UBE4A Protein, ubiquitination factor E4A

UBE4A

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UBE4A

Official Full Name ubiquitination factor E4A
Background This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohns disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms UBE4A; ubiquitination factor E4A; ubiquitination factor E4A (homologous to yeast UFD2) , ubiquitination factor E4A (UFD2 homolog, yeast); ubiquitin conjugation factor E4 A; E4; KIAA0126; UBOX2; UFD2; ubiquitination factor E4A (UFD2 homolog, yeast); MGC13
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • His
    • MYC/DDK
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Ube4a-997M Recombinant Mouse Ube4a Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human UBE4A-3551H Recombinant Human UBE4A, His-tagged E.coli His
    Human UBE4A-480H Recombinant Human UBE4A Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse UBE4A-17741M Recombinant Mouse UBE4A Protein Mammalian Cell His
    Rat UBE4A-6406R Recombinant Rat UBE4A Protein Mammalian Cell His
    Chicken UBE4A-2599C Recombinant Chicken UBE4A Mammalian Cell His

    UBE4A involved in several pathways and played different roles in them. We selected most pathways UBE4A participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ubiquitin mediated proteolysis UBE2G1A; SIAH2L; TRIM32; MGRN1A; UBE2D1A; UBE2B; CUL3B; NEDD4L; NEDD4; BRCA1

    UBE4A has several biochemical functions, for example, GTPase inhibitor activity, Roundabout binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE4A itself. We selected most functions UBE4A had, and list some proteins which have the same functions with UBE4A. You can find most of the proteins on our site.

    Function Related Protein
    GTPase inhibitor activity SLIT2; ARL2; CPEB2; IPO5; PDE6D; UBE4A; TNK2; GPS2; GPS1; RHOH
    Roundabout binding SLIT1A; UBE4A; GM4980; SLIT2; SLIT1B; SLIT3; TGFB1I1; SLIT1
    calcium ion binding ICN; ANXA11; PRRG4; DSG1A; CASQ1; S100B; CALB2; RHOT2; GUCA1A; EGFL8
    chemorepellent activity Sema3f; SEMA6DL; SEMA6C; UBE4A; SEMA3E; SEMA4D; SEMA3G; SEMA3B; SEMA3FA; NRG3
    heparan sulfate proteoglycan binding GPC4; Itgam&Itgb2; GPC6; GPC5; GPC1B; GPC1; AZU1; ITGAM; SLIT2; GPC6A
    heparin binding SMOC2; SERPINA5; MPO; CCL23; ADAMTS8; PRELP; SLIT1A; CXCL11; NRP1A; PCOLCE
    identical protein binding RALYL; MRFAP1L1; CLDN11; SH3GLB1; DYNLT1A; SMAD6; PLEKHH2; TNK2; MRI1; RBM10
    laminin-1 binding LACRT; DAG1; NTN4; Shh; NID1; SLIT2; UBE4A
    protein binding CTNNA1; FANCA; PRKCZ; MED19; Raet1c; MAP3K7; KLRC4-KLRK1; NACC2; TSC22D4; ADAMTS4
    protein homodimerization activity XDH; FZD1; BAX; AADAT; RAB11FIP3; CACYBP; UBE4A; FBXO4; CRYBB2; CECR1
    proteoglycan binding COL5A1; SLIT2; CTSB; FCN2; THBS1; UBE4A; NID1; CECR1; CECR1A; CTSS

    UBE4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE4A here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE4A.

    MAVS; PTP4A3; UBE2D1; UBE2D3; UBE2D2; UBE2D4; CBX7

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