ugt1a3
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  • Official Full Name
  • UDP glucuronosyltransferase 1 family, polypeptide A3
  • Background
  • This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzo alpha-pyrene.
  • Synonyms
  • UGT1A3; UDP glucuronosyltransferase 1 family, polypeptide A3; UDP glycosyltransferase 1 family, polypeptide A3; UDP-glucuronosyltransferase 1-3; UGT1C; EC 2.4.1.17; GNT 1; GNT1; UDP glucuronosyltransferase 1 3; UDP glucuronosyltransferase 1 family polypeptide A3; UDP glucuronosyltransferase 1A3; UDP glucuronosyltransferase; UDP glycosyltransferase 1 family polypeptide A3; UDPGT; UGT 1; UGT 1C; UGT1; UGT1 03; UGT1*3; UGT1.3; OTTHUMP00000065193; UDP-glucuronosyltransferase 1-C; UDP-glucuronosyltransferase 1A3; UGT-1C; UGT1-03; UDPGT 1-3
Cat.#:UGT1A3-512HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human UGT1A3 Protein, MYC/DDK-tagged
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Cat.#:UGT1A3-207HTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human UGT1A3
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Involved Pathway

UGT1A3 involved in several pathways and played different roles in them. We selected most pathways UGT1A3 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Pentose and glucuronate interconversions
UGT2A2; UGT1A9; AKR1A1A; UGT5G1; UGT1A3; UGP2A; GKUP; ALDH1B1; DHDH; UGT2B7
Ascorbate and aldarate metabolism
UGT1A6B; ALDH3A2A; ALDH2; UGT1A2; UGDH; UGT1A9; ALDH9A1B; UGT1A6A; UGT5G1; UGT1A6
Steroid hormone biosynthesis
HSD17B6; HSD17B12B; CYP2C54; AKR1C3; HSD3B4; HSD11B2; UGT2A1; CYP2D26; CYP2C70; COMTB
Starch and sucrose metabolism
G6PC2; SI; GAA; GBA3; UGT1A7; AMY2B; UGT1A3; UGT1AB; G6PCA.2; AMY2A
Retinol metabolism
DHRS4L2; UGT1A3; RETSATL; RDH8A; CYP2C54; CYP2A4; UGT1A7C; SDR16C5A; UGT2B15; UGT5G1
Porphyrin and chlorophyll metabolism
UGT2A1; HCCS; HMOX2A; UGT1A6B; UGT5G1; UGT1A6; HMBSA; EPRS; CPOX; UGT1A4
Metabolism of xenobiotics by cytochrome P
UGT2A1; AKR7A5; UGT1A6A; GSTT2B; UGT2B15; EPHX1; GSTAL; AKR7A2; ADH1; ALDH1A3
Drug metabolism - cytochrome P
GSTA; ALDH1A3; AOX3L1; UGT1AB; MGST1; MGST1.1; GSTA5; FMO5; FMO1; AOX1
Drug metabolism - other enzymes
GUSB; UGT1A4; Ces2c; UGT1A9; UCKL1; Ces2e; UGT1A1; UGT1A7; UGT2A3; TK1
Metabolic pathways
MPST; ST6GALNAC4; EPHX2; PLCD3; MGAT5; RRM1; POLR2K; AGXTB; HSD3B2; PCYT1A
Chemical carcinogenesis
MGST2; GSTA1; ADH1B; CYP2C9; CYP3A41A; CYP3A5; GSTM2; CYP2C37; GSTK1; ADH6

Protein Function

UGT1A3 has several biochemical functions, for example, enzyme binding, glucuronosyltransferase activity, NOT glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A3 itself. We selected most functions UGT1A3 had, and list some proteins which have the same functions with UGT1A3. You can find most of the proteins on our site.
Function
Related Protein
Function enzyme binding
Related Protein CYP2A4; ERN1; CTNNBL1; PLCB1; UGT1A1; BCHE; PDE4D; IQCB1; PAWR; TMBIM6
Function glucuronosyltransferase activity
Related Protein CSGALNACT1; UGT1AB; UGT5F1; UGT1B3; UGT2B3; UGT5A1; UGT5A4; UGT5C2; UGT1A9; UGT2A5
Function NOT glucuronosyltransferase activity
Related Protein UGT1A3; UGT1A7; UGT1A4; UGT1A1; UGT1A9; UGT1A6
Function protein heterodimerization activity
Related Protein TYRO3; HIST2H2AC; DR1; CHRNB2; PDGFB; HIST1H3D; KATNB1; SUPT5H; TIRAP; NFYBB
Function protein homodimerization activity
Related Protein ANXA9; VPS4B; PON3; MAP3K13; HSF2; OLIG2; LGALS6; JAM3; SLC14A2; MVD
Function retinoic acid binding
Related Protein LRAT; CRABP1A; UGT1A9; PTGDSB; LCN12; CRABP2A; CRABP1B; CYP26B1; CYP26A1; UGT1A3

UGT1A3 Related Articles

Lee, SJ; Park, JB; et al. In vitro selective inhibition of human UDP-glucuronosyltransferase (UGT) 1A4 by finasteride, and prediction of in vivo drug-drug interactions. TOXICOLOGY LETTERS 232:458-465(2015).
Tian, XG; Liang, SC; et al. Regioselective Glucuronidation of Andrographolide and Its Major Derivatives: Metabolite Identification, Isozyme Contribution, and Species Differences. AAPS JOURNAL 17:156-166(2015).