TTC8
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Official Full Name
tetratricopeptide repeat domain 8
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Overview
This gene encodes a protein that has been directly linked to Bardet-Biedl syndrome. The primary features of this syndrome include retinal dystrophy, obesity, polydactyly, renal abnormalities and learning disabilities. Experimentation in non-human eukaryotes suggests that this gene is expressed in ciliated cells and that it is involved in the formation of cilia. Alternate transcriptional splice variants have been characterized. -
Synonyms
TTC8; tetratricopeptide repeat domain 8; tetratricopeptide repeat protein 8; BBS8; Bardet Biedl syndrome 8 protein; Bardet Biedl syndrome type 8; TPR repeat protein 8; TTC 8; OTTHUMP00000244652; OTTHUMP00000244653; OTTHUMP00000244654; OTTHUMP00000244656; OTTHUMP00000244659; Bardet-Biedl syndrome type 8; bardet-Biedl syndrome 8 protein; RP51;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
TTC8 involved in several pathways and played different roles in them. We selected most pathways TTC8 participated on our site, such as Assembly of the primary cilium, BBSome-mediated cargo-targeting to cilium, Cargo trafficking to the periciliary membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with TTC8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Assembly of the primary cilium | TTC30A;CDK5RAP2;ODF2B;CCDC123;CEP70;TSGA14;NPHP1;CEP290;PCM1 |
| BBSome-mediated cargo-targeting to cilium | LZTFL1;SSTR3;CCT8;CCT3;CCT2;BBS2;TTC8;BBS9;MKKS |
| Cargo trafficking to the periciliary membrane | ARL13B;BBS10;ARL3;MKKS;BBS7;TCP1;NPHP3;LZTFL1;CCT5 |
| Organelle biogenesis and maintenance | IFT22;TMEM216;FLR;CEP97;ARL13B;MRPL37;MRPL41;RPGRIP1L;MRPS34 |
TTC8 has several biochemical functions, for example, RNA polymerase II repressing transcription factor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TTC8 itself. We selected most functions TTC8 had, and list some proteins which have the same functions with TTC8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II repressing transcription factor binding | BBS4;TCERG1;BBS2;HDAC2;HDAC1;GSC;BBS10;BBS5;BBS1 |
| protein binding | FRG1;ADRB2;IGSF1;SERPINA3;HADHB;BTG3;TMED1;TDP1;FRAS1 |
TTC8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TTC8 here. Most of them are supplied by our site. Hope this information will be useful for your research of TTC8.
BBS1; BBS7; BBS4; BBS2; Sstr3; BBS9; BBS5; ARL6
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