UBE2E3

  • Official Full Name

    ubiquitin-conjugating enzyme E2E 3

  • Overview

    The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

  • Synonyms

    UBE2E3;ubiquitin-conjugating enzyme E2E 3;ubiquitin conjugating enzyme E2E 3 (homologous to yeast UBC4/5) , ubiquitin conjugating enzyme E2E 3 (UBC4/5 homolog, yeast);ubiquitin-conjugating enzyme E2 E3;UbcH9;ubiquitin-protein ligase E3;ubiquitin ca

Recombinant Proteins

  • Human
  • Zebrafish
  • Chicken
  • Rhesus macaque
  • E.coli
  • Mammalian Cells
  • HEK293
  • Insect Cells
  • GST
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
UBE2E3-3532H Recombinant Human UBE2E3, GST-tagged E.coli Human GST 1-207aa
UBE2E3-647H Active Recombinant Human UBE2E3 Protein, His-tagged E.coli Human His
UBE2E3-11162Z Recombinant Zebrafish UBE2E3 Mammalian Cells Zebrafish His
UBE2E3-112H Recombinant Human UBE2E3, His-tagged E.coli Human His
UBE2E3-31658TH Recombinant Human UBE2E3 Human Non Full L.
UBE2E3-4135C Recombinant Chicken UBE2E3 Mammalian Cells Chicken His
UBE2E3-5058R Recombinant Rhesus monkey UBE2E3 Protein, His-tagged Mammalian Cells Rhesus macaque His
UBE2E3-580HCL Recombinant Human UBE2E3 293 Cell Lysate HEK293 Human Non
UBE2E3-581HCL Recombinant Human UBE2E3 293 Cell Lysate HEK293 Human Non
UBE2E3-0027H Recombinant Human UBE2E3 Protein (S2-T207), Tag Free Insect Cells Human Non S2-T207
UBE2E3-4871R Recombinant Rhesus Macaque UBE2E3 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
UBE2E3-4871R-B Recombinant Rhesus Macaque UBE2E3 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    UBE2E3 involved in several pathways and played different roles in them. We selected most pathways UBE2E3 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2E3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Protein processing in endoplasmic reticulum DNAJB12A,CKAP4,SSR4,NFE2L2,SEC61AL2,DNAJC5,CALR3B,SIL1,HSPH1,YOD1
    protein ubiquitylation UBE2U,RNF216,UEVLD,UBA5
    Class I MHC mediated antigen processing &amp ASB8,UBA5,LRRC41,UBR2,ASB9,ASB13,CYBA,FBXO44,UBE2L6,ERAP1
    Ubiquitin mediated proteolysis FBXO4,RNF7,TRAF6,PARK2,ANAPC7,ANAPC5,UBE2H,TCEB1B,CBL,TRIM32
    Adaptive Immune System LILRA2,SH3RF1,EGF,AP1S1,EVL,CD226,UBE2L6,WWP1,CD207,RNF220
    Immune System CYLD,IFIT10,EDARADD,CD300LD,MGC174152,WASF2,KIF26A,TXNIPB,CSHL1,CTSO
    Antigen processing: Ubiquitination &amp LRR1,ASB8,HUWE1,UBR2,ASB11,TRIM63,ASB2,TRIM41,ASB9,TRIM39
    Proteasome degradation RNF111,UBE2V1,ASB14,IWS1,ASB7,RNF138,ASB3,UBE2L6,SH3RF1,ASB18
    presentation UBE2L6,TRIM41,SPSB2,ASB11,CYBA,B2ML,RNF6,PJA2,UBE2F,RNF14

    Protein Function

    UBE2E3 has several biochemical functions, for example, ATP binding,protein binding,ubiquitin conjugating enzyme activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2E3 itself. We selected most functions UBE2E3 had, and list some proteins which have the same functions with UBE2E3. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding CHEK1,ABCA7,ATP2B3A,VPS4A,DYRK4,ITM2C,UHMK1,SYN2B,PSMC2,TLK1B
    ubiquitin conjugating enzyme activity UBE2D3,UBE2D2,UBE2Z,UBE2C,UBE2E2,UBE2D4,UBE2D1,UBE2G2,UBE2N,UBE2Q1
    ubiquitin-protein transferase activity RNF182,SKP1,MKRN1,UBE2T,RNF5,TRAF4B,TRIM32,MUL1A,RNF144AA,RC3H2
    protein binding FGF21,VIP,TRIP12,UNG,POLG,EIF1AD,HBP1,TPD52,SYNE3,TAF1D

    Interacting Protein

    UBE2E3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2E3 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2E3.

    RNF5;MID1;RNF185;TRIM39;RNF111;RNF25

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