| Official Full Name | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) |
| Background | TLE4 (transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)) is a protein-coding gene. Diseases associated with TLE4 include rabies, and bipolar disorder, and among its related super-pathways are Constitutive Signaling by NOTCH1 PEST Domain Mutants and Signaling by GPCR. GO annotations related to this gene include transcription corepressor activity and molecular_function. An important paralog of this gene is AES. |
| Synonyms | TLE4; transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila); ESG; BCE1; ESG4; GRG4; BCE-1; E(spI) |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Tle4 involved in several pathways and played different roles in them. We selected most pathways Tle4 participated on our site, such as Deactivation of the beta-catenin transactivating complex, Degradation of beta-catenin by the destruction complex, Formation of the beta-catenin:TCF transactivating complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tle4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Deactivation of the beta-catenin transactivating complex | TLE3; TLE1; SOX4A; PYGO1; TLE4; SOX13; C; RBBP5; SRY; SOX9A |
| Degradation of beta-catenin by the destruction complex | TLE1; TLE3; AES; CTBP2; TLE2; CTBP1; FAM123B; TLE4; TLE3B |
| Formation of the beta-catenin:TCF transactivating complex | SMARCA4; LEO1; CDC73; H3F3D; TLE4; H3F3B.1; PYGO1; TLE3B; TLE1; TLE3 |
| NOTCH1 Intracellular Domain Regulates Transcription | TLE3; HEYL; HEY2; HEY1; TLE4; TLE2; TLE1; TUBB3 |
| Regulation of Wnt-mediated beta catenin signaling and target gene transcription | HBP1; AES; SALL4; CYR61; TLE1; TNIK; TLE2; BCL9; T; TLE4 |
| Repression of WNT target genes | TLE2; AES; TLE3B; TLE4; TLE3 |
| Signal Transduction | GPR55; THBS3B; USP15; ARHGAP1; RGS10; CCL35.1; LPAR2A; PTHLHA; MKL1; TAS2R3 |
| Signaling by NOTCH | MDKA; DNER; MDKB; RAB6A; MDK; DLK1; HEYL; TLE2; TLE4; DTX2 |
Tle4 has several biochemical functions, for example, chromatin binding, molecular_function, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tle4 itself. We selected most functions Tle4 had, and list some proteins which have the same functions with Tle4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | ESR1; SVEP1; PPARGC1A; GATA2B; CIC; SIN3A; SMC1AL; ARNTL1B; EP300; SMC1A |
| molecular_function | FAM26E.1; IGFN1.1; PTCHD3; INO80C; TMEM251; CAGE1; FAM53B; CRYGM2D11; PHYHIPLA; SPINK13 |
| protein binding | MGST3; USP20; TXNL4B; ATF4; C1orf187; OIT3; MRPS23; DDX55; AIMP1; CORO6 |
| repressing transcription factor binding | CTBP1; MAGEA2B; HDAC5; PRDM5; TCF3; GMNN; RUNX2; CTNNB1; NFYB; TBP |
| transcription corepressor activity | ATF5; ZHX3; POU1F1; TFAP2B; LHX1; HDAC7A; KCNIP3; KCNA3; WTIP; FEV |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | MEF2C; TFAP4; SPI1; IRF8; GATA5; OLIG2; NR5A1; MYOG; HNF1B; SRF |
Tle4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tle4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Tle4.
brnQ3; mfd; tcaC1
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