| Description : |
This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
123.3 kDa |
| AA Sequence : |
MTDQENNNNISSNPFAALFGSLADA KQFAAIQKEQLKQQSDELPASPDDS DNSVSESLDEFDYSVAEISRSFRSQ QEICEQLNINHMIQRIFLITLDNSD PSLKSGNGIPSRCVYLEEMAVELED QDWLDMSNVEQALFARLLLQDPGNH LINMTSSTTLNLSADRDAGERHIFC YLYSCFQRAKEEITKVPENLLPFAV QCRNLTVSNTRTVLLTPEIYVDQNI HEQLVDLMLEAIQGAREYMNKIYFE DVTEFLEEVIEALILDEEVRTFPEV MIPVFDILLGRIKDLELCQILLYAY LDILLYFTRQKDMAKVFVEYIQPKD PTNGQMYQKTLLGVILSISCLLKTP GVVENHGYFLNPSRSSPQEIKVQEA NIHQFMAQFHEKIYQMLKNLLQLSP ETKHCILSWLGNCLHANAGRTKIWA NQMPEIFFQMYASDAFFLNLGAALL KLCQPFCKPRSSRLLTFNPTYCALK ELNDEERKIKNVHMRGLDKETCLIP AVQEPKFPQNYNLVTENLALTEYTL YLGFHRLHDQMVKINQNLHRLQVAW RDAQQSSSPAADNLREQFERLMTIY LSTKTAMTEPQMLQNCLNLQVSMAV LLVQLAIGNEGSQPIELTFPLPDGY SSLAYVPEFFADNLGDFLIFLRRFA DDILETSADSLEHVLHFITIFTGSI ERMKNPHLRAKLAEVLEAVMPHLDQ TPNPLVSSVFHRKRVFCNFQYAPQL AEALIKVFVDIEFTGDPHQFEQKFN YRRPMYPILRYMWGTDTYRESIKDL ADYASKNLEAMNPPLFLRFLNLLMN DAIFLLDEAIQYLSKIKIQQIEKDR GEWDSLTPEARREKEAGLQMFGQLA RFHNIMSNETIGTLAFLTSEIKSLF VHPFLAERIISMLNYFLQHLVGPKM GALKVKDFSEFDFKPQQLVSDICTI YLNLGDEENFCATVPKDGRSYSPTL FAQTVRVLKKINKPGNMIMAFSNLA ERIKSLADLQQQEEETYADACDEFL DPIMSTLMCDPVVLPSSRVTVDRST IARHLLSDQTDPFNRSPLTMDQIRP NTELKEKIQRWLAERKQQKEQLETR TRPLEQKLISEEDLAANDILDYKDD DDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
