ube2o
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  • Official Full Name
  • ubiquitin-conjugating enzyme E2O
  • Background
  • Ubiquitin-conjugating enzyme E2 O is a protein that in humans is encoded by the UBE2O gene.
  • Synonyms
  • UBE2O; ubiquitin-conjugating enzyme E2O; ubiquitin-conjugating enzyme E2 O; E2 230K; EC=6.3.2.19; FLJ12878; KIAA1734; Likely Ortholog of Mouse Ubiquitin Conjugating Enzyme; RP23 193A16.5; UBE2O_HUMAN; Ubiquitin carrier protein O; Ubiquitin conjugating enzyme E2 O; Ubiquitin conjugating enzyme E2 of 230 kDa; ubiquitin conjugating enzyme E2O; Ubiquitin protein ligase O; Ubiquitin-conjugating enzyme E2 of 230 kDa; Ubiquitin-conjugating enzyme E2-230K; Ubiquitin-protein ligase O; E2-230K
Cat.#:UBE2O-162HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human UBE2O, GST-tagged
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Cat.#:UBE2O-3541HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2O, His-tagged
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Cat.#:UBE2O-651HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human UBE2O Protein, GST-tagged, Active
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Cat.#:UBE2O-17727MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse UBE2O Protein
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Cat.#:UBE2O-1871HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UBE2O cell lysate
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Involved Pathway

UBE2O involved in several pathways and played different roles in them. We selected most pathways UBE2O participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2O were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ubiquitin mediated proteolysis
SMURF1; CDC34; PIAS1; BIRC3; SKP2; UBE2IB; FLJ11011L; UBE2NA; UBE2M; MID1

Protein Function

UBE2O has several biochemical functions, for example, ATP binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2O itself. We selected most functions UBE2O had, and list some proteins which have the same functions with UBE2O. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PDPK1B; MOCS3; ITPKC; CAMK2A; LIG1; UBE2F; PANK4; UBE2E1; SPG7; MYH13
Function poly(A) RNA binding
Related Protein ZFP36L1; YTHDC1; MTERF; RPS2; GANAB; CPSF7; MYEF2; PUS7; SNW1; PA2G4
Function protein binding
Related Protein GPR177; RAD52; IRF1; ITGA2B; IL32; FOXK2; SND1; NACC2; SLC16A3; TUB
Function ubiquitin conjugating enzyme activity
Related Protein CDC34; UBE2QL1; UBE2D1; UBE2Q1; UBE2J2; UBE2R2; UBE2G2; UBE2O; UBE2D2A; UBE2V2
Function ubiquitin protein ligase activity
Related Protein RNF152; RNF2; LTN1; PDZRN3B; UBE2A; NEDD4; UBR1; ASB4; MED17; PJA1
Function ubiquitin protein ligase binding
Related Protein USP2; HSPA1B; DIO2; BAG6; TRIM28; TNFRSF1B; RRAGA; DBT; PTPN22; TRAF3
Function ubiquitin-protein transferase activity
Related Protein RNF38; TRIM69; LNX1; ANKIB1A; UBE2D1; TRAF4; MARCH4; PARK2; RFWD3; TRIM32

Interacting Protein

UBE2O has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2O here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2O.
APPL1; Smad6; tat; UBE2V1; Smad7; SMAD6; BAP1; Rnf111; RLIM; al554633_hum_protein; TRIM27; RPL12

UBE2O Related Articles

Mashtalir, N; Daou, S; et al. Autodeubiquitination Protects the Tumor Suppressor BAP1 from Cytoplasmic Sequestration Mediated by the Atypical Ubiquitin Ligase UBE2O. MOLECULAR CELL 54:392-406(2014).
Yu, J; Feng, L; et al. Vitreous proteomic analysis of idiopathic epiretinal membranes. MOLECULAR BIOSYSTEMS 10:2558-2566(2014).