ube2e3
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  • Official Full Name
  • ubiquitin-conjugating enzyme E2E 3
  • Background
  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
  • Synonyms
  • UBE2E3; ubiquitin-conjugating enzyme E2E 3; ubiquitin conjugating enzyme E2E 3 (homologous to yeast UBC4/5) , ubiquitin conjugating enzyme E2E 3 (UBC4/5 homolog, yeast); ubiquitin-conjugating enzyme E2 E3; UbcH9; ubiquitin-protein ligase E3; ubiquitin ca
Cat.#:UBE2E3-112HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2E3, His-tagged
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Cat.#:UBE2E3-31658THTag:
Source (Host):Species:Human
Product nameRecombinant Human UBE2E3
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Cat.#:UBE2E3-3532HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2E3, GST-tagged
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Cat.#:UBE2E3-647HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2E3 Protein, His-tagged, Active
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Cat.#:UBE2E3-5058RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey UBE2E3 Protein, His-tagged
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Cat.#:UBE2E3-4135CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken UBE2E3
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Cat.#:UBE2E3-11162ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish UBE2E3
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Cat.#:UBE2E3-580HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UBE2E3 293 Cell Lysate
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Cat.#:UBE2E3-581HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UBE2E3 293 Cell Lysate
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Involved Pathway

UBE2E3 involved in several pathways and played different roles in them. We selected most pathways UBE2E3 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2E3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
ASB6; STUB1; CD300LB; KIF2B; ARIH2; CTSK; MOV10; CD226; CDKN1A; PDPK1A
Antigen processing: Ubiquitination &
WSB1; UBE2U; PJA2; ASB17; ASB9; UBA5; LRRC41; ASB6; UBE2V1; UBE2V2
Proteasome degradation
RNF220; KLHL21; STUB1; RBCK1; MKRN1; ARIH2; ASB13; ASB18; RNF14; RNF25
Class I MHC mediated antigen processing &
VPRBP; UBA5; ASB7; ASB6; WWP1; CD207; RNF25; NPEPPS; TRIM69; RNF144B
presentation
ASB7; RNF19B; RNF34; RNF41; UFL1; TRIM63; ARIH2; RNF138; ERAP1; RNF182
Immune System
RNF41; TRIM11; KIF22; CTSO; TRIM5; ASB11; PJA2; IFIT12; SIGIRR; RNF25
Protein processing in endoplasmic reticulum
EIF2AK2; ERN1; GSBP9; MAP2K7; HSPA6; SEC31A; BAXA; SEC24C; DERL1; SEC31B
Ubiquitin mediated proteolysis
TRIP12; PIAS4B; MDM2; UBE2I; BIRC3; UBE2D2L; CUL4A; UBA7; FZR1A; KEAP1
protein ubiquitylation
UBE2U; RNF216; UEVLD; UBE2E3; UBA5

Protein Function

UBE2E3 has several biochemical functions, for example, ATP binding, protein binding, ubiquitin conjugating enzyme activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2E3 itself. We selected most functions UBE2E3 had, and list some proteins which have the same functions with UBE2E3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ALK; CASKA; HSPH1; PRKX; PGK2; PAK7; AKT3A; PIK3CD; PIM1; CPS1
Function protein binding
Related Protein TTC35; ETV4; RBM6; PLXNC1; RGS8; UGGT1; KIAA1191; APOBEC2A; TPT1; XPA
Function ubiquitin conjugating enzyme activity
Related Protein CDC34; UBE2N; UBE2QL1; UBE2B; UBE2H; UBE2V1; UBE2J1; UBE2G1; UBE2O; UBE2D4
Function ubiquitin-protein transferase activity
Related Protein TRAF3; WWP1; ARIH2; UBE2R2; NEDD4L; PEX12; SIAH1A; ZNRF1; RBBP6; SKP1

Interacting Protein

UBE2E3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2E3 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2E3.
RNF5; MID1; RNF185; TRIM39; RNF111; RNF25