related Protein
    ligase activity NEDD4L,RNF217,TRIML1,UBR1,RNF13,UBE2F,WWP1,UBE2G1A,NSMCE1,CBX4
    coenzyme F420-0 gamma-glutamyl ligase activity DTX1,RC3H2,MUL1A,MYLIPA,TRIM41,HECW2,ZNRF2B,G2E3,ZNRF3,LTN1
    protein-glycine ligase activity RNF187,UBE2IA,G2E3,DTX1,TRIM71,MARCH6,MYLIPA,MARCH5L,RFWD2,HERC2
    zinc ion binding NR1D4A,CPA2,MYNN,PHC2A,NR2F1,SAMHD1,ZCWPW2,RNF166,ADAM15,ZDHHC21
    ribosomal S6-glutamic acid ligase activity MYLIPA,MARCH11,ZNRF3,UBE2IA,RAG1,UBE2IB,G2E3,LTN1,MARCH4,MARCH5L
    coenzyme F420-2 alpha-glutamyl ligase activity ZNRF2B,ZNRF3,MARCH5L,NEURL1B,TMEM129,HERC2,RAG1,SIAH1A,RNF169,SHRPRBCK1R
    protein binding RABGEF1,ALOX12B,TTC12,GNB2,ATP4B,GTF2B,INSIG1,RTN4RL2B,BEX5,PTPMT1
    protein-glycine ligase activity, initiating MARCH6,RNF144AA,RNF144AB,SIAH1A,RNF169,SIAH2L,NEURL3,MGRN1A,HECW2,UBR1
    protein-glutamic acid ligase activity SIAH2L,ITCHA,RNF187,SIAH1A,MARCH5L,MARCH11,MYLIPB,LTN1,TRIM41,UBE2IA

    Interacting Protein

    TRIM50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM50 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM50.

    Resources

    References

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