WNK2

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WNK2

Official Full Name WNK lysine deficient protein kinase 2
Background The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Synonyms WNK2; WNK lysine deficient protein kinase 2; PRKWNK2; NY-CO-43; SDCCAG43; P/OKcl.13; serine/threonine-protein kinase WNK2; antigen NY-CO-43; protein kinase with no lysine 2; protein kinase lysine-deficient 2; protein kinase, lysine deficient 2; serologically defined colon cancer antigen 43; mitogen-activated protein kinase kinase kinase;
    • Type:
    • Species :
    • Mouse
    • Source :
    • Mammalian Cell
    • Tag :
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse WNK2-18561M Recombinant Mouse WNK2 Protein Mammalian Cell His

    WNK2 involved in several pathways and played different roles in them. We selected most pathways WNK2 participated on our site, such as Ion channel transport, Stimuli-sensing channels, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ion channel transport ANO10; MCOLN2; ATP10A; CLCA1; ANO6; CLCN2; ATP13A; ATP2C2; TTYH3; CLCN1A
    Stimuli-sensing channels OSTM1; CLCNK; TTYH3B; SLC17A3; ANO10; CLCN4; TPCN1; TRPA1A; TRPC4A; BEST4
    Transmembrane transport of small molecules FKBP1B; MCOLN2; SLC2A13; FXYD6-FXYD2; MATE4; MIPB; SLC1A2B; TRPV3; SLC39A1; SLC39A14

    WNK2 has several biochemical functions, for example, ATP binding, kinase activity, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by WNK2 itself. We selected most functions WNK2 had, and list some proteins which have the same functions with WNK2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding RARS2; PANK1B; SRPK2; HUNK; ALK; SPO11; SGK196; RTCD1; MCM8; UBE2D1
    kinase activity ZNF143B; LMTK3; PRKACAB; TGFBR1B; LRGUK; NEK4; CDK12; ADKB; CDC7; CKBB
    molecular_function LRIT1; BTNL3; CRP4; KIAA0247; GUCD1; HIST1H2AC; HID1B; EML4; CACFD1; LEMD2
    nucleotide binding ATP2B3B; BMPR2B; GC3; SETX; GRSF1; EPHA4A; MCM3L; PIF1; TUBA7L; DNAJC17
    protein kinase activity MAP3K12; NEK10; TLK1A; PRKG1A; STK30; LMTK3; IRAK4; RPS6KB2; MAP4K5; CAMK2D2
    protein serine/threonine kinase activity STK39; PLK1; PRKY; PDIK1L; EIF2AK4; MAP3K11; TRIOA; MYO3A; PAK2B; CDK15
    transferase activity SMYD2A; BMPR2A; DGKAA; GRK1B; UGT5B3; RPS6KA3A; MAPK14A; PIK3R3B; GOT2A; MAPK8A

    WNK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WNK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of WNK2.

    Lai, JG; Tsai, SM; et al. Zebrafish WNK Lysine Deficient Protein Kinase 1 (wnk1) Affects Angiogenesis Associated with VEGF Signaling. PLOS ONE 9:-(2014).
    de los Heros, P; Alessi, DR; et al. The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters. BIOCHEMICAL JOURNAL 458:559-573(2014).

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