TRIM68

  • Official Full Name

    tripartite motif containing 68

  • Overview

    This gene encodes a protein which contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted to prostate. This gene was also found to be differentially expressed in androgen-dependent versus androgen-independent prostate cancer cells.

  • Synonyms

    TRIM68;tripartite motif containing 68;ring finger protein 137 , RNF137, tripartite motif containing 68;E3 ubiquitin-protein ligase TRIM68;FLJ10369;SS 56;MGC126176;RING finger protein 137;RNF 137;RNF137;Ro/SSA1 related protein;SS56;SSA protein SS 56;TRIM 68;Tripartite motif containing protein 68;SSA protein SS-56;OTTHUMP00000230828;OTTHUMP00000230830;tripartite motif-containing 68;tripartite motif-containing protein 68;GC109;SS-56

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • Wheat Germ
  • His
  • Non
  • GST
  • DDK
  • Myc
  • Flag
  • Avi
  • Fc

    Involved Pathway

    TRIM68 involved in several pathways and played different roles in them. We selected most pathways TRIM68 participated on our site, such as Cytokine Signaling in Immune system,Immune System,Interferon Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM68 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Immune System ATP6V1G3,SPSB4,TRAF7,CRP,IFITM3,ASB11,LILRB5,DEFB106A,TNRC5,IRAK3
    Interferon Signaling SAMHD1,IFIT8,EIF4G2A,OASL,IRF9,HLA-DQB2,IFI6,IFI35,XAF1,TRIM14
    Cytokine Signaling in Immune system NUP50,FRS2,SOCS3A,IL17RD,RASGRP4,BST2,TNIP2,PEA15A,FRS2B,OASL
    Interferon gamma signaling TRIM38,TRIM5,IRF6,TRIM3,TRIM2,IRF4,TRIM10,TRIM62,HLA-DQB2,TRIM17

    Protein Function

    TRIM68 has several biochemical functions, for example, androgen receptor binding,histone acetyltransferase binding,ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM68 itself. We selected most functions TRIM68 had, and list some proteins which have the same functions with TRIM68. You can find most of the proteins on our site.

    Function Related Protein
    ligase activity RNF20,PET112L,PRPF19,MEX3C,HERC3,KCMF1,DTX4,RNF19A,TTLL13,GLULA
    ubiquitin-protein transferase activity SMURF2,FBXW2,TRIM37,FLJ11011L,RC3H2,RLIM,CBLB,ANKIB1,ZYG11B,MARCH4
    androgen receptor binding KAT5,CDK7,CALR,TCF21,Ar,WIPI1,PRKCBB,PRMT2,FOXH1,CTNNB1
    histone acetyltransferase binding GLI3,MTF1,EID1,ETS1,ZBTB7A,SP1,EGR1,CITED2,CREB1,SIRT2
    zinc ion binding CA2,MSL2,ZSWIM7,RNF151,UBR7,MLL5,ALKBH8,SEC24C,PDLIM7,RNF135

    Interacting Protein

    TRIM68 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM68 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM68.

    UBE2U

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