ugt2b15
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  • Official Full Name
  • UDP glucuronosyltransferase 2 family, polypeptide B15
  • Background
  • This gene encodes a member of the UDP-glycosyltransferase (UDPGT) family. The UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein displays activity towards several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens.
  • Synonyms
  • UGT2B15; UDP glucuronosyltransferase 2 family, polypeptide B15; UDP glycosyltransferase 2 family, polypeptide B15; UDP-glucuronosyltransferase 2B15; UGT2B8; EC 2.4.1.17; HLUG4; UDP glucuronosyltransferase 2 family polypeptide B15; UDP glucuronosyltransferase 2 family, member B15; UDP glucuronosyltransferase 2 family, member B8; UDP glucuronosyltransferase 2B15; UDP glucuronosyltransferase UGT2B15; UDP glucuronyltransferase family 2 beta 15; UDP glycosyltransferase 2 family, member B15; UDP glycosyltransferase 2B15; UDPGT 2B15; UDPGT2B15; UDPGTh 3; UDPGTH3; Uridine diphosphate glucuronosyltransferase 2 family, member B8; Uridine diphosphate glycosyltransferase 2 family, member B15; UDPGTh-3; UDP-glucuronosyltransferase 2B8; UDP-glucuronosyltransferase UGT2B15; UDP-glucuronyltransferase, family 2, beta-15; UDPGT 2B8
Cat.#:UGT2B15-1880HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UGT2B15 cell lysate
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Involved Pathway

UGT2B15 involved in several pathways and played different roles in them. We selected most pathways UGT2B15 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT2B15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Pentose and glucuronate interconversions
DCXR; UGT2A1; AKR1B1L; UGP2A; ALDH2.1; XYLB; UGT1A7; UGT1AB; UGT2A3; UGT1A6A
Ascorbate and aldarate metabolism
UGT1A1; MIOX; ALDH3A2A; UGT2B15; UGT1A6; GKUP; ALDH7A1; UGT2A3; UGT2B7; UGT5G1
Steroid hormone biosynthesis
UGT1AB; CYP1A; CYP3A41A; SRD5A2B; CYP3A65; AKR1C3; CYP3A7; SRD5A2A; HSD17B8; UGT1A6A
Starch and sucrose metabolism
G6PC2; UGT2A2; AGL; PGM2; G6PCA.2; UGT1A6B; UGP2A; HK2; ENPP1; GPI1
Retinol metabolism
CYP2C45; CYP2B19; RETSAT; BCO1; UGT2B15; CYP2C38; UGT1A9; UGT1A1; CYP2C54; CYP3A7-CYP3AP1
Porphyrin and chlorophyll metabolism
HMBSB; ALAD; PPOX; BLVRA; BLVRB; EPRS; UGT1A7C; CP; COX15; CPOX
Metabolism of xenobiotics by cytochrome P
UGT2B15; ALDH3A1; GSTM5; GSTM6; UGT1A2; GSTM1; ALDH3B1; GSTM7; UGT1A6; UGT2A1
Drug metabolism - cytochrome P
UGT1A4; FMO2; ADH1; ALDH3B2; UGT1A7; UGT2A3; GSTA5; GSTA1; FMO5; GSTO1
Drug metabolism - other enzymes
Ces2c; DPYS; CYP2A6; NAT; UGT1A7; UCKL1; CDA; TPMT.1; CES1; ITPA
Metabolic pathways
ADKB; SDHDB; PDHX; RRM1; COX7C; PNPO; CBR3; PLA2G4AA; AGXT; AHCY
Chemical carcinogenesis
UGT2A1; UGT1A7C; CYP2C18; NAT1; CYP3A41B; GSTP1; UGT1A3; ALDH3B1; UGT2B15; CYP2C9

Protein Function

UGT2B15 has several biochemical functions, for example, glucuronosyltransferase activity, NOT retinoic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT2B15 itself. We selected most functions UGT2B15 had, and list some proteins which have the same functions with UGT2B15. You can find most of the proteins on our site.
Function
Related Protein
Function glucuronosyltransferase activity
Related Protein EXT1; UGT2A5; UGT2A6; UGT2B15; UGT1B5; UGT8; UGT5A3; UGT1B4; UGT5A4; UGT8A
Function NOT retinoic acid binding
Related Protein UGT1A6; UGT2B7; UGT2B15; UGT1A4

UGT2B15 Related Articles

Izukawa, T; Nakajima, M; et al. Quantitative Analysis of UDP-Glucuronosyltransferase (UGT) 1A and UGT2B Expression Levels in Human Livers. DRUG METABOLISM AND DISPOSITION 37:1759-1768(2009).
Chouinard, S; Yueh, MF; et al. Inactivation by UDP-glucuronosyltransferase enzymes: The end of androgen signaling. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 109:247-253(2008).