trpv4
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  • Official Full Name
  • transient receptor potential cation channel, subfamily V, member 4
  • Background
  • a cation-selective channel; activated in response to systemic osmotic pressure
  • Synonyms
  • TRPV4; transient receptor potential cation channel, subfamily V, member 4; transient receptor potential cation channel subfamily V member 4; CMT2C; osmosensitive transient receptor potential channel 4; OTRPC4; TRP12; VR OAC; VRL 2; VROAC; osm-9-like TRP c
Cat.#:TRPV4-17463MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TRPV4 Protein
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Cat.#:TRPV4-6305RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TRPV4 Protein
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Cat.#:TRPV4-6258CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TRPV4
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Cat.#:TRPV4-3831ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TRPV4
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Cat.#:TRPV4-730HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TRPV4 293 Cell Lysate
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Cat.#:TRPV4-731HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TRPV4 293 Cell Lysate
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Cat.#:CSC-RI0203Tag:
Source (Host):Species:Human
Product nameHuman TRPV4 Stable Cell Line-CHO
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Involved Pathway

TRPV4 involved in several pathways and played different roles in them. We selected most pathways TRPV4 participated on our site, such as Inflammatory mediator regulation of TRP channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPV4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inflammatory mediator regulation of TRP channels
PLCB1; PLCG1; NTRK1; CALM3; PPP1CC; CALML3; TRPA1; PLA2G4C; PIK3R3; PLA2G4F

Protein Function

TRPV4 has several biochemical functions, for example, ATP binding, SH2 domain binding, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPV4 itself. We selected most functions TRPV4 had, and list some proteins which have the same functions with TRPV4. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein HSP70L; UBE2K; TTF2; STK32C; KIF2B; ABCB3L1; ACSF2; NPR1A; PSTK; CDC42BPG
Function SH2 domain binding
Related Protein CRK; MS4A2; LAX1; NUP62; TRPV4; AFAP1L2; LILRB1; JAK2; KHDRBS2; IRS1
Function actin binding
Related Protein FKBP15; FMN1; MKL1; LSP1; ABLIM1B; MYH1B; VILL; PARVB; PALLD; EZR
Function actin filament binding
Related Protein WIPF1A; SHROOM1; SYNE2; ARPC1A; ABL2; MYH9A; SYNE3; AIF1L; MYO18A; EGFR
Function alpha-tubulin binding
Related Protein HDAC6; WASH; INO80; PROL1; SLC6A2; FNTA; PACRG; ARL8B; DDL-2; PPARGC1A
Function beta-tubulin binding
Related Protein GABARAPL2; VAPB; GABARAP; CASC1; TBCD; ADNP; LRPPRC; AKAP1; ARL8A; SLC6A2
Function calcium channel activity
Related Protein TRPC7A; P2RX1; TRPM8; CACNG8A; ITPR1; TRPM4; GRIN3A; SLC24A4; TRPV2; TRPM6
Function calmodulin binding
Related Protein MYH1B; MYO5A; PCDP1; MYO1D; MYO3A; NOS3; CAMK2D; CALD1; MYO1F; CNGA2
Function cation channel activity
Related Protein TRPV2; TRPM1; FAM26D; ASIC1A; ACCN3; MCOLN1; PKD2L1; CALHM2; FAM38B; TRPV4
Function microtubule binding
Related Protein RPS3; KIF1C; KATNA1; JAKMIP2; MAP205; MAPRE1B; NUMA1; PAFAH1B1B; RACGAP1; KIF23
Function osmosensor activity
Related Protein TRPV4
Function protein binding
Related Protein TUBA3E; FAM114A1; ZFP346; RC3H2; GPSM2; SMAD3; GABARAP; GCHFR; MSI2; LIMS3L
Function protein kinase C binding
Related Protein PARD3; DACT1; FEZ1; SDC4; DACT2; DACT3; MARCKS; TDG; TIRAP; TWF2
Function protein kinase binding
Related Protein PTK2; GDF3; EEF1A1; HIF1A; ARHGEF7; ZFP36; TP53; MSH2; MEF2A; PPP1R15A
Function stretch-activated, cation-selective, calcium channel activity
Related Protein TRPV4

Interacting Protein

TRPV4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPV4 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPV4.
HIF1AN; RAN; ouabain; ARRB2; CANX

TRPV4 Related Articles

Dussor, G; Yan, J; et al. Targeting TRP Channels For Novel Migraine Therapeutics. ACS CHEMICAL NEUROSCIENCE 5:1085-1096(2014).
Lee, JC; Choe, SY; et al. Age-related changes in the distribution of transient receptor potential vanilloid 4 channel (TRPV4) in the central nervous system of rats. JOURNAL OF MOLECULAR HISTOLOGY 45:497-505(2014).