Tle4

  • Official Full Name

    transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)

  • Overview

    TLE4 (transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)) is a protein-coding gene. Diseases associated with TLE4 include rabies, and bipolar disorder, and among its related super-pathways are Constitutive Signaling by NOTCH1 PEST Domain Mutants and Signaling by GPCR. GO annotations related to this gene include transcription corepressor activity and molecular_function. An important paralog of this gene is AES.

  • Synonyms

    TLE4;transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila);ESG;BCE1;ESG4;GRG4;BCE-1;E(spI)

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
TLE4-3251H Recombinant Human TLE4, GST-tagged E.coli Human GST 173-243aa
TLE4-938H Recombinant Human TLE4 protein, His-tagged E.coli Human His 173-243 aa
TLE4-16815M Recombinant Mouse TLE4 Protein Mammalian Cells Mouse His
TLE4-5810C Recombinant Chicken TLE4 Mammalian Cells Chicken His
TLE4-1785HCL Recombinant Human TLE4 cell lysate Human Non
TLE4-9233M Recombinant Mouse TLE4 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
TLE4-9233M-B Recombinant Mouse TLE4 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    Tle4 involved in several pathways and played different roles in them. We selected most pathways Tle4 participated on our site, such as Deactivation of the beta-catenin transactivating complex,Degradation of beta-catenin by the destruction complex,Formation of the beta-catenin:TCF transactivating complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tle4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NOTCH1 Intracellular Domain Regulates Transcription TLE3,TUBB3,HEY2,HEY1,TLE2,TLE1,HEYL
    Formation of the beta-catenin:TCF transactivating complex PYGO2,TLE3B,BCL9,PYGO1,H3F3B.1,SMARCA4,LEO1,BCL9L,TLE2,TLE3
    Signal Transduction ARHGEF3,OPHN1,AKAP13,KTN1,METAP1,NTS,PPEF1,OPN4B,NEDD8L,FABP11A
    Signaling by NOTCH HEYL,TLE2,MDKB,TLE3,DNER,RAB6A,DTX2,MDKA,MDK,DLK1
    Degradation of beta-catenin by the destruction complex FAM123B,CTBP1,TLE2,TLE3B,TLE1,CTBP2,AES,TLE3
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription KRT1,TCF4,TLE2,TNIK,BCL9,CBY1,ZCCHC12,SALL4,TLE1,AES
    Deactivation of the beta-catenin transactivating complex SOX4A,SOX7,PYGO2,BCL9L,ASH2L,CBY1,C,RBBP5,SRY,PYGO1
    Repression of WNT target genes AES,TLE2,TLE3B,TLE3

    Protein Function

    Tle4 has several biochemical functions, for example, chromatin binding,molecular_function,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tle4 itself. We selected most functions Tle4 had, and list some proteins which have the same functions with Tle4. You can find most of the proteins on our site.

    Function Related Protein
    molecular_function SERF2,LMF2B,TMEM8,TMEFF2,TMEM88A,GM15308,REP15,ZNF777,DOCK10,KRT24
    chromatin binding CHD8,LEF1,NSD1,CHD7,C10orf119,MSL1A,TDRD3,LMO2,CHAF1B,ZFP354B
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding TFAP4,RELA,MYOD1,CREB1,MYF6,LEF1,HIF1A,USF1,IRF8,NFATC1
    transcription corepressor activity SIRT6,DRAP1,HDAC9,TBL1XR1A,MXD1,TFCP2L1,LHX1,TDP2,JUNB,YAP1
    repressing transcription factor binding NFYB,HDAC7A,CTNNB1,TCF3,PRDM5,MYC,SRI,HDAC5,CBX5,MAGEA2B
    protein binding ADORA2A,CAMSAP1L1,DDRGK1,FRMD5,SPRR1A,C12orf68,STX3,IL1RN,RCN3,NAPA

    Interacting Protein

    Tle4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tle4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Tle4.

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