ube2l6
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  • Official Full Name
  • ubiquitin-conjugating enzyme E2L 6
  • Background
  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
  • Synonyms
  • UBE2L6; ubiquitin-conjugating enzyme E2L 6; ubiquitin/ISG15-conjugating enzyme E2 L6; UBCH8; ubiquitin-protein ligase L6; ubiquitin carrier protein L6; retinoic acid induced gene B protein; retinoic acid-induced gene B protein; RIG-B; MGC40331
Cat.#:UBE2L6-134HTag:
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human UBE2L6
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Cat.#:UBE2L6-30HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ubiquitin-Conjugating Enzyme E2L6, His-tagged
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Cat.#:UBE2L6-31251THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2L6, His-tagged
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Cat.#:UBE2L6-3539HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2L6, GST-tagged
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Cat.#:UBE2L6-7340HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2L6, His tagged
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Cat.#:UBE2L6-928HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2L6 Protein, GST-tagged
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Cat.#:UBE2L6-929HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2L6
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Cat.#:UBE2L6-17724MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse UBE2L6 Protein
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Cat.#:UBE2L6-6402RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat UBE2L6 Protein
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Cat.#:UBE2L6-568HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UBE2L6 293 Cell Lysate
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Cat.#:UBE2L6-569HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UBE2L6 293 Cell Lysate
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Involved Pathway

UBE2L6 involved in several pathways and played different roles in them. We selected most pathways UBE2L6 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2L6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
UBR2; CD300LG; SEC23A; KLHL21; NRG3; EGF; TREML2; NRG4; CD160; TRIM39
Antigen processing: Ubiquitination &
FBXO44; SPSB2; LTN1; ASB4; UFL1; UBE2E3; ASB17; RNF19B; ASB7; TPP2
Proteasome degradation
ARIH2; WSB1; HECTD3; UBE2U; PJA1; RNF111; TRIM41; RNF34; ASB7; TRIM63
Antiviral mechanism by IFN-stimulated genes
JAK1; KPNA3; EIF4G2; KPNA5; EIF4A2; KPNA4; IFIT11; IFIT14; ARIH1; NUP35
Class I MHC mediated antigen processing &
DTX3L; UBE2E3; FBXO27; LRSAM1; RNF138; RNF41; RNF220; HUWE1; BLMH; ASB3
presentation
UBE2V2; ERAP1; SH3RF1; UBR2; UBR1; ASB10; VPRBP; ASB17; ASB13; TRIM11
Cytokine Signaling in Immune system
PEA15; UBE2L6; NEFLB; DPF1; UBE2V1; KPNA5; HAVCR2; PELI3; KPNA3; FRS2A
DNA Damage Bypass
USP43; USP10; POLD3; ZBTB32; MAD2L2; POLI; KIAA0101; USP43A; SPRTN; DDB1
DNA Repair
MAD2L2; RAD17; FAM175A; KIAA0146; ALKBH3; TDP1; PPP4R2A; ASCC1; WRN; MGMT
ISG15 antiviral mechanism
ARIH1; IFIT11; IFIT14; ARIH1L; IFIT12; HERC5; UBE2L6; EIF4G2; USP18; MX2

Protein Function

UBE2L6 has several biochemical functions, for example, ISG15 transferase activity, protein binding, ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2L6 itself. We selected most functions UBE2L6 had, and list some proteins which have the same functions with UBE2L6. You can find most of the proteins on our site.
Function
Related Protein
Function ISG15 transferase activity
Related Protein HERC5; UBE2L6; UBE2E1; UBE2E2
Function protein binding
Related Protein PIGK; HSPD1; KIR2DL1; SNTB2; SLBP; GAN; PACSIN2; CD2BP2; BMPR2; MYRIP
Function ubiquitin-protein transferase activity
Related Protein HERC2; TRIM37; RNF144AA; TRIM27; FBXO7; ITCHA; RCHY1; G2E3; RBBP6; CNOT4

Interacting Protein

UBE2L6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2L6 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2L6.
ARIH2; RNF144B; LONRF1; RBCK1; RNF19B