TRIM8 Protein, tripartite motif containing 8

TRIM8

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TRIM8

Official Full Name tripartite motif containing 8
Background The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to nuclear bodies. Its structure is similar to some tumor suppressor proteins and its gene maps to a locus thought to contain tumor suppressor genes.
Synonyms TRIM8; tripartite motif containing 8; ring finger protein 27 , RNF27, tripartite motif containing 8; probable E3 ubiquitin-protein ligase TRIM8; GERP; glioblastoma expressed ring finger protein; AA408830; BB006755; Lioblastoma expressed ring finger protein; Ring finger protein 27; RNF27; RP11-47A8.4; Tripartite motif protein TRIM8; tripartite motif-containing 8; tripartite motif-containing protein 8; glioblastoma-expressed RING finger protein
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TRIM8-1837HCL Recombinant Human TRIM8 cell lysate N/A
    Human TRIM8-2648H Recombinant Human TRIM8 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse TRIM8-17400M Recombinant Mouse TRIM8 Protein Mammalian Cell His
    Rhesus Macaque TRIM8-4975R Recombinant Rhesus monkey TRIM8 Protein, His-tagged Mammalian Cell His
    Chicken TRIM8-2893C Recombinant Chicken TRIM8 Mammalian Cell His
    Zebrafish TRIM8-4018Z Recombinant Zebrafish TRIM8 Mammalian Cell His

    TRIM8 involved in several pathways and played different roles in them. We selected most pathways TRIM8 participated on our site, such as Cytokine Signaling in Immune system, Immune System, Interferon Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine Signaling in Immune system TRIM22; TRIM2; CNKSR1; MARK3; TRIM14; TRIM46; PRLRB; EIF4A1; RASGRP4; SPTBN1
    Immune System GAN; MGC174155; IRF2; CYLD; CTS7; OASL; UBR1; POLR3H; LAIR2; ACTR1B
    Interferon Signaling IFIT3; GBP4; MX2; IRF9; IFI35; BST2; ADAR; TRIM6; GBP2; HERC5
    Interferon gamma signaling TRIM29; TRIM2; GBP1; IFI30; TRIM8; GBP6; GBP4; TRIM45; TRIM38; TRIM46

    TRIM8 has several biochemical functions, for example, identical protein binding, ligase activity, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM8 itself. We selected most functions TRIM8 had, and list some proteins which have the same functions with TRIM8. You can find most of the proteins on our site.

    Function Related Protein
    identical protein binding SHANK1; GBP1; SP100; AMOTL2; ATXN3; CLDND; TYSND1; ABCD1; SMG9; P2RX2
    ligase activity UBR3; UBE2D1B; TRIM22; HERC3; LTN1; RNF144AB; COP1; UBR5; HERC4; TNFAIP3
    protein homodimerization activity BCL2A1; MAPK4; SDCBP2; BCL2L1; ABCD3; SLC24A6; CARD9; AP1S2; OSTA; NOS2
    zinc ion binding BTR12; HNF4A; ZCCHC8; ZCCHC10; TRIM47; ZRANB3; PTGR1; NHLRC1; QPCTLA; RXRAA

    TRIM8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM8 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM8.

    TRAF5; UBE2L6; TRIM24; RNF113A; TRIM27; TRIM21; CBL; UBE2D1; CCNH; UBE2D3; UBE2D2; XIAP; MKRN3; UBE2V1; TRIM25; recN; RNF111

    Caratozzolo, MF; Valletti, A; et al. TRIM8 anti-proliferative action against chemo-resistant renal cell carcinoma. ONCOTARGET 5:7446-7457(2014).
    Engstrom, KS; Hossain, MB; et al. Efficient Arsenic Metabolism - The AS3MT Haplotype Is Associated with DNA Methylation and Expression of Multiple Genes Around AS3MT. PLOS ONE 8:-(2013).

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