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TRPV4

  • Official Full Name

    transient receptor potential cation channel, subfamily V, member 4

  • Overview

    a cation-selective channel; activated in response to systemic osmotic pressure
  • Synonyms

    TRPV4; transient receptor potential cation channel, subfamily V, member 4; transient receptor potential cation channel subfamily V member 4; CMT2C; osmosensitive transient receptor potential channel 4; OTRPC4; TRP12; VR OAC; VRL 2; VROAC; osm-9-like TRP c;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Flag
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TRPV4-730HCL Recombinant Human TRPV4 293 Cell Lysate HEK293 N/A
Human TRPV4-731HCL Recombinant Human TRPV4 293 Cell Lysate HEK293 N/A
Human TRPV4-1177HFL Recombinant Human TRPV4 protein, His&Flag-tagged HEK293 His&Flag 1-824 aa
Mouse TRPV4-17463M Recombinant Mouse TRPV4 Protein Mammalian Cell His
Mouse TRPV4-9661M Recombinant Mouse TRPV4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TRPV4-9661M-B Recombinant Mouse TRPV4 Protein Pre-coupled Magnetic Beads HEK293
Rat TRPV4-6305R Recombinant Rat TRPV4 Protein Mammalian Cell His
Rat TRPV4-5962R Recombinant Rat TRPV4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TRPV4-5962R-B Recombinant Rat TRPV4 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish TRPV4-3831Z Recombinant Zebrafish TRPV4 Mammalian Cell His
Chicken TRPV4-6258C Recombinant Chicken TRPV4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TRPV4 Related Articles

TRPV4 involved in several pathways and played different roles in them. We selected most pathways TRPV4 participated on our site, such as Inflammatory mediator regulation of TRP channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPV4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Inflammatory mediator regulation of TRP channelsTRPA1;PIK3R3;PTGER4;PRKACB;CALM2;CYP2C70;CYP2J2;PRKACA;PLCG2

TRPV4 has several biochemical functions, for example, ATP binding, SH2 domain binding, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPV4 itself. We selected most functions TRPV4 had, and list some proteins which have the same functions with TRPV4. You can find most of the proteins on our site.

Function Related Protein
ATP bindingKTI12;PRKDC;CSK;ABCG2B;RAD17;KIF19;HSP90AA1.2;ADCK1;CPS1
SH2 domain bindingTRPV4;SIT1;PAG1;SYNGR3;ARHGAP5;CRK;IRS1;PTK2;SQSTM1
actin bindingMACF1;FXYD5;CNN3;PFN3;SHANK3;SCIN;YWHAH;CAPZA2;FSCN1A
actin filament bindingSVIL;ACTN4;ESPN;JUB;WIPF1;VIL1;DBNL;SHROOM2;AASS
alpha-tubulin bindingHDAC6;CAV3;NDEL1;RACGAP1;WASH1;SNCA;SERPINB1A;PACRG;TRPV4
beta-tubulin bindingAKAP1;UXT;HDAC6;ARL8A;PDCD5;IFT74;EMD;CASC1;TRPV4
calcium channel activityCATSPER2;PKD2L2;TRPV5;CHRNA9;SLC24A1;AKR1C1;RYR2;TRPM8;MCU
calmodulin bindingMAPKAPK5;SPA17;MYLK;KCNN1B;CAMKK2;ATP2B1;CAMSAP1;STRN4;MKNK1
cation channel activityPKD2L1;GRIN2A;GRIN3B;GRIN2C;FAM38A;PKD1;ASIC1C;ASIC1A;TRPM1
microtubule bindingTRIM54;FAM83D;CEP57;PEX14;KIF4A;KIF15;KIF17;JAKMIP3;REEP4
osmosensor activity
protein bindingVPS26A;RBM14;PLEKHF1;STAT6;MPHOSPH8;PPP1R16A;TFF3;SPCS1;RARS
protein kinase C bindingTWF2;GNB2L1;SQSTM1;TOP2B;SDPR;MARCKS;TOP2A;TRPV4;PRKCSH
protein kinase bindingCCNE2;SPDYE2;GATA4;SPRY2;DLG1;IBTK;TBC1D14;CCNL1;NEK9
stretch-activated, cation-selective, calcium channel activity

TRPV4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPV4 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPV4.

HIF1AN; RAN; ouabain; ARRB2; CANX

Dussor, G; Yan, J; et al. Targeting TRP Channels For Novel Migraine Therapeutics. ACS CHEMICAL NEUROSCIENCE 5:1085-1096(2014).
Lee, JC; Choe, SY; et al. Age-related changes in the distribution of transient receptor potential vanilloid 4 channel (TRPV4) in the central nervous system of rats. JOURNAL OF MOLECULAR HISTOLOGY 45:497-505(2014).
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