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TRIM68

Official Full Name

tripartite motif containing 68
Overview

This gene encodes a protein which contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted to prostate. This gene was also found to be differentially expressed in androgen-dependent versus androgen-independent prostate cancer cells.
Synonyms

TRIM68; tripartite motif containing 68; ring finger protein 137 , RNF137, tripartite motif containing 68; E3 ubiquitin-protein ligase TRIM68; FLJ10369; SS 56; MGC126176; RING finger protein 137; RNF 137; RNF137; Ro/SSA1 related protein; SS56; SSA protein SS 56; TRIM 68; Tripartite motif containing protein 68; SSA protein SS-56; OTTHUMP00000230828; OTTHUMP00000230830; tripartite motif-containing 68; tripartite motif-containing protein 68; GC109; SS-56;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
MYC
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TRIM68-3417H	Recombinant Human TRIM68, His-tagged	E.coli	His	136-485aa	$319 / 25ug
Human	TRIM68-763HCL	Recombinant Human TRIM68 293 Cell Lysate	HEK293	N/A		Inquiry
Human	TRIM68-1812H	Recombinant Human TRIM68 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	Trim68-190M	Recombinant Mouse Trim68 Protein, MYC/DDK-tagged	HEK293T	MYC/DDK		Inquiry
Rhesus Macaque	TRIM68-4974R	Recombinant Rhesus monkey TRIM68 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	TRIM68-4788R	Recombinant Rhesus Macaque TRIM68 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	TRIM68-4788R-B	Recombinant Rhesus Macaque TRIM68 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

TRIM68 involved in several pathways and played different roles in them. We selected most pathways TRIM68 participated on our site, such as Cytokine Signaling in Immune system, Immune System, Interferon Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM68 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cytokine Signaling in Immune system	DUSP7;IFIT14;NEFLB;TRIM6;EGR1;KBTBD7;TRIM45;TRIM5;ISG20
Immune System	RNF41;AP1S3A;KLC3;TRIM46;AGER;KIF18A;CD226;HAVCR2;PELI1
Interferon Signaling	IFIT2;IRF2;XAF1;ADAR;IFI6;TRIM14;ARIH1L;FCGR1B;GBP4
Interferon gamma signaling	TRIM38;GBP2;TRIM45;TRIM26;TRIM14;TRIM5;TRIM29;TRIM22;TRIM8

TRIM68 has several biochemical functions, for example, androgen receptor binding, histone acetyltransferase binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM68 itself. We selected most functions TRIM68 had, and list some proteins which have the same functions with TRIM68. You can find most of the proteins on our site.

Function	Related Protein
androgen receptor binding	FOXP1;PRMT2;KDM4C;DDX5;CTNNB1;EP300;PKN1;NCOA3;RAN
histone acetyltransferase binding	TRIM68;PCNA;EPAS1;TAF7;EGR1;HIF1A;CEBPB;KAT2B;FOXP3
ligase activity	CNOT4;KCMF1;TRAF7;RNF182;PARK2;EGR2;DTX1;TRIM6;RNF40
ubiquitin-protein transferase activity	TSPAN17;FBXO2;AMFR;ZNRF3;UBE2E3;SIAH2L;RNF20;UBE2D4;ITCH
zinc ion binding	FBLIM1;MANEA;MAN2C1;SKI;FBXO40.1;KDM2AA;TRIM35-24;SOD1;ADAM9

TRIM68 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM68 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM68.

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