tuba1b
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  • Official Full Name
  • tubulin, alpha 1b
  • Background
  • Microtubules are required for many well characterized functions in eukaryotic cells, including the movement of chromosomes in mitosis and meiosis, intracellular transport, establishment and maintenance of cellular morphology, cell growth, cell migration and morphogenesis in multicellular organisms. The building block of a microtubule is the tubulin subunit, a heterodimer of alpha and beta-tubulin. Both of these monomers are found in all eukaryotes, and their sequences are highly conserved. Acetylated alpha tubulin is present in various microtubule structures and plays a role in stabilizing the structures of all microtubules.
  • Synonyms
  • TUBA1B; tubulin, alpha 1b; K-ALPHA-1; tubulin alpha-1B chain; alpha tubulin; tubulin K-alpha-1; alpha-tubulin ubiquitous; tubulin, alpha, ubiquitous; tubulin alpha-ubiquitous chain; Acetylated alpha tubulin
Cat.#:TUBA1B-26HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TUBA1B protein, MYC/DDK-tagged
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Cat.#:TUBA1B-31629THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TUBA1B
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Cat.#:TUBA1B-3486HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TUBA1B, GST-tagged
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Cat.#:TUBA1B-38HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TUBA1B, His-tagged
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Cat.#:TUBA1B-17609MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TUBA1B Protein
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Cat.#:TUBA1B-6355RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TUBA1B Protein
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Cat.#:TUBA1B-1061CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TUBA1B Protein, His-tagged
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Cat.#:TUBA1B-5024RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TUBA1B Protein, His-tagged
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Cat.#:TUBA1B-9738ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TUBA1B
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Cat.#:TUBA1B-661HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TUBA1B 293 Cell Lysate
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Involved Pathway

TUBA1B involved in several pathways and played different roles in them. We selected most pathways TUBA1B participated on our site, such as Chaperonin-mediated protein folding, Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, Formation of tubulin folding intermediates by CCT/TriC, which may be useful for your reference. Also, other proteins which involved in the same pathway with TUBA1B were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chaperonin-mediated protein folding
CCT5; PFDN5; NOP56; PFDN6; TUBA3D; PFDN2; TUBB4A; CCT4; CCT8; CCT3
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
TUBB4A; PFDN4; CCT6A; CCT7; PFDN2; TUBB4B; CCT2; CCT5; PFDN6; CCT3
Formation of tubulin folding intermediates by CCT/TriC
CCT4; CCT2; CCT7; TCP1; TUBB4A; CCT5; CCT8; TUBA3D; TUBB4B; CCT3
Gap junction
ITPR1; PRKCBA; PDGFRA; GNA11B; MAP2K1; NRAS; PLCB3; TUBA3A; TUBB5; PRKG2
Metabolism of proteins
WDR85; B3GALTL; ALG14; F9A; GPR116; ADAMTS3; TMED2; IGFALS; HSCB; MIA3
Parkin-Ubiquitin Proteasomal System pathway
STUB1; UBE2J2; TUBA1B; SIAH2; RNF19A; HSPA14; TUBA3E; TUBB7P; HSPA7; TUBA3D
Pathogenic Escherichia coli infection
RHOA; ARPC5L; ARHGEF2; NCK2; TUBB6; TUBA8; TUBB2B; TLR4; WAS; CDH1
Phagosome
HLA-DRA; MBL2; ATP6V1BA; HLA-DPB1; FCGR2B; C3; ITGAV; STX7; CORO1A; ATP6V1D

Protein Function

TUBA1B has several biochemical functions, for example, GTP binding, GTPase activity, double-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TUBA1B itself. We selected most functions TUBA1B had, and list some proteins which have the same functions with TUBA1B. You can find most of the proteins on our site.
Function
Related Protein
Function GTP binding
Related Protein RAB40AL; MFN1B; RHOD; RIT2; RAB14; IFT27; GBP5; RAB2A; EFTUD1; GFM2
Function GTPase activity
Related Protein RAB12; DNM1A; RAB8A; RAB34; EEF1A1; RAB11B; NUDT1; RAB39A; ARHGAP5; GNAS
Function double-stranded RNA binding
Related Protein EIF4A1; ELAVL1; BARHL1; MTDH; ADARB1; OAS1; APTX; CLTC; IFIH1; MYH4
Function protein binding
Related Protein STX6; FGF12; PPIL1; SNAP23; NOTCH2; DNALI1; ZNF346; TESK1; C9orf86; RGS20
Function structural constituent of cytoskeleton
Related Protein TUBG1; TUBE1; TUBA1L2; KRT15; NDC80; TUBA8L3; TUBB5; EPB41L3; TUBA1B; ACTL7A
Function structural molecule activity
Related Protein CDC42SE1; CLDN23; EVPL; MTAP7D3; SPRR2G; KRT39; KRT82; MAP4; PSMD13; CYT1L
Function ubiquitin protein ligase binding
Related Protein SKI; CDC34B; CCT2; PRKAR2A; TRAF6; JAK1; PER3; CUL1; TRIB2; CUL3

Interacting Protein

TUBA1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TUBA1B here. Most of them are supplied by our site. Hope this information will be useful for your research of TUBA1B.
TUBB3; AGTRAP; EBNA-LP; YWHAZ; SMAD2; TOM1L1; TMEM253; SLX1A; STARD13; bosutinib; imatinib; dasatinib; midostaurin

TUBA1B Related Articles

Groh, KJ; Schonenberger, R; et al. Analysis of protein expression in zebrafish during gonad differentiation by targeted proteomics. GENERAL AND COMPARATIVE ENDOCRINOLOGY 193:210-220(2013).
Lu, CH; Zhang, J; et al. Increased alpha-Tubulin1b Expression Indicates Poor Prognosis and Resistance to Chemotherapy in Hepatocellular Carcinoma. DIGESTIVE DISEASES AND SCIENCES 58:2713-2720(2013).