tle4
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  • Official Full Name
  • transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
  • Background
  • TLE4 (transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)) is a protein-coding gene. Diseases associated with TLE4 include rabies, and bipolar disorder, and among its related super-pathways are Constitutive Signaling by NOTCH1 PEST Domain Mutants and Signaling by GPCR. GO annotations related to this gene include transcription corepressor activity and molecular_function. An important paralog of this gene is AES.
  • Synonyms
  • TLE4; transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila); ESG; BCE1; ESG4; GRG4; BCE-1; E(spI)
Cat.#:TLE4-3251HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TLE4, GST-tagged
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Cat.#:TLE4-16815MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TLE4 Protein
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Cat.#:TLE4-5810CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TLE4
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Cat.#:TLE4-1785HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TLE4 cell lysate
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Involved Pathway

Tle4 involved in several pathways and played different roles in them. We selected most pathways Tle4 participated on our site, such as Deactivation of the beta-catenin transactivating complex, Degradation of beta-catenin by the destruction complex, Formation of the beta-catenin:TCF transactivating complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tle4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Deactivation of the beta-catenin transactivating complex
SOX13; TLE1; SOX6; TLE3; C; SOX32; ASH2L; TLE2; SOX9B; SOX9A
Degradation of beta-catenin by the destruction complex
TLE3; TLE1; FAM123B; AES; TLE2; CTBP1; CTBP2; TLE4; TLE3B
Formation of the beta-catenin:TCF transactivating complex
LEO1; TLE3; TLE1; TLE2; TLE3B; ASH2L; CDC73; BCL9; PYGO1; PYGO2
NOTCH1 Intracellular Domain Regulates Transcription
HEYL; TLE2; TLE1; TLE3; TLE4; TUBB3; HEY2; HEY1
Regulation of Wnt-mediated beta catenin signaling and target gene transcription
AES; CBY1; BCL9; TNIK; ZCCHC12; TCF4; SALL4; CYR61; HBP1; TLE4
Repression of WNT target genes
AES; TLE3B; TLE4; TLE3; TLE2
Signal Transduction
RGS9BP; ABI1B; ARHGAP11A; PRC1B; PPEF1; OXTRL; SST1.1; LRP12; RYK; ARHGEF16
Signaling by NOTCH
TLE3; TLE4; HEYL; DTX2; DLK1; DNER; MDK; MDKA; RAB6A; TLE2

Protein Function

Tle4 has several biochemical functions, for example, chromatin binding, molecular_function, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tle4 itself. We selected most functions Tle4 had, and list some proteins which have the same functions with Tle4. You can find most of the proteins on our site.
Function
Related Protein
Function chromatin binding
Related Protein SOX10; BRD3; SOX9; APBB1; SOX14; PBRM1L; ATAD2; POLR3D; FLI1; MEOX1
Function molecular_function
Related Protein MORC2B; EFCAB10; HYI; DCAF12; UCMAA; GM614; KBTBD7; C14orf2; KRTAP26-1; MIS18A
Function protein binding
Related Protein TRPM6; SYNDIG1; CSDC2; GRID2IP; UNC45A; SMAD9; FAM156A; FAM9C; GLUD1; ALOX5AP
Function repressing transcription factor binding
Related Protein MYC; HDAC7A; PRDM5; HDAC5; DDX20; RELA; HDAC4; MAGEA2; HMGB1; TCF3
Function transcription corepressor activity
Related Protein JUB; HDAC7A; LHX9; AEBP2; SMARCA4; SIRT6; ZMYND11; PBXIP1; DDIT3; HIF3A
Function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein HIF1A; FOXF1; SNAI2; SFPI1; TLE4; POU3F1; MITF; PDX1; NKX2-1; MYF6

Interacting Protein

Tle4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tle4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Tle4.
brnQ3; mfd; tcaC1